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Aminolevulinic acid synthase

Index Aminolevulinic acid synthase

Aminolevulinic acid synthase (ALA synthase, ALAS, or delta-aminolevulinic acid synthase) is an enzyme that catalyzes the synthesis of D-aminolevulinic acid (ALA) the first common precursor in the biosynthesis of all tetrapyrroles such as hemes, cobalamins and chlorophylls. [1]

16 relations: ALAS1, ALAS2, Amine, Aminolevulinic acid, Carboxylic acid, Coenzyme A, Glucose, Glycine, Hemin, Iron, Mitochondrion, Pyridinium, Pyridoxal phosphate, Sideroblastic anemia, Succinyl-CoA, Tetrapyrrole.

ALAS1

Delta-aminolevulinate synthase 1 also known as ALAS1 is a protein that in humans is encoded by the ALAS1 gene.

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ALAS2

Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein that in humans is encoded by the ALAS2 gene.

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Amine

In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.

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Aminolevulinic acid

δ-Aminolevulinic acid (also dALA, δ-ALA, 5ALA or 5-aminolevulinic acid), an endogenous non-protein amino acid, is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll in plants.

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Carboxylic acid

A carboxylic acid is an organic compound that contains a carboxyl group (C(.

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Coenzyme A

Coenzyme A (CoA,SCoA,CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle.

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Glucose

Glucose is a simple sugar with the molecular formula C6H12O6.

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Glycine

Glycine (symbol Gly or G) is the amino acid that has a single hydrogen atom as its side chain.

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Hemin

Hemin (haemin; ferric chloride heme) is an iron-containing porphyrin with chlorine that can be formed from a haem group, such as haem b found in the haemoglobin of human blood.

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Iron

Iron is a chemical element with symbol Fe (from ferrum) and atomic number 26.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Pyridinium

Pyridinium refers to the cation +. It is the conjugate acid of pyridine.

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Pyridoxal phosphate

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.

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Sideroblastic anemia

Sideroblastic anemia or sideroachrestic anemia is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes).

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Succinyl-CoA

Succinyl-Coenzyme A, abbreviated as Succinyl-CoA or SucCoA, is a combination of succinic acid and coenzyme A.

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Tetrapyrrole

Tetrapyrroles are a class of chemical compounds that contain four pyrrole or pyrrole-like rings.

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Redirects here:

5-aminolevulinate synthase, ALA synthase, Ala synthase, Amino lavulinic acid synthase, EC 2.3.1.37, Succinyl-CoA:glycine C-succinyltransferase (decarboxylating).

References

[1] https://en.wikipedia.org/wiki/Aminolevulinic_acid_synthase

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