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BRCA2

Index BRCA2

BRCA2 and BRCA2 are a human gene and its protein product, respectively. [1]

113 relations: Alpha helix, Amino acid, Anemia, Antiparallel (biochemistry), Arabidopsis thaliana, Association for Molecular Pathology v. Myriad Genetics, Inc., Bacteria, BARD1, BCCIP, Beta barrel, Beta sheet, Biochemical Society Transactions, Biological patent, Biomolecular structure, Bone marrow suppression, BRCA mutation, BRCA1, BRCA2, BRCC3, BRE (gene), Breast, Breast cancer, Breast Cancer Research, BUB1B, Caenorhabditis elegans, Caretaker gene, Chromosome, Chromosome 13, Corn smut, CREB-binding protein, Current Opinion in Cell Biology, Deletion (genetics), Digital Subscriber System No. 1, DMC1 (gene), DNA, DNA repair, DNA replication, Drosophila melanogaster, EMSY, Eukaryote, Fallopian tube, FANC proteins, FANCD2, FANCG, Fanconi anemia, Federal Court of Australia, Filamin, Gametocyte, Gene, Gene nomenclature, ..., Helix, Helix-turn-helix, Hereditary breast–ovarian cancer syndrome, HMG20B, Homeobox, Homologous recombination, Homology (biology), HUGO Gene Nomenclature Committee, Human genome, Hydrogen bond, Hydrophobe, Institute of Cancer Research, Leukemia, Locus (genetics), Mammal, Medulloblastoma, Meiosis, Messenger RNA, Michael Stratton, MicroRNA, Microscopy Research and Technique, Molecular binding, Mothers against decapentaplegic homolog 3, MRX complex, MYB (gene), Myriad Genetics, Neurogenesis, Oncogene (journal), Oncology Reports, Ovarian cancer, P53, Pakistanis, PALB2, Pancreatic cancer, PCAF, Penetrance, PLK1, Proceedings of the National Academy of Sciences of the United States of America, Prostate cancer, Protein, Protein domain, Protein–protein interaction, RAD51, RAD51L1, RAD51L3, Recombinase, Replication protein A1, Revue de Médecine Interne, Science (journal), SHFM1, Side chain, Supreme Court of the United States, Synaptonemal complex, Synonym, Tandem repeat, The Sydney Morning Herald, Transcription factor, Trends (journals), Tumor suppressor, University of Pennsylvania, Van der Waals force, Wellcome Sanger Institute, XRCC2. Expand index (63 more) »

Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Anemia

Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.

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Antiparallel (biochemistry)

In biochemistry, two biopolymers are antiparallel if they run parallel to each other but with opposite alignments.

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Arabidopsis thaliana

Arabidopsis thaliana, the thale cress, mouse-ear cress or arabidopsis, is a small flowering plant native to Eurasia and Africa.

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Association for Molecular Pathology v. Myriad Genetics, Inc.

Association for Molecular Pathology v. Myriad Genetics, Inc., 569 U.S. 576 (2013),.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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BARD1

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.

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BCCIP

BRCA2 and CDKN1A-interacting protein is a protein that in humans is encoded by the BCCIP gene.

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Beta barrel

A beta barrel is a beta-sheet that twists and coils to form a closed structure in which the first strand is hydrogen bonded to the last.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Biochemical Society Transactions

Biochemical Society Transactions is a bimonthly peer-reviewed scientific journal which publishes the transactions of the annual conference and focused meetings of the Biochemical Society, together with independent meetings supported by the society.

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Biological patent

A biological patent is a patent on an invention in the field of biology that by law allows the patent holder to exclude others from making, using, selling, or importing the protected invention for a limited period of time.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

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Bone marrow suppression

Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes).

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BRCA mutation

A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes.

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BRCA1

BRCA1 and BRCA1 are a human gene and its protein product, respectively.

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BRCA2

BRCA2 and BRCA2 are a human gene and its protein product, respectively.

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BRCC3

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

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BRE (gene)

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.

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Breast

The breast is one of two prominences located on the upper ventral region of the torso of primates.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Breast Cancer Research

Breast Cancer Research is a bimonthly peer-reviewed medical journal covering research into breast cancer.

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BUB1B

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.

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Caenorhabditis elegans

Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.

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Caretaker gene

Changes in the genome that allow uncontrolled cell proliferation or cell immortality are responsible for cancer.

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Chromosome

A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.

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Chromosome 13

Chromosome 13 is one of the 23 pairs of chromosomes in humans.

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Corn smut

Corn smut is a plant disease caused by the pathogenic fungus Ustilago maydis that causes smut on maize and teosinte.

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CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.

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Current Opinion in Cell Biology

Current Opinion in Cell Biology is a bimonthly peer-reviewed scientific journal published by Elsevier covering all aspects of cell biology including genetics, cell communication, and metabolism.

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Deletion (genetics)

In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA replication.

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Digital Subscriber System No. 1

Digital Subscriber Signalling System No. 1 (DSS1) is a digital signalling protocol (D channel protocol) used for the ISDN.

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DMC1 (gene)

Meiotic recombination protein DMC1/LIM15 homolog is a protein that in humans is encoded by the DMC1 gene.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

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Drosophila melanogaster

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.

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EMSY

EMSY is a protein that in humans is encoded by the EMSY gene.

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Eukaryote

Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).

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Fallopian tube

The Fallopian tubes, also known as uterine tubes or salpinges (singular salpinx), are two very fine tubes lined with ciliated epithelia, leading from the ovaries of female mammals into the uterus, via the uterotubal junction.

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FANC proteins

FANC proteins are a group of proteins associated with Fanconi anemia.

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FANCD2

Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene.

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FANCG

Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene.

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Fanconi anemia

Fanconi anaemia (FA) is a rare genetic disease resulting in impaired response to DNA damage.

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Federal Court of Australia

The Federal Court of Australia is an Australian superior court of record which has jurisdiction to deal with most civil disputes governed by federal law (with the exception of family law matters), along with some summary (less serious) criminal matters.

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Filamin

Filamins are a class of proteins that hold two actin filaments at large angles.

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Gametocyte

A gametocyte is a eukaryotic germ cell that divides by mitosis into other gametocytes or by meiosis into gametids during gametogenesis.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene nomenclature

Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms.

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Helix

A helix, plural helixes or helices, is a type of smooth space curve, i.e. a curve in three-dimensional space.

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Helix-turn-helix

In proteins, the helix-turn-helix (HTH) is a major structural motif capable of binding DNA.

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Hereditary breast–ovarian cancer syndrome

Hereditary breast–ovarian cancer syndromes (HBOC) are cancer syndromes that produce higher than normal levels of breast cancer and ovarian cancer in genetically related families (either one individual had both, or several individuals in the pedigree had one or the other disease).

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HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.

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Homeobox

A homeobox is a DNA sequence, around 180 base pairs long, found within genes that are involved in the regulation of patterns of anatomical development (morphogenesis) in animals, fungi and plants.

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Homologous recombination

Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA.

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Homology (biology)

In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.

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HUGO Gene Nomenclature Committee

The HUGO Gene Nomenclature Committee (HGNC) is a committee of the Human Genome Organisation (HUGO) that sets the standards for human gene nomenclature.

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Human genome

The human genome is the complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Hydrophobe

In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.

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Institute of Cancer Research

The Institute of Cancer Research (the ICR) is a public research institute and a constituent college of the University of London in London, United Kingdom, specialising in oncology.

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Leukemia

Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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Medulloblastoma

Medulloblastoma is the most common type of pediatric malignant primary brain tumor (cancer), originating in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa.

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Meiosis

Meiosis (from Greek μείωσις, meiosis, which means lessening) is a specialized type of cell division that reduces the chromosome number by half, creating four haploid cells, each genetically distinct from the parent cell that gave rise to them.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Michael Stratton

Sir Michael Rudolf Stratton, (born 22 June 1957) is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute.

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MicroRNA

A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.

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Microscopy Research and Technique

Microscopy Research and Technique is a peer-reviewed scientific journal covering all areas of advanced microscopy in the biological, clinical, chemical, and materials science fields.

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Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

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Mothers against decapentaplegic homolog 3

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

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MRX complex

The MRX complex is a heterotrimeric protein complex consisting of Mre11, Rad50, and Xrs2.

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MYB (gene)

Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.

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Myriad Genetics

Myriad Genetics, Inc. is an American molecular diagnostic company based in Salt Lake City, Utah, United States.

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Neurogenesis

Neurogenesis is the process by which nervous system cells, known as neurons, are produced by neural stem cells (NSC)s, and it occurs in all species of animals except the porifera (sponges) and placozoans.

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Oncogene (journal)

Oncogene is a peer-reviewed scientific journal published by the Nature Publishing Group addressing cancer cell genetics and the structure and function of oncogenes.

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Oncology Reports

Oncology Reports is a peer-reviewed medical journal of oncology published monthly by Spandidos Publications.

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Ovarian cancer

Ovarian cancer is a cancer that forms in or on an ovary.

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P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Pakistanis

No description.

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PALB2

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

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Pancreatic cancer

Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.

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PCAF

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

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Penetrance

Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype).

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PLK1

Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America (PNAS) is the official scientific journal of the National Academy of Sciences, published since 1915.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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RAD51

RAD51 is a eukaryotic gene.

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RAD51L1

DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene.

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RAD51L3

DNA repair protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene.

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Recombinase

Recombinases are genetic recombination enzymes.

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Replication protein A1

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

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Revue de Médecine Interne

The Revue de Médecine Interne is a French medical journal that covers research in internal medicine.

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Science (journal)

Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.

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SHFM1

26S proteasome complex subunit DSS1 is a protein that in humans is encoded by the SHFM1 gene.

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Side chain

In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called "main chain" or backbone.

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Supreme Court of the United States

The Supreme Court of the United States (sometimes colloquially referred to by the acronym SCOTUS) is the highest federal court of the United States.

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Synaptonemal complex

The synaptonemal complex (SC) is a protein structure that forms between homologous chromosomes (two pairs of sister chromatids) during meiosis and is thought to mediate chromosome pairing, synapsis, and recombination.

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Synonym

A synonym is a word or phrase that means exactly or nearly the same as another word or phrase in the same language.

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Tandem repeat

Tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other.

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The Sydney Morning Herald

The Sydney Morning Herald (SMH) is a daily compact newspaper published by Fairfax Media in Sydney, Australia.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Trends (journals)

Trends is a series of scientific journals owned by Elsevier that publish review articles in a range of areas of biology.

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Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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University of Pennsylvania

The University of Pennsylvania (commonly known as Penn or UPenn) is a private Ivy League research university located in University City section of West Philadelphia.

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Van der Waals force

In molecular physics, the van der Waals forces, named after Dutch scientist Johannes Diderik van der Waals, are distance-dependent interactions between atoms or molecules.

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Wellcome Sanger Institute

The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.

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XRCC2

DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene.

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Redirects here:

BRCA2 (gene), Brca2, Brca2 protein, FANCD1, Genes, brca2.

References

[1] https://en.wikipedia.org/wiki/BRCA2

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