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Pitolisant

Index Pitolisant

Pitolisant, also known as tiprolisant, and sold under the brand name Wakix, is a potent and selective inverse agonist of the histamine H3 receptor (Ki. [1]

12 relations: Binding selectivity, Clinical trial, Histamine, Histamine H3 receptor, Histamine receptor, Hydrochloride, Hypersomnia, Inverse agonist, Narcolepsy, Oral administration, Oxalate, Potency (pharmacology).

Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Histamine

Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.

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Histamine H3 receptor

Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.

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Histamine receptor

The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.

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Hydrochloride

In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).

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Hypersomnia

Hypersomnia, or hypersomnolence, is a neurological disorder of excessive time spent sleeping or excessive sleepiness.

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Inverse agonist

In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.

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Narcolepsy

Narcolepsy is a long-term neurological disorder that involves a decreased ability to regulate sleep-wake cycles.

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Oral administration

| name.

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Oxalate

Oxalate (IUPAC: ethanedioate) is the dianion with the formula, also written.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Redirects here:

BF 2649, BF-2649, BF2 649, BF2-649, BF2.649, BF2649, C17H26ClNO, Pitolisant hydrochloride, Pitolisant oxalate, Tiprolisant, Tiprolisant hydrochloride, Tiprolisant oxalate, Wakix.

References

[1] https://en.wikipedia.org/wiki/Pitolisant

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