32 relations: Adaptive immune system, Antigen, Antigen presentation, Antigen processing, Artificial antigen presenting cells, Autoimmune disease, B cell, Beta-2 microglobulin, Cancer, CD1, CD28, CD40 (protein), Cell (biology), Cross-presentation, Cytotoxic T cell, Dendritic cell, Epitope, IMP321, Lipid, Lymph node, Lymphatic vessel, Macrophage, Major histocompatibility complex, Natural killer cell, Pattern recognition receptor, Peripheral tolerance, Phagocytosis, Receptor-mediated endocytosis, T cell, T helper cell, T-cell receptor, The Proteolysis Map.
The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth.
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.
Antigen presentation describes a vital immune process which is essential for T cell immune response triggering.
Antigen processing is an immunological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes.
Artificial antigen presenting cells (aAPCs) are a new technology and approach to cancer immunotherapy.
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α1, α2, and α3 proteins which are present on all nucleated cells (excludes red blood cells).
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival.
Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation.
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
Cross-presentation is the ability of certain antigen-presenting cells to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells).
A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.
IMP321 is a large molecule cancer drug being developed by the clinical stage biotechnology company Prima BioMed (Nasdaq: IMMP).
In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.
A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.
The lymphatic vessels (or lymph vessels or lymphatics) are thin-walled vessels structured like blood vessels, that carry lymph.
Macrophages (big eaters, from Greek μακρός (makrós).
The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.
Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.
Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system.
Peripheral tolerance is the second branch of immunological tolerance, after central tolerance.
In cell biology, phagocytosis is the process by which a cell—often a phagocyte or a protist—engulfs a solid particle to form an internal compartment known as a phagosome.
Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, other proteins – and in some cases viruses – by the inward budding of plasma membrane vesicles containing proteins with receptor sites specific to the molecules being absorbed (endocytosis).
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.
The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
The Proteolysis MAP (PMAP) is an integrated web resource focused on proteases.