Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Android™ device!
Download
Faster access than browser!
 

Apolipoprotein E

+ Save concept

Apolipoprotein E (ApoE) is a class of proteins involved in the metabolism of fats in the body. [1]

79 relations: Allele, Allele frequency, Alzheimer's disease, Amino acid, Amphiphile, Amyloid, Amyloid beta, Apolipoprotein, Apolipoprotein C1, Apolipoprotein C2, Astrocyte, Atherosclerosis, Base pair, Blood–brain barrier, Brain, Cardiovascular disease, Catabolism, CD1, Central nervous system, Cerebrovascular disease, Cholesterol, Chromosome 19, Chylomicron, Cognition, Exon, Familial dysbetalipoproteinemia, Fatty acid, Genetic disorder, Glucose, Hippocampus, HIV, Homeostasis, Hydrogen bond, Hydrophobe, Hypercholesterolemia, Hyperlipidemia, Immune system, Inflammation, Intermediate-density lipoprotein, Intron, Kidney, Knockout mouse, LDL receptor, Lipid, Liver, Liver X receptor, Low-density lipoprotein, Low-density lipoprotein receptor gene family, Lymphatic system, Macrophage, ..., Malaria, Melanocyte, Metabolism, Microglia, Microphthalmia-associated transcription factor, Multiple sclerosis, Natural killer T cell, Neurite, Neuron, Nuclear receptor, Parkinson's disease, Peptide, Peroxisome proliferator-activated receptor, Polymorphism (biology), Protein dimer, Protein isoform, Proteolysis, Receptor (biochemistry), Redox, Retinoid X receptor, Sleep apnea, Spleen, T cell, Telomere, Traumatic brain injury, Triglyceride, Very low-density lipoprotein, Vitamin, Vitamin D. Expand index (29 more) »

Allele

An allele is a variant form of a given gene.

New!!: Apolipoprotein E and Allele · See more »

Allele frequency

Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage.

New!!: Apolipoprotein E and Allele frequency · See more »

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

New!!: Apolipoprotein E and Alzheimer's disease · See more »

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

New!!: Apolipoprotein E and Amino acid · See more »

Amphiphile

An amphiphile (from the Greek αμφις, amphis: both and φιλíα, philia: love, friendship) is a chemical compound possessing both hydrophilic (water-loving, polar) and lipophilic (fat-loving) properties.

New!!: Apolipoprotein E and Amphiphile · See more »

Amyloid

Amyloids are aggregates of proteins that become folded into a shape that allows many copies of that protein to stick together forming fibrils.

New!!: Apolipoprotein E and Amyloid · See more »

Amyloid beta

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients.

New!!: Apolipoprotein E and Amyloid beta · See more »

Apolipoprotein

Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins.

New!!: Apolipoprotein E and Apolipoprotein · See more »

Apolipoprotein C1

Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene.

New!!: Apolipoprotein E and Apolipoprotein C1 · See more »

Apolipoprotein C2

Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

New!!: Apolipoprotein E and Apolipoprotein C2 · See more »

Astrocyte

Astrocytes (Astro from Greek astron.

New!!: Apolipoprotein E and Astrocyte · See more »

Atherosclerosis

Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.

New!!: Apolipoprotein E and Atherosclerosis · See more »

Base pair

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.

New!!: Apolipoprotein E and Base pair · See more »

Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).

New!!: Apolipoprotein E and Blood–brain barrier · See more »

Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

New!!: Apolipoprotein E and Brain · See more »

Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.

New!!: Apolipoprotein E and Cardiovascular disease · See more »

Catabolism

Catabolism (from Greek κάτω kato, "downward" and βάλλειν ballein, "to throw") is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions.

New!!: Apolipoprotein E and Catabolism · See more »

CD1

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

New!!: Apolipoprotein E and CD1 · See more »

Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

New!!: Apolipoprotein E and Central nervous system · See more »

Cerebrovascular disease

Cerebrovascular disease includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation.

New!!: Apolipoprotein E and Cerebrovascular disease · See more »

Cholesterol

Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.

New!!: Apolipoprotein E and Cholesterol · See more »

Chromosome 19

Chromosome 19 is one of the 23 pairs of chromosomes in humans.

New!!: Apolipoprotein E and Chromosome 19 · See more »

Chylomicron

Chylomicrons (from the Greek χυλός, chylos, meaning juice (of plants or animals), and micron, meaning small particle) are lipoprotein particles that consist of triglycerides (85–92%), phospholipids (6–12%), cholesterol (1–3%), and proteins (1–2%).

New!!: Apolipoprotein E and Chylomicron · See more »

Cognition

Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

New!!: Apolipoprotein E and Cognition · See more »

Exon

An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

New!!: Apolipoprotein E and Exon · See more »

Familial dysbetalipoproteinemia

Familial dysbetalipoproteinemia or type III hyperlipoproteinemia (also known as remnant hyperlipidemia, "remnant hyperlipoproteinaemia", "broad beta disease" and "remnant removal disease") is a condition characterized by increased total cholesterol and triglyceride levels, and decreased HDL levels.

New!!: Apolipoprotein E and Familial dysbetalipoproteinemia · See more »

Fatty acid

In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated.

New!!: Apolipoprotein E and Fatty acid · See more »

Genetic disorder

A genetic disorder is a genetic problem caused by one or more abnormalities in the genome.

New!!: Apolipoprotein E and Genetic disorder · See more »

Glucose

Glucose is a simple sugar with the molecular formula C6H12O6.

New!!: Apolipoprotein E and Glucose · See more »

Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

New!!: Apolipoprotein E and Hippocampus · See more »

HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

New!!: Apolipoprotein E and HIV · See more »

Homeostasis

Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.

New!!: Apolipoprotein E and Homeostasis · See more »

Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

New!!: Apolipoprotein E and Hydrogen bond · See more »

Hydrophobe

In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.

New!!: Apolipoprotein E and Hydrophobe · See more »

Hypercholesterolemia

Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood.

New!!: Apolipoprotein E and Hypercholesterolemia · See more »

Hyperlipidemia

Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood.

New!!: Apolipoprotein E and Hyperlipidemia · See more »

Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

New!!: Apolipoprotein E and Immune system · See more »

Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

New!!: Apolipoprotein E and Inflammation · See more »

Intermediate-density lipoprotein

Intermediate-density lipoproteins (IDLs) belong to the lipoprotein particle family and are formed from the degradation of very low-density lipoproteins as well as high-density lipoproteins.

New!!: Apolipoprotein E and Intermediate-density lipoprotein · See more »

Intron

An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.

New!!: Apolipoprotein E and Intron · See more »

Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

New!!: Apolipoprotein E and Kidney · See more »

Knockout mouse

A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.

New!!: Apolipoprotein E and Knockout mouse · See more »

LDL receptor

The Low-Density Lipoprotein (LDL) Receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL.

New!!: Apolipoprotein E and LDL receptor · See more »

Lipid

In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.

New!!: Apolipoprotein E and Lipid · See more »

Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

New!!: Apolipoprotein E and Liver · See more »

Liver X receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR.

New!!: Apolipoprotein E and Liver X receptor · See more »

Low-density lipoprotein

Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein which transport all fat molecules around the body in the extracellular water.

New!!: Apolipoprotein E and Low-density lipoprotein · See more »

Low-density lipoprotein receptor gene family

The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types.

New!!: Apolipoprotein E and Low-density lipoprotein receptor gene family · See more »

Lymphatic system

The lymphatic system is part of the vascular system and an important part of the immune system, comprising a network of lymphatic vessels that carry a clear fluid called lymph (from Latin, lympha meaning "water") directionally towards the heart.

New!!: Apolipoprotein E and Lymphatic system · See more »

Macrophage

Macrophages (big eaters, from Greek μακρός (makrós).

New!!: Apolipoprotein E and Macrophage · See more »

Malaria

Malaria is a mosquito-borne infectious disease affecting humans and other animals caused by parasitic protozoans (a group of single-celled microorganisms) belonging to the Plasmodium type.

New!!: Apolipoprotein E and Malaria · See more »

Melanocyte

Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), the inner ear, vaginal epithelium, meninges, bones, and heart.

New!!: Apolipoprotein E and Melanocyte · See more »

Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

New!!: Apolipoprotein E and Metabolism · See more »

Microglia

Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord.

New!!: Apolipoprotein E and Microglia · See more »

Microphthalmia-associated transcription factor

Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene.

New!!: Apolipoprotein E and Microphthalmia-associated transcription factor · See more »

Multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

New!!: Apolipoprotein E and Multiple sclerosis · See more »

Natural killer T cell

Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells.

New!!: Apolipoprotein E and Natural killer T cell · See more »

Neurite

A neurite or neuronal process refers to any projection from the cell body of a neuron.

New!!: Apolipoprotein E and Neurite · See more »

Neuron

A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

New!!: Apolipoprotein E and Neuron · See more »

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.

New!!: Apolipoprotein E and Nuclear receptor · See more »

Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

New!!: Apolipoprotein E and Parkinson's disease · See more »

Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

New!!: Apolipoprotein E and Peptide · See more »

Peroxisome proliferator-activated receptor

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes.

New!!: Apolipoprotein E and Peroxisome proliferator-activated receptor · See more »

Polymorphism (biology)

Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

New!!: Apolipoprotein E and Polymorphism (biology) · See more »

Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

New!!: Apolipoprotein E and Protein dimer · See more »

Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

New!!: Apolipoprotein E and Protein isoform · See more »

Proteolysis

Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.

New!!: Apolipoprotein E and Proteolysis · See more »

Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

New!!: Apolipoprotein E and Receptor (biochemistry) · See more »

Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

New!!: Apolipoprotein E and Redox · See more »

Retinoid X receptor

The retinoid X receptor (RXR) is a type of nuclear receptor that is activated by 9-cis retinoic acid, which is discussed controversially to be of endogenous relevance, and 9-cis-13,14-dihydro-retinoic acid, which is likely to be the major endogenous mammalian RXR-selective agonist.

New!!: Apolipoprotein E and Retinoid X receptor · See more »

Sleep apnea

Sleep apnea, also spelled sleep apnoea, is a sleep disorder characterized by pauses in breathing or periods of shallow breathing during sleep.

New!!: Apolipoprotein E and Sleep apnea · See more »

Spleen

The spleen is an organ found in virtually all vertebrates.

New!!: Apolipoprotein E and Spleen · See more »

T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

New!!: Apolipoprotein E and T cell · See more »

Telomere

A telomere is a region of repetitive nucleotide sequences at each end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes.

New!!: Apolipoprotein E and Telomere · See more »

Traumatic brain injury

Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force injures the brain.

New!!: Apolipoprotein E and Traumatic brain injury · See more »

Triglyceride

A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from tri- and glyceride).

New!!: Apolipoprotein E and Triglyceride · See more »

Very low-density lipoprotein

Very-low-density lipoprotein (VLDL), density relative to extracellular water, is a type of lipoprotein made by the liver.

New!!: Apolipoprotein E and Very low-density lipoprotein · See more »

Vitamin

A vitamin is an organic molecule (or related set of molecules) which is an essential micronutrient - that is, a substance which an organism needs in small quantities for the proper functioning of its metabolism - but cannot synthesize it (either at all, or in sufficient quantities), and therefore it must be obtained through the diet.

New!!: Apolipoprotein E and Vitamin · See more »

Vitamin D

Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects.

New!!: Apolipoprotein E and Vitamin D · See more »

Redirects here:

APOE (gene), APOE gene, APOE2, APOE3, APOE4, Apo E, ApoE, ApoE-ε2, ApoE-ε3, ApoE-ε4, ApoE2, ApoE3, ApoE4, Apoe-4, Apoliprotein E, Rs429358.

References

[1] https://en.wikipedia.org/wiki/Apolipoprotein_E

OutgoingIncoming
Hey! We are on Facebook now! »