Faster access than browser!
76 relations: A53T Mutation, Alpha helix, Alternative splicing, Alzheimer's disease, Amino acid, Amphiphile, Amyloid, Amyloid beta, Antibody, Antioxidant, Apolipoprotein, Autoxidation, Beta sheet, Biomolecular structure, C-terminus, Cell membrane, Cerebellum, Chaperone (protein), Chemical synapse, Consensus sequence, Contursi Terme, Copper, Cryogenic electron microscopy, Cuminaldehyde, Cytosol, Dementia with Lewy bodies, Deuterated drug, Dopamine transporter, Epstein–Barr virus, Gene, Golgi apparatus, Hippocampus, Immunostaining, Intrinsically disordered proteins, Ion-mobility spectrometry–mass spectrometry, Iron, Lewy body, Microphthalmia-associated transcription factor, Molecular mass, Monounsaturated fat, Multiple system atrophy, N-terminus, Neocortex, Nervous tissue, Optical tweezers, Parkin (ligase), Parkinson's disease, Phospholipase D1, Phospholipid, Point mutation, ..., Polyunsaturated fatty acid, Prion, Proline, Protein, Protein aggregation, Protein dimer, Protein–protein interaction, Proteolysis, Regulation of gene expression, Saccharomyces cerevisiae, SNARE (protein), SNCAIP, Substantia nigra, Synaptobrevin, Synuclein, Synucleinopathy, Tau protein, Tauopathy, Tetramer, Thalamus, Torpedo (genus), Transition metal, Tubulin, Ubiquitin, Unified atomic mass unit, Vesicle (biology and chemistry). Expand index (26 more) »
A53T Mutation
A53T Mutation is a 140-amino acid protein found in pre-synaptic terminals of neurons in the brain, and is a point mutation of the Alpha-synuclein protein.
New!!: Alpha-synuclein and A53T Mutation · See more »
Alpha helix
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
New!!: Alpha-synuclein and Alpha helix · See more »
Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
New!!: Alpha-synuclein and Alternative splicing · See more »
Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
New!!: Alpha-synuclein and Alzheimer's disease · See more »
Amino acid
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
New!!: Alpha-synuclein and Amino acid · See more »
Amphiphile
An amphiphile (from the Greek αμφις, amphis: both and φιλíα, philia: love, friendship) is a chemical compound possessing both hydrophilic (water-loving, polar) and lipophilic (fat-loving) properties.
New!!: Alpha-synuclein and Amphiphile · See more »
Amyloid
Amyloids are aggregates of proteins that become folded into a shape that allows many copies of that protein to stick together forming fibrils.
New!!: Alpha-synuclein and Amyloid · See more »
Amyloid beta
Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients.
New!!: Alpha-synuclein and Amyloid beta · See more »
Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
New!!: Alpha-synuclein and Antibody · See more »
Antioxidant
Antioxidants are molecules that inhibit the oxidation of other molecules.
New!!: Alpha-synuclein and Antioxidant · See more »
Apolipoprotein
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins.
New!!: Alpha-synuclein and Apolipoprotein · See more »
Autoxidation
Autoxidation is any oxidation that occurs in open air or in presence of oxygen (and sometimes UV radiation) and forms peroxides and hydroperoxides.
New!!: Alpha-synuclein and Autoxidation · See more »
Beta sheet
The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.
New!!: Alpha-synuclein and Beta sheet · See more »
Biomolecular structure
Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.
New!!: Alpha-synuclein and Biomolecular structure · See more »
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
New!!: Alpha-synuclein and C-terminus · See more »
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
New!!: Alpha-synuclein and Cell membrane · See more »
Cerebellum
The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates.
New!!: Alpha-synuclein and Cerebellum · See more »
Chaperone (protein)
In molecular biology, molecular chaperones are proteins that assist the covalent folding or unfolding and the assembly or disassembly of other macromolecular structures.
New!!: Alpha-synuclein and Chaperone (protein) · See more »
Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
New!!: Alpha-synuclein and Chemical synapse · See more »
Consensus sequence
In molecular biology and bioinformatics, the consensus sequence (or canonical sequence) is the calculated order of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment.
New!!: Alpha-synuclein and Consensus sequence · See more »
Contursi Terme
Contursi Terme (Contursano: Cundurs) is a village and comune in the province of Salerno in the Campania region of south-western Italy.
New!!: Alpha-synuclein and Contursi Terme · See more »
Copper
Copper is a chemical element with symbol Cu (from cuprum) and atomic number 29.
New!!: Alpha-synuclein and Copper · See more »
Cryogenic electron microscopy
Electron cryomicroscopy (CryoEM) is an electron microscopy (EM) technique where the sample is cooled to cryogenic temperatures.
New!!: Alpha-synuclein and Cryogenic electron microscopy · See more »
Cuminaldehyde
Cuminaldehyde, or 4-isopropylbenzaldehyde, is a natural organic compound with the molecular formula C10H12O.
New!!: Alpha-synuclein and Cuminaldehyde · See more »
Cytosol
The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.
New!!: Alpha-synuclein and Cytosol · See more »
Dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a type of dementia accompanied by changes in behavior, cognition and movement.
New!!: Alpha-synuclein and Dementia with Lewy bodies · See more »
Deuterated drug
Deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms contained in the drug molecule have been replaced by its heavier stable isotope deuterium.
New!!: Alpha-synuclein and Deuterated drug · See more »
Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
New!!: Alpha-synuclein and Dopamine transporter · See more »
Epstein–Barr virus
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known human herpesvirus types in the herpes family, and is one of the most common viruses in humans.
New!!: Alpha-synuclein and Epstein–Barr virus · See more »
Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
New!!: Alpha-synuclein and Gene · See more »
Golgi apparatus
The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells.
New!!: Alpha-synuclein and Golgi apparatus · See more »
Hippocampus
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
New!!: Alpha-synuclein and Hippocampus · See more »
Immunostaining
In biochemistry, immunostaining is any use of an antibody-based method to detect a specific protein in a sample.
New!!: Alpha-synuclein and Immunostaining · See more »
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.
New!!: Alpha-synuclein and Intrinsically disordered proteins · See more »
Ion-mobility spectrometry–mass spectrometry
Ion-mobility spectrometry–mass spectrometry (IMS-MS), also known as ion-mobility separation–mass spectrometry, is an analytical chemistry method that separates gas phase ions on a millisecond timescale using ion-mobility spectrometry and uses mass spectrometry on a microsecond timescale to identify components in a sample.
New!!: Alpha-synuclein and Ion-mobility spectrometry–mass spectrometry · See more »
Iron
Iron is a chemical element with symbol Fe (from ferrum) and atomic number 26.
New!!: Alpha-synuclein and Iron · See more »
Lewy body
Lewy bodies are abnormal aggregates of protein that develop inside nerve cells, contributing to Parkinson's disease (PD), the Lewy body dementias (Parkinson's disease dementia and dementia with Lewy bodies), and some other disorders.
New!!: Alpha-synuclein and Lewy body · See more »
Microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene.
New!!: Alpha-synuclein and Microphthalmia-associated transcription factor · See more »
Molecular mass
Relative Molecular mass or molecular weight is the mass of a molecule.
New!!: Alpha-synuclein and Molecular mass · See more »
Monounsaturated fat
In biochemistry and nutrition, monounsaturated fatty acids (abbreviated MUFAs, or more plainly monounsaturated fats) are fatty acids that have one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded.
New!!: Alpha-synuclein and Monounsaturated fat · See more »
Multiple system atrophy
Multiple system atrophy (MSA), also known as Shy–Drager syndrome, is a rare neurodegenerative disorder characterized by tremors, slow movement, muscle rigidity, and postural instability (collectively known as parkinsonism) due to dysfunction of the autonomic nervous system, and ataxia.
New!!: Alpha-synuclein and Multiple system atrophy · See more »
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
New!!: Alpha-synuclein and N-terminus · See more »
Neocortex
The neocortex, also called the neopallium and isocortex, is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language.
New!!: Alpha-synuclein and Neocortex · See more »
Nervous tissue
Nervous tissue or nerve tissue is the main tissue component of the two parts of the nervous system; the brain and spinal cord of the central nervous system (CNS), and the branching peripheral nerves of the peripheral nervous system (PNS), which regulates and controls bodily functions and activity.
New!!: Alpha-synuclein and Nervous tissue · See more »
Optical tweezers
Optical tweezers (originally called "single-beam gradient force trap") are scientific instruments that use a highly focused laser beam to provide an attractive or repulsive force (typically on the order of piconewtons), depending on the relative refractive index between particle and surrounding medium, to physically hold and move microscopic objects similar to tweezers.
New!!: Alpha-synuclein and Optical tweezers · See more »
Parkin (ligase)
Parkin is a 465-residue E3 ubiquitin ligase that plays a critical role in ubiquitination- the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes.
New!!: Alpha-synuclein and Parkin (ligase) · See more »
Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
New!!: Alpha-synuclein and Parkinson's disease · See more »
Phospholipase D1
Phospholipase D1 is an enzyme that in humans is encoded by the PLD1 gene.
New!!: Alpha-synuclein and Phospholipase D1 · See more »
Phospholipid
Phospholipids are a class of lipids that are a major component of all cell membranes.
New!!: Alpha-synuclein and Phospholipid · See more »
Point mutation
A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA.
New!!: Alpha-synuclein and Point mutation · See more »
Polyunsaturated fatty acid
Polyunsaturated fatty acids (PUFAs) are fatty acids that contain more than one double bond in their backbone.
New!!: Alpha-synuclein and Polyunsaturated fatty acid · See more »
Prion
Prions are misfolded proteins that are associated with several fatal neurodegenerative diseases in animals and humans.
New!!: Alpha-synuclein and Prion · See more »
Proline
Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.
New!!: Alpha-synuclein and Proline · See more »
Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
New!!: Alpha-synuclein and Protein · See more »
Protein aggregation
Protein aggregation is a biological phenomenon in which mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly.
New!!: Alpha-synuclein and Protein aggregation · See more »
Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
New!!: Alpha-synuclein and Protein dimer · See more »
Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
New!!: Alpha-synuclein and Protein–protein interaction · See more »
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
New!!: Alpha-synuclein and Proteolysis · See more »
Regulation of gene expression
Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA), and is informally termed gene regulation.
New!!: Alpha-synuclein and Regulation of gene expression · See more »
Saccharomyces cerevisiae
Saccharomyces cerevisiae is a species of yeast.
New!!: Alpha-synuclein and Saccharomyces cerevisiae · See more »
SNARE (protein)
SNARE proteins (an acronym derived from "SNAP (Soluble NSF(N-ethylmaleimide-sensitive factor) Attachment Protein) REceptor)" are a large protein complex consisting of at least 24 members in yeasts and more than 60 members in mammalian cells.
New!!: Alpha-synuclein and SNARE (protein) · See more »
SNCAIP
Synphilin-1 is a protein that in humans is encoded by the SNCAIP gene.
New!!: Alpha-synuclein and SNCAIP · See more »
Substantia nigra
The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.
New!!: Alpha-synuclein and Substantia nigra · See more »
Synaptobrevin
Synaptobrevins (synaptobrevin isotypes 1-2) are small integral membrane proteins of secretory vesicles with molecular weight of 18 kilodalton (kDa) that are part of the vesicle-associated membrane protein (VAMP) family.
New!!: Alpha-synuclein and Synaptobrevin · See more »
Synuclein
Synucleins are a family of soluble proteins common to vertebrates, primarily expressed in neural tissue and in certain tumors.
New!!: Alpha-synuclein and Synuclein · See more »
Synucleinopathy
Synucleinopathies (also called α-Synucleinopathies) are neurodegenerative diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells.
New!!: Alpha-synuclein and Synucleinopathy · See more »
Tau protein
Tau proteins (or τ proteins, after the Greek letter with that name) are proteins that stabilize microtubules.
New!!: Alpha-synuclein and Tau protein · See more »
Tauopathy
Tauopathy belongs to a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in neurofibrillary or gliofibrillary tangles in the human brain.
New!!: Alpha-synuclein and Tauopathy · See more »
Tetramer
A tetramer (tetra-, "four" + -mer, "parts") is an oligomer formed from four monomers or subunits.
New!!: Alpha-synuclein and Tetramer · See more »
Thalamus
The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.
New!!: Alpha-synuclein and Thalamus · See more »
Torpedo (genus)
Torpedo is a genus of rays, commonly known as electric rays, torpedo rays, or torpedoes.
New!!: Alpha-synuclein and Torpedo (genus) · See more »
Transition metal
In chemistry, the term transition metal (or transition element) has three possible meanings.
New!!: Alpha-synuclein and Transition metal · See more »
Tubulin
Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.
New!!: Alpha-synuclein and Tubulin · See more »
Ubiquitin
Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.
New!!: Alpha-synuclein and Ubiquitin · See more »
Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
New!!: Alpha-synuclein and Unified atomic mass unit · See more »
Vesicle (biology and chemistry)
In cell biology, a vesicle is a small structure within a cell, or extracellular, consisting of fluid enclosed by a lipid bilayer.
New!!: Alpha-synuclein and Vesicle (biology and chemistry) · See more »
Redirects here:
Alpha synuclein, SNCA (gene), Α-Synuclein, Α-synuclein.
References
[1] https://en.wikipedia.org/wiki/Alpha-synuclein
