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Irosustat

Index Irosustat

Irosustat (developmental code names STX-64, 667-coumate, BN-83495; also known as oristusane) is an orally active, irreversible, nonsteroidal inhibitor of steroid sulfatase (STS) which was under development by Ipsen for the treatment of hormone-sensitive cancers such as breast cancer, prostate cancer, and endometrial cancer but was never marketed. [1]

23 relations: Androgen, Androstenediol, Androstenedione, Breast, Breast cancer, Clinical trial, Dehydroepiandrosterone sulfate, Endometrial cancer, Enzyme inhibitor, Estrogen, Estrone, Estrone sulfate, Hormone-sensitive cancer, Ipsen, Neoplasm, Nonsteroidal, Oral administration, Prostate cancer, Steroid, Steroid sulfatase, Sulfate, Testosterone, Tissue (biology).

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

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Androstenediol

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA).

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Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA).

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Breast

The breast is one of two prominences located on the upper ventral region of the torso of primates.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex.

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Endometrial cancer

Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Estrogen

Estrogen, or oestrogen, is the primary female sex hormone.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone.

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Estrone sulfate

Estrone sulfate (E1S), or estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate.

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Hormone-sensitive cancer

A hormone-sensitive cancer, or hormone-dependent cancer, is a type of cancer that is dependent on a hormone for growth and/or survival.

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Ipsen

Ipsen is a French pharmaceutical company headquartered in Paris, France.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Nonsteroidal

Nonsteroidal is a term which is used to describe a compound that is not a steroid.

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Oral administration

| name.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Steroid

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Steroid sulfatase

Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids.

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Sulfate

The sulfate or sulphate (see spelling differences) ion is a polyatomic anion with the empirical formula.

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Testosterone

Testosterone is the primary male sex hormone and an anabolic steroid.

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Tissue (biology)

In biology, tissue is a cellular organizational level between cells and a complete organ.

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Redirects here:

667 Coumate, 667 coumate, 667-Coumate, 667-coumate, BN 83,495, BN 83495, BN-83,495, BN-83495, BN83495, Oristusane, STX 64, STX 64PC, STX-64, STX-64PC, STX64, STX64PC.

References

[1] https://en.wikipedia.org/wiki/Irosustat

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