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Androstenedione

Index Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA). [1]

Table of Contents

  1. 72 relations: Adrenal gland, Adrenarche, Adrenocorticotropic hormone, Anabolic steroid, Androgen, Androstane, Androstanedione, Androstenediol, Androsterone, Aromatase, Barry McCaffrey, Biological activity, Biosynthesis, Blood plasma, Clitoromegaly, CNBC, Controlled substance, Controlled Substances Act, Cortisol, CYP17A1, Dehydroepiandrosterone, Desiccated thyroid extract, Dietary supplement, Endogeny (biology), Estradiol, Estrogen, Estrogen receptor, Estrogen receptor alpha, Estrogen receptor beta, Estrone, Food and Drug Administration, Gonad, Gonadotropin, Granulosa cell, Ketosteroid, Ligand (biochemistry), Liver, Major League Baseball, Mark McGwire, Mayo Clinic, Menopause, Metabolite, Natural product, Neurosteroid, Office of National Drug Control Policy, Olympic Games, Oral administration, Ovary, Over-the-counter drug, Patrick Arnold, ... Expand index (22 more) »

  2. Pregnane X receptor agonists

Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

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Adrenarche

Adrenarche is an early stage in sexual maturation that happens in some higher primates (including humans), typically peaks at around 20 years of age, and is involved in the development of pubic hair, body odor, skin oiliness, axillary hair, sexual attraction/sexual desire/increased libido and mild acne.

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Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

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Anabolic steroid

Anabolic steroids, also known as anabolic-androgenic steroids (AAS), are a class of drugs that are structurally related to testosterone, the main male sex hormone, and produce effects by binding to the androgen receptor (AR). Androstenedione and anabolic steroid are Anabolic–androgenic steroids.

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Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. Androstenedione and androgen are Anabolic–androgenic steroids.

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Androstane

Androstane is a C19 steroidal hydrocarbon with a gonane core. Androstenedione and Androstane are Anabolic–androgenic steroids and androstanes.

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Androstanedione

Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a naturally occurring androstane (5α-androstane) steroid and an endogenous metabolite of androgens like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione. Androstenedione and Androstanedione are Anabolic–androgenic steroids, androstanes and Diketones.

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Androstenediol

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). Androstenedione and Androstenediol are Anabolic–androgenic steroids, androstanes, estrogens and pregnane X receptor agonists.

See Androstenedione and Androstenediol

Androsterone

Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. Androstenedione and Androsterone are Anabolic–androgenic steroids and androstanes.

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Aromatase

Aromatase, also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens.

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Barry McCaffrey

Barry Richard McCaffrey (born November 17, 1942) is a retired United States Army general and current news commentator, professor and business consultant who served in President Bill Clinton's Cabinet as the Director of the Office of National Drug Control Policy.

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Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

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Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

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Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.

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Clitoromegaly

Clitoromegaly (or macroclitoris) is an abnormal enlargement of the clitoris that is mostly congenital; it is otherwise acquired through deliberately induced clitoral enlargement e.g. body modification by use of anabolic steroids, including testosterone.

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CNBC

CNBC is an American business news channel owned by NBCUniversal News Group, a unit of Comcast's NBCUniversal.

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Controlled substance

A controlled substance is generally a drug or chemical whose manufacture, possession and use is regulated by a government, such as illicitly used drugs or prescription medications that are designated by law.

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Controlled Substances Act

The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.

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Cortisol

Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.

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CYP17A1

Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.

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Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. Androstenedione and Dehydroepiandrosterone are Anabolic–androgenic steroids, androstanes, estrogens and pregnane X receptor agonists.

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Desiccated thyroid extract

Desiccated thyroid extract (DTE), is thyroid gland that has been dried and powdered for medical use.

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Dietary supplement

A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill, capsule, tablet, powder, or liquid.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Androstenedione and Estradiol are estrogens.

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Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Androstenedione and Estrogen are estrogens.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein) that is activated by the sex hormone estrogen.

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Estrogen receptor beta

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. Androstenedione and Estrone are estrogens.

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Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

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Gonad

A gonad, sex gland, or reproductive gland is a mixed gland that produces the gametes and sex hormones of an organism.

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Gonadotropin

Gonadotropins are glycoprotein hormones secreted by gonadotropic cells of the anterior pituitary of vertebrates.

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Granulosa cell

A granulosa cell or follicular cell is a somatic cell of the sex cord that is closely associated with the developing female gamete (called an oocyte or egg) in the ovary of mammals.

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Ketosteroid

Androstenedione Androsterone Estrone A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

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Major League Baseball

Major League Baseball (MLB) is a professional baseball league and the highest level of organized baseball in the United States and Canada.

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Mark McGwire

Mark David McGwire (born October 1, 1963), nicknamed "Big Mac", is an American former professional baseball first baseman who played 16 seasons in Major League Baseball (MLB) from 1986 to 2001 for the Oakland Athletics and the St. Louis Cardinals.

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Mayo Clinic

Mayo Clinic is a nonprofit American academic medical center focused on integrated health care, education, and research.

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Menopause

Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of reproduction.

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

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Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.

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Office of National Drug Control Policy

The Office of National Drug Control Policy (ONDCP) is a component of the Executive Office of the President of the United States.

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Olympic Games

The modern Olympic Games or Olympics (Jeux olympiques) are the leading international sporting events featuring summer and winter sports competitions in which thousands of athletes from around the world participate in a variety of competitions.

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Oral administration

| name.

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Ovary

The ovary is a gonad in the female reproductive system that produces ova.

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Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescription.

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Patrick Arnold

Patrick Arnold (born 1966) is an American organic chemist known for introducing androstenedione, 1-androstenediol, and methylhexanamine into the dietary supplement market, and for creating the designer steroid tetrahydrogestrinone, also known as THG and "the clear".

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Precursor (chemistry)

In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.

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Pregnenolone

Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. Androstenedione and Pregnenolone are pregnane X receptor agonists.

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Prohormone

A prohormone is a committed precursor of a hormone consisting of peptide hormones synthesized together that has a minimal hormonal effect by itself because of its expression-suppressing structure, often created by protein folding and binding additional peptide chains to certain ends, that makes hormone receptor binding sites located on its peptide hormone chain segments inaccessible.

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Reaction intermediate

In chemistry, a reaction intermediate, or intermediate, is a molecular entity arising within the sequence of a stepwise chemical reaction.

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Sex hormone

Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors.

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Sports Illustrated

Sports Illustrated (SI) is an American sports magazine first published in August 1954.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Steroid hormone

A steroid hormone is a steroid that acts as a hormone.

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Strength training

Strength training, also known as weight training or resistance training, involves the performance of physical exercises that are designed to improve strength and endurance.

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Testosterone

Testosterone is the primary male sex hormone and androgen in males. Androstenedione and Testosterone are Anabolic–androgenic steroids, androstanes and estrogens.

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Testosterone (medication)

Testosterone (T) is a medication and naturally occurring steroid hormone. Androstenedione and Testosterone (medication) are Anabolic–androgenic steroids, androstanes and estrogens.

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Thailand

Thailand, officially the Kingdom of Thailand and historically known as Siam (the official name until 1939), is a country in Southeast Asia on the Indochinese Peninsula.

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Theca of follicle

The theca folliculi comprise a layer of the ovarian follicles.

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Thyroid hormones

Thyroid hormones are any hormones produced and released by the thyroid gland, namely triiodothyronine (T3) and thyroxine (T4).

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United States Armed Forces

The United States Armed Forces are the military forces of the United States.

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White House

The White House is the official residence and workplace of the president of the United States.

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World Anti-Doping Agency

The World Anti-Doping Agency (WADA; Agence mondiale antidopage, AMA) is a foundation initiated by the International Olympic Committee based in Canada to promote, coordinate, and monitor the fight against drugs in sports.

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17α-Hydroxypregnenolone

17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. Androstenedione and 17α-Hydroxypregnenolone are pregnane X receptor agonists.

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17α-Hydroxyprogesterone

17α-Hydroxyprogesterone (17α-OHP), also known as 17-OH progesterone (17-OHP), or hydroxyprogesterone (OHP), is an endogenous progestogen steroid hormone related to progesterone. Androstenedione and 17α-Hydroxyprogesterone are Diketones and pregnane X receptor agonists.

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17β-Hydroxysteroid dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.

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3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

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5α-Reductase

5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.

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See also

Pregnane X receptor agonists

References

[1] https://en.wikipedia.org/wiki/Androstenedione

Also known as 4-Androsten-3,17-dione, 4-Androstene-3,17-dione, 4-Androstenedione, Androst-4-en-3,17-dione, Androst-4-ene-3,17-dione, Androstendione, Δ4-Androstenedione.

, Precursor (chemistry), Pregnenolone, Prohormone, Reaction intermediate, Sex hormone, Sports Illustrated, Steroid, Steroid hormone, Strength training, Testosterone, Testosterone (medication), Thailand, Theca of follicle, Thyroid hormones, United States Armed Forces, White House, World Anti-Doping Agency, 17α-Hydroxypregnenolone, 17α-Hydroxyprogesterone, 17β-Hydroxysteroid dehydrogenase, 3β-Hydroxysteroid dehydrogenase, 5α-Reductase.