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Antihypertensive drug

Index Antihypertensive drug

Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). [1]

163 relations: ACE inhibitor, ACE inhibitor and thiazide combination, Aldosterone, Aliskiren, Alpha blocker, Alpha-2 adrenergic receptor, American Heart Association, Amiloride, Amlodipine, Angioedema, Angiotensin, Angiotensin II receptor, Angiotensin II receptor blocker, Angiotensin-converting enzyme, Anxiety, Aortic dissection, Asthma, Atenolol, Autoreceptor, Azilsartan, Benazepril, Bendroflumethiazide, Benign prostatic hyperplasia, Beta blocker, Betaxolol, Bisoprolol, Blood pressure, Bosentan, Bucindolol, Bumetanide, Calcium channel blocker, Candesartan, Captopril, Cardiovascular disease, Carteolol, Carvedilol, Chlorothiazide, Chlortalidone, Chronic kidney disease, Cilnidipine, Circulation (journal), Clevidipine, Clinical endpoint, Clonidine, Combination drug, Coronary artery disease, Cough, CYT006-AngQb, Death, Dementia, ..., Diabetes mellitus, Diabetes mellitus type 2, Dihydropyridine, Diltiazem, Diuretic, Doxazosin, Enalapril, Endothelin, Epitizide, Eplerenone, Eprosartan, Etacrynic acid, Ethnic group, Evidence-based medicine, Felodipine, Fimasartan, Fosinopril, Furosemide, Gestational hypertension, Gout, Guanabenz, Guanethidine, Guanfacine, Heart block, Heart failure, Hormone, Hydralazine, Hydrochlorothiazide, Hyperaldosteronism, Hypercholesterolemia, Hyperkalemia, Hypertension, Hypertensive emergency, Impaired glucose tolerance, Indapamide, Indoramin, Irbesartan, Isradipine, JAMA (journal), Kidney, Kidney stone disease, Labetalol, Lercanidipine, Levamlodipine, Lisinopril, Loop diuretic, Losartan, Mayo Clinic, McGraw-Hill Education, Mecamylamine, Medication, Methyclothiazide, Methyldopa, Metolazone, Metoprolol, Minoxidil, Moexipril, Moxonidine, Myocardial infarction, Nadolol, National Institute for Health and Care Excellence, Nebivolol, Negative feedback, Nicardipine, Nicotinic antagonist, Nifedipine, Nimodipine, Nisoldipine, Nitrendipine, Olmesartan, Oxprenolol, Penbutolol, Perindopril, Phenoxybenzamine, Phentolamine, Pindolol, Polythiazide, Potassium-sparing diuretic, Prazosin, Propranolol, Pulmonary artery, Quinapril, Ramipril, Receptor antagonist, Renal function, Renin, Renin inhibitor, Renin–angiotensin system, Reserpine, Retina, Smooth muscle tissue, Sodium nitroprusside, Spironolactone, Stroke, Telmisartan, Terazosin, The BMJ, The Lancet, The New England Journal of Medicine, Therapy, Thiazide, Timolol, Tolazoline, Tonic (physiology), Torasemide, Trandolapril, Tremor, Triamterene, Valsartan, Vasoconstriction, Vasodilation, Verapamil, Vesicular monoamine transporter. Expand index (113 more) »

ACE inhibitor

An angiotensin-converting-enzyme inhibitor (ACE inhibitor) is a pharmaceutical drug used primarily for the treatment of hypertension (elevated blood pressure) and congestive heart failure.

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ACE inhibitor and thiazide combination

An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension.

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Aldosterone

Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.

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Aliskiren

Aliskiren (trade names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors.

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Alpha blocker

Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).

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Alpha-2 adrenergic receptor

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.

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American Heart Association

The American Heart Association (AHA) is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke.

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Amiloride

Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver.

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Amlodipine

Amlodipine, sold under the brand name Norvasc among others, is a medication used to treat high blood pressure and coronary artery disease.

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Angioedema

Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes.

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Angiotensin

Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure.

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Angiotensin II receptor

The angiotensin II receptors, (AGTR1) and (AGTR2), are a class of G protein-coupled receptors with angiotensin II as their ligands.

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Angiotensin II receptor blocker

Angiotensin II receptor blockers (ARBs), also known as angiotensin II receptor antagonists, AT1 receptor antagonists or sartans, are a group of pharmaceuticals that modulate the renin–angiotensin system.

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Angiotensin-converting enzyme

Angiotensin-converting enzyme, or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body.

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Anxiety

Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.

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Aortic dissection

Aortic dissection (AD) occurs when an injury to the innermost layer of the aorta allows blood to flow between the layers of the aortic wall, forcing the layers apart.

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Asthma

Asthma is a common long-term inflammatory disease of the airways of the lungs.

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Atenolol

Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers (sometimes written β-blockers), a class of drugs used primarily in cardiovascular diseases.

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Autoreceptor

An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.

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Azilsartan

Azilsartan (INN) is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda.

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Benazepril

Benazepril, brand name Lotensin (Novartis), is an ACE inhibitor used primarily in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing the renal and retinal complications of diabetes.

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Bendroflumethiazide

Bendroflumethiazide (INN), formerly bendrofluazide (BAN), trade name Aprinox, is a thiazide diuretic used to treat hypertension.

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Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate.

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Beta blocker

Beta blockers, also written β-blockers, are a class of medications that are particularly used to manage abnormal heart rhythms, and to protect the heart from a second heart attack (myocardial infarction) after a first heart attack (secondary prevention).

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Betaxolol

Betaxolol (trade names Betoptic, Betoptic S, Lokren, Kerlone) is a selective beta1 receptor blocker used in the treatment of hypertension and glaucoma.

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Bisoprolol

Bisoprolol, marketed under the tradename Zebeta among others, is a medication most commonly used for heart diseases.

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Blood pressure

Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.

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Bosentan

Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension (PAH).

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Bucindolol

Bucindolol is a non-selective beta blocker with additional weak alpha-blocking properties and some intrinsic sympathomimetic activity.

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Bumetanide

Bumetanide (trade names Bumex or Burinex) is a loop diuretic of the sulfamyl category, most often used to treat heart failure.

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Calcium channel blocker

Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium through calcium channels.

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Candesartan

Candesartan (rINN) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

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Captopril

Captopril, sold under the trade name Capoten, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.

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Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.

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Carteolol

Carteolol (trade names Cartrol, Ocupress, Teoptic, Arteolol, Arteoptic, Calte, Cartéabak, Carteol, Cartéol, Cartrol, Elebloc, Endak, Glauteolol, Mikelan, Poenglaucol, Singlauc) is a non-selective beta blocker used to treat glaucoma.

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Carvedilol

Carvedilol, sold under the brand name Coreg among others, is a medication used for treating mild to severe congestive heart failure (CHF), left ventricular dysfunction (LVD) following heart attack in people who are otherwise stable, and for treating high blood pressure.

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Chlorothiazide

Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive.

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Chlortalidone

Chlortalidone (INN/BAN) or chlorthalidone (USAN) is a diuretic medication used to treat hypertension (high blood pressure), originally marketed as Hygroton in the USA.

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Chronic kidney disease

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months or years.

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Cilnidipine

Cilnidipine (INN) is a calcium channel blocker.

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Circulation (journal)

Circulation is a scientific journal published by Lippincott Williams & Wilkins for the American Heart Association.

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Clevidipine

Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable.

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Clinical endpoint

In a clinical research trial, a clinical endpoint generally refers to occurrence of a disease, symptom, sign or laboratory abnormality that constitutes one of the target outcomes of the trial, but may also refer to any such disease or sign that strongly motivates the withdrawal of that individual or entity from the trial, then often termed humane (clinical) endpoint.

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Clonidine

Clonidine (trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, tic disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions.

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Combination drug

A combination drug is a fixed-dose combination (FDC) that includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in fixed doses.

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Coronary artery disease

Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.

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Cough

A cough is a sudden and often repetitively occurring, protective reflex, which helps to clear the large breathing passages from fluids, irritants, foreign particles and microbes.

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CYT006-AngQb

CYT006-AngQb was an investigational vaccine against angiotensin II, designed to lower blood pressure.

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Death

Death is the cessation of all biological functions that sustain a living organism.

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Dementia

Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.

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Diabetes mellitus

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.

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Diabetes mellitus type 2

Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

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Dihydropyridine

Dihydropyridine is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond.

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Diltiazem

Diltiazem (INN) is a nondihydropyridine (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.

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Diuretic

A diuretic is any substance that promotes diuresis, the increased production of urine.

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Doxazosin

Doxazosin mesylate, a quinazoline compound sold by Pfizer under the brand names Cardura and Carduran, is an α1-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH).

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Enalapril

Enalapril, sold under the brand name Vasotec among others, is a medication used to treat high blood pressure, diabetic kidney disease, and heart failure.

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Endothelin

Endothelins are peptides with receptors and effects in many body organs.

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Epitizide

Epitizide is a diuretic.

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Eplerenone

Eplerenone is a steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure.

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Eprosartan

Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure.

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Etacrynic acid

Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure.

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Ethnic group

An ethnic group, or an ethnicity, is a category of people who identify with each other based on similarities such as common ancestry, language, history, society, culture or nation.

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Evidence-based medicine

Evidence-based medicine (EBM) is an approach to medical practice intended to optimize decision-making by emphasizing the use of evidence from well-designed and well-conducted research.

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Felodipine

Felodipine is a medication of the calcium channel blocker type which is used to treat high blood pressure.

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Fimasartan

Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure.

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Fosinopril

Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure.

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Furosemide

Furosemide, sold under the brand name Lasix among others, is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.

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Gestational hypertension

Gestational hypertension or pregnancy-induced hypertension (PIH) is the development of new hypertension in a pregnant woman after 20 weeks' gestation without the presence of protein in the urine or other signs of pre-eclampsia.

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Gout

Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint.

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Guanabenz

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 adrenergic receptor that is used as an antihypertensive drug.

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Guanethidine

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.

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Guanfacine

Guanfacine (trade names Estulic, Tenex, and, in extended release form, Intuniv) is a sympatholytic drug used to treat hypertension and attention deficit hyperactivity disorder (ADHD).

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Heart block

Heart block is a disease or inherited condition that causes a fault within the heart's natural pacemaker due to some kind of obstruction (or "block") in the electrical conduction system of the heart.

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Heart failure

Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.

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Hormone

A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Hydralazine

Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure.

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Hydrochlorothiazide

Hydrochlorothiazide (HCTZ or HCT) is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.

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Hyperaldosteronism

Hyperaldosteronism, also aldosteronism, is a medical condition wherein too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood (hypokalemia) and increased hydrogen ion excretion (alkalosis).

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Hypercholesterolemia

Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood.

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Hyperkalemia

Hyperkalemia, also spelled hyperkalaemia, is an elevated level of potassium (K+) in the blood serum.

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Hypertension

Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Hypertensive emergency

A hypertensive emergency, also known as malignant hypertension, is high blood pressure with potentially life-threatening symptoms and signs indicative of acute impairment of one or more organ systems (especially the central nervous system, cardiovascular system or the kidneys).

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Impaired glucose tolerance

Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology.

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Indapamide

Indapamide is a thiazide-like diuretic drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure.

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Indoramin

Indoramin (trade names Baratol and Doralese) is a piperidine antiadrenergic agent.

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Irbesartan

Irbesartan (INN) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

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Isradipine

Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class.

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JAMA (journal)

JAMA: The Journal of the American Medical Association is a peer-reviewed medical journal published 48 times a year by the American Medical Association.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Kidney stone disease

Kidney stone disease, also known as urolithiasis, is when a solid piece of material (kidney stone) occurs in the urinary tract.

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Labetalol

Labetalol is a medication used to treat high blood pressure.

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Lercanidipine

Lercanidipine (trade name Zanidip, among others) is an antihypertensive (blood pressure lowering) drug.

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Levamlodipine

Levamlodipine (INN), also known as levoamlodipine or S-amlodipine is a pharmacologically active enantiomer of amlodipine.

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Lisinopril

Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class used primarily in treatment of high blood pressure, heart failure, and after heart attacks.

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Loop diuretic

Loop diuretics are diuretics that act at the ascending limb of the loop of Henle in the kidney.

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Losartan

Losartan, sold under the trade name Cozaar among others, is a medication mainly used to treat high blood pressure.

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Mayo Clinic

The Mayo Clinic is a nonprofit academic medical center based in Rochester, Minnesota focused on integrated clinical practice, education, and research.

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McGraw-Hill Education

McGraw-Hill Education (MHE) is a learning science company and one of the "big three" educational publishers that provides customized educational content, software, and services for pre-K through postgraduate education.

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Mecamylamine

Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs) that was introduced in the 1950s as an antihypertensive drug.

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Medication

A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Methyclothiazide

Methyclothiazide is a thiazide diuretic.

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Methyldopa

Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure.

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Metolazone

Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox.

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Metoprolol

Metoprolol, marketed under the tradename Lopressor among others, is a medication of the selective β1 receptor blocker type.

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Minoxidil

No description.

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Moexipril

Moexipril hydrochloride is a potent orally active nonsulfhydryl angiotensin converting enzyme inhibitor (ACE inhibitor) which is used for the treatment of hypertension and congestive heart failure.

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Moxonidine

Moxonidine (INN) is a new-generation alpha-2/imidazoline receptor agonist antihypertensive drug licensed for the treatment of mild to moderate essential hypertension.

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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Nadolol

Nadolol (Corgard) is a non-selective beta blocker used in the treatment of high blood pressure and chest pain.

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National Institute for Health and Care Excellence

The National Institute for Health and Care Excellence (NICE) is an executive non-departmental public body of the Department of Health in the United Kingdom, which publishes guidelines in four areas.

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Nebivolol

Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure.

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Negative feedback

Negative feedback (or balancing feedback) occurs when some function of the output of a system, process, or mechanism is fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances.

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Nicardipine

Nicardipine (Cardene) is a medication used to treat high blood pressure and angina.

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Nicotinic antagonist

A nicotinic antagonist is a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors.

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Nifedipine

Nifedipine, sold under the brand names Adalat among others, is a medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor.

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Nimodipine

Nimodipine (marketed by Bayer as Nimotop) is a dihydropyridine calcium channel blocker originally developed for the treatment of high blood pressure.

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Nisoldipine

Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class.

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Nitrendipine

Nitrendipine is a dihydropyridine calcium channel blocker.

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Olmesartan

Olmesartan medoxomil is an angiotensin II receptor antagonist which is used for the treatment of high blood pressure.

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Oxprenolol

Oxprenolol (brand names Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity.

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Penbutolol

Penbutolol (brand names Levatol, Levatolol, Lobeta, Paginol, Hostabloc, Betapressin) is a medication in the class of beta blockers, used in the treatment of high blood pressure.

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Perindopril

Perindopril is a long-acting ACE inhibitor used to treat high blood pressure, heart failure, or stable coronary artery disease in form of perindopril arginine (trade names include Coversyl, Coversum) or perindopril erbumine (Aceon).

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Phenoxybenzamine

Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-selective, irreversible alpha blocker.

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Phentolamine

Phentolamine (Regitine) is a reversible nonselective α-adrenergic antagonist.

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Pindolol

Pindolol, sold under the brand name Visken among others, is a beta blocker which is used in the treatment of hypertension and angina pectoris.

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Polythiazide

Polythiazide is a thiazide diuretic.

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Potassium-sparing diuretic

Potassium-sparing diuretics are diuretic drugs that do not promote the secretion of potassium into the urine.

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Prazosin

Prazosin, trade names Minipress, Vasoflex, Lentopres and Hypovase, is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD).

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Propranolol

Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker type. It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors. It is used to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks. It can be taken by mouth or by injection into a vein. The formulation that is taken by mouth comes in short-acting and long-acting versions. Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minutes when taken by mouth. Common side effects include nausea, abdominal pain, and constipation. It should not be used in those with an already slow heart rate and most of those with heart failure. Quickly stopping the medication in those with coronary artery disease may worsen symptoms. It may worsen the symptoms of asthma. Caution is recommended in those with liver or kidney problems. Propranolol may cause harmful effects in the baby if taken during pregnancy. Its use during breastfeeding is probably safe, but the baby should be monitored for side effects. It is a non-selective beta blocker which works by blocking β-adrenergic receptors. Propranolol was discovered in 1964. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Propranolol is available as a generic medication. The wholesale cost in the developing world is between 0.24 and 2.16 per month as of 2014. In the United States it costs about $15 per month at a typical dose.

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Pulmonary artery

A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs.

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Quinapril

Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure.

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Ramipril

Ramipril, sold under the brand name Altace among others, is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Renal function

Renal function, in nephrology, is an indication of the kidney's condition and its role in renal physiology.

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Renin

Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.

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Renin inhibitor

Renin inhibitors are a group of pharmaceutical drugs used primarily in treatment of essential hypertension (high blood pressure).

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Renin–angiotensin system

The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that regulates blood pressure and fluid balance.

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Reserpine

Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, Major Types Of Chemical Compounds In Plants & Animals Part II: Phenolic Compounds, Glycosides & Alkaloids. Wayne's Word: An On-Line Textbook of Natural History.

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Retina

The retina is the innermost, light-sensitive "coat", or layer, of shell tissue of the eye of most vertebrates and some molluscs.

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Smooth muscle tissue

Smooth muscle is an involuntary non-striated muscle.

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Sodium nitroprusside

Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure.

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Spironolactone

Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.

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Stroke

A stroke is a medical condition in which poor blood flow to the brain results in cell death.

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Telmisartan

Telmisartan (INN) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension.

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Terazosin

Terazosin (marketed as Hytrin or Zayasel) is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH).

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The BMJ

The BMJ is a weekly peer-reviewed medical journal.

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The Lancet

The Lancet is a weekly peer-reviewed general medical journal.

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The New England Journal of Medicine

The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society.

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Therapy

Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.

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Thiazide

Thiazide is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) and edema (such as that caused by heart failure, liver failure, or kidney failure).

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Timolol

Timolol is a medication used either by mouth or as eye drops.

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Tolazoline

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist.

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Tonic (physiology)

Tonic in physiology refers to a physiological response which is slow and may be graded.

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Torasemide

Torasemide or torsemide is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure.

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Trandolapril

Trandolapril is an ACE inhibitor used to treat high blood pressure, it may also be used to treat other conditions.

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Tremor

A tremor is an involuntary, somewhat rhythmic, muscle contraction and relaxation involving oscillations or twitching movements of one or more body parts.

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Triamterene

Triamterene (trade name Dyrenium) is a potassium-sparing diuretic used in combination with thiazide diuretics for the treatment of hypertension and edema.

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Valsartan

Valsartan (trade name Diovan) is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack.

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Vasoconstriction

Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.

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Vasodilation

Vasodilation is the widening of blood vessels.

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Verapamil

Verapamil, sold under various trade names, is a medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia.

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Vesicular monoamine transporter

The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membrane of synaptic vesicles of presynaptic neurons.

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References

[1] https://en.wikipedia.org/wiki/Antihypertensive_drug

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