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37 relations: Alpha helix, Alternative splicing, Apoptosis, Bcl-2, Bcl-xL, BCL2-like 1 (gene), BCL2L10, BCL2L11, BCL2L13, BCL2L14, BCL2L2, BH3 interacting-domain death agonist, BOK (gene), Calcium in biology, Caspase, Cloning, Colicin, Conserved sequence, Cytochrome c, Cytosol, Diablo homolog, Diphtheria toxin, Growth factor, Homology (biology), Hydrophobe, MCL1, Mitochondrial apoptosis-induced channel, Mitochondrial permeability transition pore, Mitochondrion, N-terminus, Nuclear envelope, PH, Protein domain, Protein isoform, Rho family of GTPases, Sequence homology, Transmembrane protein.
Alpha helix
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.
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Bcl-xL
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria.
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BCL2-like 1 (gene)
Bcl-2-like 1 or BCL2L1 is a human gene.
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BCL2L10
Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.
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BCL2L11
Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.
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BCL2L13
BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the BCL2L13 gene on chromosome 22.
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BCL2L14
Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.
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BCL2L2
Bcl-2-like protein 2 is a protein that in humans is encoded by the BCL2L2 gene.
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BH3 interacting-domain death agonist
The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family.
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BOK (gene)
Bok (Bcl-2 related ovarian killer) is a protein-coding gene of the Bcl-2 family that is found in many invertebrates and vertebrates.
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Calcium in biology
Calcium ions (Ca2+) play a vital role in the physiology and biochemistry of organisms and the cell.
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Caspase
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
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Cloning
Cloning is the process of producing genetically identical individuals of an organism either naturally or artificially.
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Colicin
A colicin is a type of bacteriocin produced by and toxic to some strains of Escherichia coli.
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Conserved sequence
In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences) or within a genome (paralogous sequences).
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Cytochrome c
The cytochrome complex, or cyt c is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion.
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Cytosol
The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.
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Diablo homolog
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12.
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Diphtheria toxin
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria.
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Growth factor
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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Hydrophobe
In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.
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MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.
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Mitochondrial apoptosis-induced channel
The mitochondrial apoptosis-induced channel (or MAC), is an early marker of the onset of apoptosis.
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Mitochondrial permeability transition pore
The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke.
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Mitochondrion
The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Nuclear envelope
The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes which surrounds the nucleus, and in eukaryotic cells it encases the genetic material.
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PH
In chemistry, pH is a logarithmic scale used to specify the acidity or basicity of an aqueous solution.
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Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Rho family of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily.
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Sequence homology
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.
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Transmembrane protein
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.
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Apoptosis regulator proteins, Bcl-2 family, BH domain, BH3 domain, BH3-only family.
References
[1] https://en.wikipedia.org/wiki/Bcl-2_family
