The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate.
The fight-or-flight response (also called hyperarousal, or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
Tamsulosin, sold under the trade name Alna ® / Flomax ®, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis, help with the passage of kidney stones, and for urinary retention along with other measures.
WB-4101 is a compound which acts as an antagonist at the α1B-adrenergic receptor.
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.