Androstenediol

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). ^[1]

44 relations: Acute radiation syndrome, Adrenal cortex, Anabolic steroid, Androgen, Androstane, Androstenedione, Armed Forces Radiobiology Research Institute, Biological activity, Biosynthesis, Chemical synthesis, Clinical trial, Dehydroepiandrosterone, Derivative (chemistry), Endogeny (biology), Estradiol, Estrane, Estrogen, Estrogen receptor alpha, Estrogen receptor beta, Ethinylandrostenediol, Immune system, In vivo, Ionizing radiation, Ligand (biochemistry), List of androgen esters, Metabolite, Methandriol, Natural product, Oral administration, Placebo, Platelet, Rat, Reaction intermediate, Rhesus macaque, Steroid, Steroid hormone, Structural analog, Testosterone, United States Department of Health and Human Services, White blood cell, 17α-Alkylated anabolic steroid, 19-Nor-5-androstenediol, 3β-Androstanediol, 4-Androstenediol.
Pregnane X receptor agonists
Selective ERβ agonists

Acute radiation syndrome

Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation in a short period of time.

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Adrenal cortex

The adrenal cortex is the outer region and also the largest part of the adrenal gland.

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Anabolic steroid

Anabolic steroids, also known as anabolic-androgenic steroids (AAS), are a class of drugs that are structurally related to testosterone, the main male sex hormone, and produce effects by binding to the androgen receptor (AR). Androstenediol and anabolic steroid are anabolic–androgenic steroids.

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Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. Androstenediol and androgen are anabolic–androgenic steroids.

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Androstane

Androstane is a C19 steroidal hydrocarbon with a gonane core. Androstenediol and Androstane are anabolic–androgenic steroids and Androstanes.

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Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA). Androstenediol and Androstenedione are anabolic–androgenic steroids, Androstanes, estrogens and Pregnane X receptor agonists.

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Armed Forces Radiobiology Research Institute

The Armed Forces Radiobiology Research Institute (AFRRI) is an American triservice research laboratory in Bethesda, Maryland chartered by Congress in 1960 and formally established in 1961.

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Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

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Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

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Chemical synthesis

Chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products.

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Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.

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Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. Androstenediol and Dehydroepiandrosterone are anabolic–androgenic steroids, Androstanes, estrogens and Pregnane X receptor agonists.

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Derivative (chemistry)

In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Androstenediol and Estradiol are estrogens.

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Estrane

Estrane is a C18 steroid derivative, with a gonane core.

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Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Androstenediol and Estrogen are estrogens.

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Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein) that is activated by the sex hormone estrogen.

See Androstenediol and Estrogen receptor alpha

Estrogen receptor beta

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.

See Androstenediol and Estrogen receptor beta

Ethinylandrostenediol

Ethinylandrostenediol (developmental code name SKF-2856), also known as 17α-ethynyl-5-androstenediol, is a synthetic estrogen, progestogen, and androgen which was never marketed. Androstenediol and Ethinylandrostenediol are anabolic–androgenic steroids and Androstanes.

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Immune system

The immune system is a network of biological systems that protects an organism from diseases.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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Ionizing radiation

Ionizing radiation (US, ionising radiation in the UK), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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List of androgen esters

This is a list of androgen esters, including esters (as well as ethers) of natural androgens like testosterone and dihydrotestosterone (DHT) and synthetic anabolic–androgenic steroids (AAS) like nandrolone (19-nortestosterone). Androstenediol and list of androgen esters are anabolic–androgenic steroids.

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Methandriol

Methandriol (brand names Anabol, Crestabolic, Cytobolin, Diandren, Durabolic, Madiol, Mestenediol, Methabolic, Methydiol, Sterabolic, Stenediol), also known as methylandrostenediol, is an androgen and anabolic steroid (AAS) medication which was developed by Organon and is used in both oral and injectable (as methandriol dipropionate, methandriol propionate, or methandriol bisenanthoyl acetate) formulations. Androstenediol and methandriol are anabolic–androgenic steroids and Androstanes.

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Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

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Oral administration

| name.

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Placebo

A placebo is a substance or treatment which is designed to have no therapeutic value.

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Platelet

Platelets or thrombocytes are a blood component whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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Rat

Rats are various medium-sized, long-tailed rodents.

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Reaction intermediate

In chemistry, a reaction intermediate, or intermediate, is a molecular entity arising within the sequence of a stepwise chemical reaction.

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Rhesus macaque

The rhesus macaque (Macaca mulatta), colloquially rhesus monkey, is a species of Old World monkey.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Steroid hormone

A steroid hormone is a steroid that acts as a hormone.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Testosterone

Testosterone is the primary male sex hormone and androgen in males. Androstenediol and Testosterone are anabolic–androgenic steroids, Androstanes and estrogens.

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United States Department of Health and Human Services

The United States Department of Health and Human Services (HHS) is a cabinet-level executive branch department of the U.S. federal government created to protect the health of the U.S. people and providing essential human services.

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White blood cell

White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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17α-Alkylated anabolic steroid

A 17α-alkylated anabolic steroid is a synthetic anabolic–androgenic steroid (AAS) that features an alkyl group, specifically a methyl or ethyl group, at the C17α position. Androstenediol and 17α-Alkylated anabolic steroid are anabolic–androgenic steroids.

See Androstenediol and 17α-Alkylated anabolic steroid

19-Nor-5-androstenediol

19-Nor-5-androstenediol, also known as estr-5-ene-3β,17β-diol, is a synthetic, orally active anabolic-androgenic steroid (AAS) and a derivative of 19-nortestosterone (nandrolone) that was never introduced for medical use. Androstenediol and 19-Nor-5-androstenediol are anabolic–androgenic steroids and estrogens.

See Androstenediol and 19-Nor-5-androstenediol

3β-Androstanediol

3β-Androstanediol, also known as 5α-androstane-3β,17β-diol, and sometimes shortened in the literature to 3β-diol, is an endogenous steroid hormone and a metabolite of androgens like dehydroepiandrosterone (DHEA) and dihydrotestosterone (DHT). Androstenediol and 3β-Androstanediol are Androstanes, estrogens and Selective ERβ agonists.

See Androstenediol and 3β-Androstanediol

4-Androstenediol

4-Androstenediol, also known as androst-4-ene-3β,17β-diol, is an androstenediol that is converted to testosterone. Androstenediol and 4-Androstenediol are anabolic–androgenic steroids, Androstanes and estrogens.

See Androstenediol and 4-Androstenediol

References

[1] https://en.wikipedia.org/wiki/Androstenediol

Also known as 5-AED, 5-Androstene-3,17-diol, 5-Androstenediol, HE 2100, HE-2100, HE2100, Hermaphrodiol, Neumune, Δ5-Androstenediol, Δ5-diol.

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Androstenediol

Table of Contents

See also

Pregnane X receptor agonists

Selective ERβ agonists

References