Get it on Google Play
New! Download Unionpedia on your Android™ device!
Faster access than browser!


Index BRCA1

BRCA1 and BRCA1 are a human gene and its protein product, respectively. [1]

157 relations: ABL (gene), Acetaldehyde, AKT1, Alpha helix, Androgen receptor, Ashkenazi Jews, Association for Molecular Pathology v. Myriad Genetics, Inc., Ataxia telangiectasia and Rad3 related, ATF1, ATM serine/threonine kinase, Aurora A kinase, BACH1, Bangladesh Rehabilitation Centre for Trauma Victims, BARD1, Base pair, Beta sheet, Biological patent, BRCA mutation, BRCA1, BRCA2, BRCC3, BRCT domain, BRE (gene), Breast, Breast cancer, Breast cancer classification, BRIP1, C-jun, C-terminus, Cancer, Caretaker gene, Cell cycle, CHEK2, Chelation, Chromosome, Chromosome 17, CLSPN, Cofactor of BRCA1, Comparative genomic hybridization, CREB-binding protein, CSNK2B, CSTF2, Cyclin-dependent kinase 2, Cysteine, DNA, DNA methylation, DNA repair, DNA replication, Dysplasia, ELK4, ..., EP300, Epigenetics, Estrogen receptor alpha, Fallopian tube, FANCA, FANCD2, Fanconi anemia, Federal Court of Australia, FHL2, Formaldehyde, Gene, Gene nomenclature, H2AFX, Hereditary breast–ovarian cancer syndrome, High Court of Australia, Histidine, Histone deacetylase, Homology (biology), Homology directed repair, HUGO Gene Nomenclature Committee, In vitro, In vivo, Invasive lobular carcinoma, JUNB, JunD, LMO4, Mammal, MAP3K3, Mary-Claire King, MED1, MED17, MED21, MED24, Meiosis, Methylation, MicroRNA, Mir-17 microRNA precursor family, Mir-30 microRNA precursor, Missense mutation, MRE11A, MRN complex, MSH2, MSH3, MSH6, Muller's morphs, Multiplex ligation-dependent probe amplification, Mutation, Myc, Myriad Genetics, N-myc-interactor, Negative elongation factor, Nibrin, Non-homologous end joining, NPM1, Nuclear export signal, Nuclear localization sequence, Nuclear receptor coactivator 2, NUFIP1, Ovarian cancer, P53, PALB2, Penetrance, POLR2A, PPP1CA, Progesterone receptor, Promoter (genetics), Prostate cancer, Protein, Protein dimer, Protein–protein interaction, Rad50, RAD51, RBBP4, RBBP7, RBBP8, Real-time polymerase chain reaction, RELA, Retinoblastoma protein, Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, RING finger domain, RNA Helicase A, RNA polymerase II, Sequence homology, Sister chromatids, SMARCA4, SMARCB1, STAT1, Supreme Court of the United States, Synonym, Tandem repeat, The Guardian, The New York Times, The Sydney Morning Herald, Three prime untranslated region, Transcriptional regulation, Triple-negative breast cancer, Tumor suppressor, UBE2D1, Ubiquitin, University of California, Berkeley, USF2, Valosin-containing protein, XIST, Zinc finger, ZNF350, 60S ribosomal protein L31. Expand index (107 more) »

ABL (gene)

Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.

New!!: BRCA1 and ABL (gene) · See more »


Acetaldehyde (systematic name ethanal) is an organic chemical compound with the formula CH3CHO, sometimes abbreviated by chemists as MeCHO (Me.

New!!: BRCA1 and Acetaldehyde · See more »


RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene.

New!!: BRCA1 and AKT1 · See more »

Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

New!!: BRCA1 and Alpha helix · See more »

Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

New!!: BRCA1 and Androgen receptor · See more »

Ashkenazi Jews

Ashkenazi Jews, also known as Ashkenazic Jews or simply Ashkenazim (אַשְׁכְּנַזִּים, Ashkenazi Hebrew pronunciation:, singular:, Modern Hebrew:; also), are a Jewish diaspora population who coalesced in the Holy Roman Empire around the end of the first millennium.

New!!: BRCA1 and Ashkenazi Jews · See more »

Association for Molecular Pathology v. Myriad Genetics, Inc.

Association for Molecular Pathology v. Myriad Genetics, Inc., 569 U.S. 576 (2013),.

New!!: BRCA1 and Association for Molecular Pathology v. Myriad Genetics, Inc. · See more »

Ataxia telangiectasia and Rad3 related

Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene.

New!!: BRCA1 and Ataxia telangiectasia and Rad3 related · See more »


Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

New!!: BRCA1 and ATF1 · See more »

ATM serine/threonine kinase

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks.

New!!: BRCA1 and ATM serine/threonine kinase · See more »

Aurora A kinase

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.

New!!: BRCA1 and Aurora A kinase · See more »


Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

New!!: BRCA1 and BACH1 · See more »

Bangladesh Rehabilitation Centre for Trauma Victims

Bangladesh Rehabilitation Centre for Trauma Victims (BRCT; বিআরসিটি) is a Bangladeshi NGO, working in the area of rehabilitation of trauma victims.

New!!: BRCA1 and Bangladesh Rehabilitation Centre for Trauma Victims · See more »


BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.

New!!: BRCA1 and BARD1 · See more »

Base pair

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.

New!!: BRCA1 and Base pair · See more »

Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

New!!: BRCA1 and Beta sheet · See more »

Biological patent

A biological patent is a patent on an invention in the field of biology that by law allows the patent holder to exclude others from making, using, selling, or importing the protected invention for a limited period of time.

New!!: BRCA1 and Biological patent · See more »

BRCA mutation

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes.

New!!: BRCA1 and BRCA mutation · See more »


BRCA1 and BRCA1 are a human gene and its protein product, respectively.

New!!: BRCA1 and BRCA1 · See more »


BRCA2 and BRCA2 are a human gene and its protein product, respectively.

New!!: BRCA1 and BRCA2 · See more »


Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

New!!: BRCA1 and BRCC3 · See more »

BRCT domain

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.

New!!: BRCA1 and BRCT domain · See more »

BRE (gene)

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.

New!!: BRCA1 and BRE (gene) · See more »


The breast is one of two prominences located on the upper ventral region of the torso of primates.

New!!: BRCA1 and Breast · See more »

Breast cancer

Breast cancer is cancer that develops from breast tissue.

New!!: BRCA1 and Breast cancer · See more »

Breast cancer classification

Breast cancer classification divides breast cancer into categories according to different schemes criteria and serving a different purpose.

New!!: BRCA1 and Breast cancer classification · See more »


Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene.

New!!: BRCA1 and BRIP1 · See more »


c-Jun is a protein that in humans is encoded by the JUN gene.

New!!: BRCA1 and C-jun · See more »


The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

New!!: BRCA1 and C-terminus · See more »


Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

New!!: BRCA1 and Cancer · See more »

Caretaker gene

Changes in the genome that allow uncontrolled cell proliferation or cell immortality are responsible for cancer.

New!!: BRCA1 and Caretaker gene · See more »

Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

New!!: BRCA1 and Cell cycle · See more »


CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase.

New!!: BRCA1 and CHEK2 · See more »


Chelation is a type of bonding of ions and molecules to metal ions.

New!!: BRCA1 and Chelation · See more »


A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.

New!!: BRCA1 and Chromosome · See more »

Chromosome 17

Chromosome 17 is one of the 23 pairs of chromosomes in humans.

New!!: BRCA1 and Chromosome 17 · See more »


Claspin is a protein that in humans is encoded by the CLSPN gene.

New!!: BRCA1 and CLSPN · See more »

Cofactor of BRCA1

Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B.

New!!: BRCA1 and Cofactor of BRCA1 · See more »

Comparative genomic hybridization

Comparative genomic hybridization is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells.

New!!: BRCA1 and Comparative genomic hybridization · See more »

CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.

New!!: BRCA1 and CREB-binding protein · See more »


Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene.

New!!: BRCA1 and CSNK2B · See more »


Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.

New!!: BRCA1 and CSTF2 · See more »

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, is an enzyme that in humans is encoded by the CDK2 gene.

New!!: BRCA1 and Cyclin-dependent kinase 2 · See more »


Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

New!!: BRCA1 and Cysteine · See more »


Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

New!!: BRCA1 and DNA · See more »

DNA methylation

DNA methylation is a process by which methyl groups are added to the DNA molecule.

New!!: BRCA1 and DNA methylation · See more »

DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

New!!: BRCA1 and DNA repair · See more »

DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

New!!: BRCA1 and DNA replication · See more »


Dysplasia (from Ancient Greek δυσ- dys-, "bad" or "difficult" and πλάσις plasis, "formation") is a term used in pathology to refer to an abnormality of development or an epithelial anomaly of growth and differentiation (epithelial dysplasia).

New!!: BRCA1 and Dysplasia · See more »


ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

New!!: BRCA1 and ELK4 · See more »


Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A.

New!!: BRCA1 and EP300 · See more »


Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

New!!: BRCA1 and Epigenetics · See more »

Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.

New!!: BRCA1 and Estrogen receptor alpha · See more »

Fallopian tube

The Fallopian tubes, also known as uterine tubes or salpinges (singular salpinx), are two very fine tubes lined with ciliated epithelia, leading from the ovaries of female mammals into the uterus, via the uterotubal junction.

New!!: BRCA1 and Fallopian tube · See more »


Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene.

New!!: BRCA1 and FANCA · See more »


Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene.

New!!: BRCA1 and FANCD2 · See more »

Fanconi anemia

Fanconi anaemia (FA) is a rare genetic disease resulting in impaired response to DNA damage.

New!!: BRCA1 and Fanconi anemia · See more »

Federal Court of Australia

The Federal Court of Australia is an Australian superior court of record which has jurisdiction to deal with most civil disputes governed by federal law (with the exception of family law matters), along with some summary (less serious) criminal matters.

New!!: BRCA1 and Federal Court of Australia · See more »


Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene.

New!!: BRCA1 and FHL2 · See more »


No description.

New!!: BRCA1 and Formaldehyde · See more »


In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: BRCA1 and Gene · See more »

Gene nomenclature

Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms.

New!!: BRCA1 and Gene nomenclature · See more »


H2AFX (H2A histone family, member X) is one of several genes coding for histone H2A.

New!!: BRCA1 and H2AFX · See more »

Hereditary breast–ovarian cancer syndrome

Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual had both, or several individuals in the pedigree had one or the other disease).

New!!: BRCA1 and Hereditary breast–ovarian cancer syndrome · See more »

High Court of Australia

The High Court of Australia is the supreme court in the Australian court hierarchy and the final court of appeal in Australia.

New!!: BRCA1 and High Court of Australia · See more »


Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins.

New!!: BRCA1 and Histidine · See more »

Histone deacetylase

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O.

New!!: BRCA1 and Histone deacetylase · See more »

Homology (biology)

In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.

New!!: BRCA1 and Homology (biology) · See more »

Homology directed repair

Homology directed repair (HDR) is a mechanism in cells to repair double strand DNA lesions.

New!!: BRCA1 and Homology directed repair · See more »

HUGO Gene Nomenclature Committee

The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature.

New!!: BRCA1 and HUGO Gene Nomenclature Committee · See more »

In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

New!!: BRCA1 and In vitro · See more »

In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

New!!: BRCA1 and In vivo · See more »

Invasive lobular carcinoma

Invasive lobular carcinoma accounts for 5-10% of invasive breast cancer.

New!!: BRCA1 and Invasive lobular carcinoma · See more »


Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene.

New!!: BRCA1 and JUNB · See more »


Transcription factor JunD is a protein that in humans is encoded by the JUND gene.

New!!: BRCA1 and JunD · See more »


LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.

New!!: BRCA1 and LMO4 · See more »


Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

New!!: BRCA1 and Mammal · See more »


Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3).

New!!: BRCA1 and MAP3K3 · See more »

Mary-Claire King

Mary-Claire King (born February 27, 1946) is an American human geneticist.

New!!: BRCA1 and Mary-Claire King · See more »


Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene.

New!!: BRCA1 and MED1 · See more »


Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.

New!!: BRCA1 and MED17 · See more »


Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.

New!!: BRCA1 and MED21 · See more »


Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.

New!!: BRCA1 and MED24 · See more »


Meiosis (from Greek μείωσις, meiosis, which means lessening) is a specialized type of cell division that reduces the chromosome number by half, creating four haploid cells, each genetically distinct from the parent cell that gave rise to them.

New!!: BRCA1 and Meiosis · See more »


In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.

New!!: BRCA1 and Methylation · See more »


A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.

New!!: BRCA1 and MicroRNA · See more »

Mir-17 microRNA precursor family

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression.

New!!: BRCA1 and Mir-17 microRNA precursor family · See more »

Mir-30 microRNA precursor

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression.

New!!: BRCA1 and Mir-30 microRNA precursor · See more »

Missense mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

New!!: BRCA1 and Missense mutation · See more »


Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.

New!!: BRCA1 and MRE11A · See more »

MRN complex

The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast).

New!!: BRCA1 and MRN complex · See more »


DNA mismatch repair protein Msh2 also known as MutS protein homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.

New!!: BRCA1 and MSH2 · See more »


DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system.

New!!: BRCA1 and MSH3 · See more »


MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae.

New!!: BRCA1 and MSH6 · See more »

Muller's morphs

Hermann J. Muller (1890–1967), who was a 1946 Nobel Prize winner, coined the terms amorph, hypomorph, hypermorph, antimorph and neomorph to classify mutations based on their behaviour in various genetic situations, as well as gene interaction between themselves.

New!!: BRCA1 and Muller's morphs · See more »

Multiplex ligation-dependent probe amplification

Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair.

New!!: BRCA1 and Multiplex ligation-dependent probe amplification · See more »


In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

New!!: BRCA1 and Mutation · See more »


Myc is a family of regulator genes and proto-oncogenes that code for transcription factors.

New!!: BRCA1 and Myc · See more »

Myriad Genetics

Myriad Genetics, Inc. is an American molecular diagnostic company based in Salt Lake City, Utah, United States.

New!!: BRCA1 and Myriad Genetics · See more »


N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

New!!: BRCA1 and N-myc-interactor · See more »

Negative elongation factor

In molecular biology, NELF (negative elongation factor) is a four-subunit protein (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription by RNA polymerase II (Pol II) by pausing about 20-60 nucleotides downstream from the transcription start site (TSS).

New!!: BRCA1 and Negative elongation factor · See more »


Nibrin, also known as NBN or NBS1, is a protein which in humans is encoded by the NBN gene.

New!!: BRCA1 and Nibrin · See more »

Non-homologous end joining

Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA.

New!!: BRCA1 and Non-homologous end joining · See more »


Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.

New!!: BRCA1 and NPM1 · See more »

Nuclear export signal

A nuclear export signal (NES) is a short amino acid sequence of 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex using nuclear transport.

New!!: BRCA1 and Nuclear export signal · See more »

Nuclear localization sequence

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.

New!!: BRCA1 and Nuclear localization sequence · See more »

Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene.

New!!: BRCA1 and Nuclear receptor coactivator 2 · See more »


Nuclear fragile X mental retardation-interacting protein 1 is a protein that in humans is encoded by the NUFIP1 gene.

New!!: BRCA1 and NUFIP1 · See more »

Ovarian cancer

Ovarian cancer is a cancer that forms in or on an ovary.

New!!: BRCA1 and Ovarian cancer · See more »


Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

New!!: BRCA1 and P53 · See more »


Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

New!!: BRCA1 and PALB2 · See more »


Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype).

New!!: BRCA1 and Penetrance · See more »


DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the POLR2A gene.

New!!: BRCA1 and POLR2A · See more »


Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

New!!: BRCA1 and PPP1CA · See more »

Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

New!!: BRCA1 and Progesterone receptor · See more »

Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.

New!!: BRCA1 and Promoter (genetics) · See more »

Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

New!!: BRCA1 and Prostate cancer · See more »


Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

New!!: BRCA1 and Protein · See more »

Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

New!!: BRCA1 and Protein dimer · See more »

Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

New!!: BRCA1 and Protein–protein interaction · See more »


DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene.

New!!: BRCA1 and Rad50 · See more »


RAD51 is a eukaryotic gene.

New!!: BRCA1 and RAD51 · See more »


Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.

New!!: BRCA1 and RBBP4 · See more »


Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

New!!: BRCA1 and RBBP7 · See more »


Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

New!!: BRCA1 and RBBP8 · See more »

Real-time polymerase chain reaction

A real-time polymerase chain reaction (Real-Time PCR), also known as quantitative polymerase chain reaction (qPCR), is a laboratory technique of molecular biology based on the polymerase chain reaction (PCR).

New!!: BRCA1 and Real-time polymerase chain reaction · See more »


Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

New!!: BRCA1 and RELA · See more »

Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.

New!!: BRCA1 and Retinoblastoma protein · See more »

Retinoblastoma-like protein 1

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.

New!!: BRCA1 and Retinoblastoma-like protein 1 · See more »

Retinoblastoma-like protein 2

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.

New!!: BRCA1 and Retinoblastoma-like protein 2 · See more »

RING finger domain

In molecular biology, a RING (Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively).

New!!: BRCA1 and RING finger domain · See more »

RNA Helicase A

ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene.

New!!: BRCA1 and RNA Helicase A · See more »

RNA polymerase II

RNA polymerase II (RNAP II and Pol II) is a multiprotein complex.

New!!: BRCA1 and RNA polymerase II · See more »

Sequence homology

Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.

New!!: BRCA1 and Sequence homology · See more »

Sister chromatids

A sister chromatid refers to the identical copies (chromatids) formed by the replication of a chromosome, with both copies joined together by a common centromere.

New!!: BRCA1 and Sister chromatids · See more »


Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

New!!: BRCA1 and SMARCA4 · See more »


SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.

New!!: BRCA1 and SMARCB1 · See more »


Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene.

New!!: BRCA1 and STAT1 · See more »

Supreme Court of the United States

The Supreme Court of the United States (sometimes colloquially referred to by the acronym SCOTUS) is the highest federal court of the United States.

New!!: BRCA1 and Supreme Court of the United States · See more »


A synonym is a word or phrase that means exactly or nearly the same as another word or phrase in the same language.

New!!: BRCA1 and Synonym · See more »

Tandem repeat

Tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other.

New!!: BRCA1 and Tandem repeat · See more »

The Guardian

The Guardian is a British daily newspaper.

New!!: BRCA1 and The Guardian · See more »

The New York Times

The New York Times (sometimes abbreviated as The NYT or The Times) is an American newspaper based in New York City with worldwide influence and readership.

New!!: BRCA1 and The New York Times · See more »

The Sydney Morning Herald

The Sydney Morning Herald (SMH) is a daily compact newspaper published by Fairfax Media in Sydney, Australia.

New!!: BRCA1 and The Sydney Morning Herald · See more »

Three prime untranslated region

In molecular genetics, the three prime untranslated region (3'-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon.

New!!: BRCA1 and Three prime untranslated region · See more »

Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.

New!!: BRCA1 and Transcriptional regulation · See more »

Triple-negative breast cancer

Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) and Her2/neu.

New!!: BRCA1 and Triple-negative breast cancer · See more »

Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

New!!: BRCA1 and Tumor suppressor · See more »


Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.

New!!: BRCA1 and UBE2D1 · See more »


Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.

New!!: BRCA1 and Ubiquitin · See more »

University of California, Berkeley

The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public research university in Berkeley, California.

New!!: BRCA1 and University of California, Berkeley · See more »


Upstream stimulatory factor 2 is a protein that in humans just encoded by the USF2 gene.

New!!: BRCA1 and USF2 · See more »

Valosin-containing protein

Transitional endoplasmic reticulum ATPase (TER ATPase) also known as valosin-containing protein (VCP) or CDC48 in S. Cerevisiae is an enzyme that in humans is encoded by the VCP gene.

New!!: BRCA1 and Valosin-containing protein · See more »


Xist (X-inactive specific transcript) is an RNA gene on the X chromosome of the placental mammals that acts as a major effector of the X inactivation process.

New!!: BRCA1 and XIST · See more »

Zinc finger

A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold.

New!!: BRCA1 and Zinc finger · See more »


Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.

New!!: BRCA1 and ZNF350 · See more »

60S ribosomal protein L31

60S ribosomal protein L31 is a protein that in humans is encoded by the RPL31 gene.

New!!: BRCA1 and 60S ribosomal protein L31 · See more »

Redirects here:

BRCA gene, BRCA1 (gene), BRCA1 Cancer, BRCA1 mutation, BRCA1 protein, Brca1, Brca1 protein, Breast cancer 1, Breast cancer gene, Genes, brca1.


[1] https://en.wikipedia.org/wiki/BRCA1

Hey! We are on Facebook now! »