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Biliverdin reductase

Index Biliverdin reductase

Biliverdin reductase (BVR) is an enzyme found in all tissues under normal conditions, but especially in reticulo-macrophages of the liver and spleen. [1]

28 relations: Active site, Alpha helix, Beta sheet, Bilirubin, Biliverdin, Biliverdin reductase A, Biliverdin reductase B, Biocatalysis, Biomolecular structure, C-terminus, Carbohydrate metabolism, Cofactor (biochemistry), Diabetes mellitus, Enzyme, Glucuronic acid, Heme, Heme oxygenase, Isozyme, MAPK/ERK pathway, Multiple sclerosis, N-terminus, Nicotinamide adenine dinucleotide phosphate, Organic redox reaction, Pyrrole, Reactive oxygen species, Redox, Rossmann fold, Space-filling model.

Active site

In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.

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Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Bilirubin

Bilirubin is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.

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Biliverdin

Biliverdin is a green tetrapyrrolic bile pigment, and is a product of heme catabolism.

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Biliverdin reductase A

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.

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Biliverdin reductase B

Biliverdin reductase B is a protein that in humans is encoded by the BLVRB gene.

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Biocatalysis

Biocatalysis is catalysis in living (biological) systems.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Carbohydrate metabolism

Carbohydrate metabolism denotes the various biochemical processes responsible for the formation, breakdown, and interconversion of carbohydrates in living organisms.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Diabetes mellitus

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Glucuronic acid

Glucuronic acid (from Greek γλυκύς "sweet" and οὖρον "urine") is a uronic acid that was first isolated from urine (hence the name).

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Heme

Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.

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Heme oxygenase

Heme oxygenase or haem oxygenase (HO) is an enzyme that catalyzes the degradation of heme.

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Isozyme

Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.

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MAPK/ERK pathway

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

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Multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Nicotinamide adenine dinucleotide phosphate

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

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Organic redox reaction

Organic reductions or organic oxidations or organic redox reactions are redox reactions that take place with organic compounds.

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Pyrrole

Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Rossmann fold

The Rossmann fold is a structural motif found in proteins that bind nucleotides, such as enzyme cofactors FAD, NAD+, and NADP+.

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Space-filling model

In chemistry, a space-filling model, also known as a calotte model, is a type of three-dimensional (3D) molecular model where the atoms are represented by spheres whose radii are proportional to the radii of the atoms and whose center-to-center distances are proportional to the distances between the atomic nuclei, all in the same scale.

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Redirects here:

Bilirubin:NAD(P)+ oxidoreductase, EC 1.3.1.24.

References

[1] https://en.wikipedia.org/wiki/Biliverdin_reductase

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