77 relations: Acne, Adrenergic receptor, Alkaline phosphatase, Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor, Anaphylaxis, Anxiety, Artery, Athens, Atypical antidepressant, Bilirubin, Binding selectivity, Biological half-life, Breastfeeding, Bulimia nervosa, Chorea, Cmax (pharmacology), Cytolysis, Dextroamphetamine, Dijon, Dopamine, Dopamine receptor, Dopamine receptor D1, Dopamine receptor D2, Dopamine releasing agent, Dopamine reuptake inhibitor, Europe, Food and Drug Administration, General anaesthesia, Hepatitis, Hepatotoxicity, Histamine H1 receptor, Histamine receptor, Hypersensitivity, Hypotension, IC50, Insomnia, Irritability, Isotretinoin, Kidney, Laboratoires Servier, Liver, Major depressive disorder, Medication, Medifoxamine, Metabolite, Monoamine oxidase inhibitor, Monoamine releasing agent, Monoamine transporter, Muscarinic acetylcholine receptor, ..., Nomifensine, Norepinephrine, Norepinephrine reuptake inhibitor, Olympic Games, Opiate, Oral administration, Palpitations, Pancreatitis, Pharmacovigilance, Potency (pharmacology), Pregnancy, Reflex syncope, Reuptake, Reuptake inhibitor, Revue de Médecine Interne, Schizophrenia, Stimulant, Substance dependence, Suicide crisis, Teratology, Thorax, Tianeptine, Transaminase, Tricyclic antidepressant, 5-HT receptor, 5-HT1A receptor, 5-HT2A receptor. Expand index (27 more) » « Shrink index
Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.
The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).
Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) or basic phosphatase is a homodimeric protein enzyme of 86 kilodaltons.
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.
An artery (plural arteries) is a blood vessel that takes blood away from the heart to all parts of the body (tissues, lungs, etc).
Athens (Αθήνα, Athína; Ἀθῆναι, Athênai) is the capital and largest city of Greece.
An atypical antidepressant is a type of antidepressant medication which acts in an atypical manner relative to most other antidepressants.
Bilirubin is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
Breastfeeding, also known as nursing, is the feeding of babies and young children with milk from a woman's breast.
Bulimia nervosa, also known as simply bulimia, is an eating disorder characterized by binge eating followed by purging.
Chorea (or choreia, occasionally) is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias.
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
Cytolysis, or osmotic lysis, occurs when a cell bursts due to an osmotic imbalance that has caused excess water to diffuse into the cell.
Dextroamphetamine is a potent central nervous system (CNS) stimulant and amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
Dijon is a city in eastern:France, capital of the Côte-d'Or département and of the Bourgogne-Franche-Comté region.
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain.
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT).
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
General anaesthesia or general anesthesia (see spelling differences) is a medically induced coma with loss of protective reflexes, resulting from the administration of one or more general anaesthetic agents.
Hepatitis is inflammation of the liver tissue.
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.
Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity.
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
Irritability is the excitatory ability that living organisms have to respond to changes in their environment.
Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane or Roaccutane), is a medication primarily used to treat severe acne.
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
Servier Laboratories (French: Laboratoires Servier, often abbreviated to Servier) is a privately owned French pharmaceutical company that specialises in medication for cardiological and rheumatological conditions, as well as for diabetes and clinical depression.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco.
A metabolite is the intermediate end product of metabolism.
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the release of a monoamine neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.
Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters.
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
A norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).
The modern Olympic Games or Olympics (Jeux olympiques) are leading international sporting events featuring summer and winter sports competitions in which thousands of athletes from around the world participate in a variety of competitions.
Opiate is a term classically used in pharmacology to mean a drug derived from opium.
Palpitations are the perceived abnormality of the heartbeat characterized by awareness of cardiac muscle contractions in the chest: hard, fast and/or irregular beats.
Pancreatitis is inflammation of the pancreas.
Pharmacovigilance (PV or PhV), also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products.
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.
Reflex syncope is a brief loss of consciousness due to a neurologically induced drop in blood pressure.
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.
The Revue de Médecine Interne is a French medical journal that covers research in internal medicine.
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.
Substance dependence also known as drug dependence is an adaptive state that develops from repeated drug administration, and which results in withdrawal upon cessation of drug use.
A suicide crisis, suicidal crisis, attempted suicide or potential suicide, is a situation in which a person is attempting to kill themselves or is seriously contemplating or planning to do so.
Teratology is the study of abnormalities of physiological development.
The thorax or chest (from the Greek θώραξ thorax "breastplate, cuirass, corslet" via thorax) is a part of the anatomy of humans and various other animals located between the neck and the abdomen.
Tianeptine, sold under the brand names Stablon and Coaxil among others, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome.
Transaminases or aminotransferases are enzymes that catalyze a transamination reaction between an amino acid and an α-keto acid.
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).