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Binding selectivity

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Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex. [1]

62 relations: Absorbance, Agonist, Analyte, Antagonist, Antibiotics, Biochemistry, Blood transfusion, Calcium, Cascade (chemical engineering), Cell membrane, Chelation, Cimetidine, Concentration, Coordination complex, Copper, Countercurrent exchange, Cytoplasm, Deferasirox, Deferiprone, Deferoxamine, Equilibrium constant, Ethylenediaminetetraacetic acid, Functional selectivity, Gas chromatography, H2 antagonist, Hormone, Hydrogen bond, Ion selective electrode, Iron overload, Kerosene, Lanthanide, Lead, Ligand (biochemistry), Luminescence, Magnesium, Mercury (element), Molecular binding, Monazite, Neurotransmitter, Non-covalent interactions, Oxidation state, Partition coefficient, Penicillamine, Peptic ulcer, Peptide, Periodic table, Potassium, Protein, Quantitative structure–activity relationship, Ranitidine, ..., Retardation factor, Separation process, Siderophore, Stability constants of complexes, Stoichiometry, Thalassemia, Theoretical plate, Thermodynamic activity, Tributyl phosphate, Valinomycin, Van der Waals force, Wilson's disease. Expand index (12 more) »

In chemistry, absorbance or decadic absorbance is the common logarithm of the ratio of incident to transmitted radiant power through a material, and spectral absorbance or spectral decadic absorbance is the common logarithm of the ratio of incident to transmitted spectral radiant power through a material.

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An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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An analyte, or component (in clinical chemistry), is a substance or chemical constituent that is of interest in an analytical procedure.

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An antagonist is a character, group of characters, institution, or concept that stands in or represents opposition against which the protagonist(s) must contend.

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Antibiotics or antibacterials are a type of antimicrobial used in the treatment and prevention of bacterial infection.

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Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms.

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Blood transfusion is generally the process of receiving blood products into one's circulation intravenously.

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Calcium is a chemical element with symbol Ca and atomic number 20.

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In chemical engineering, a cascade is a plant consisting of several similar stages with each processing the output from the previous stage.

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The cell membrane (also known as the plasma membrane or cytoplasmic membrane) is a biological membrane that separates the interior of all cells from the outside environment.

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Chelation describes a particular way that ions and molecules bind metal ions.

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Cimetidine INN is a histamine H2-receptor antagonist that inhibits stomach acid production. It is largely used in the treatment of heartburn and peptic ulcers. It has been marketed by GlaxoSmithKline (which is selling the brand to Prestige Brands) under the trade name Tagamet (sometimes Tagamet HB or Tagamet HB200). Cimetidine was approved in the UK in 1976, and was approved in the US by the Food and Drug Administration for prescriptions starting January 1, 1979.

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In chemistry, concentration is the abundance of a constituent divided by the total volume of a mixture.

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In chemistry, a coordination complex or metal complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents.

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Copper is a chemical element with symbol Cu (from cuprum) and atomic number 29.

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Countercurrent exchange is a mechanism occurring in nature and mimicked in industry and engineering, in which there is a crossover of some property, usually heat or some component, between two flowing bodies flowing in opposite directions to each other.

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The cytoplasm comprises cytosol (the gel-like substance enclosed within the cell membrane) – and the organelles – the cell's internal sub-structures.

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Deferasirox (marketed as Exjade, Desirox, Defrijet, Desifer...) is an oral iron chelator.

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Deferiprone (tradenames include Ferriprox) is a drug that chelates iron and is used to treat thalassaemia major.

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Deferoxamine (also known as desferrioxamine B, desferoxamine B, DFO-B, DFOA, DFB or desferal) is a bacterial siderophore produced by the Actinobacteria Streptomyces pilosus.

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The equilibrium constant of a chemical reaction is the value of the reaction quotient when the reaction has reached equilibrium.

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Ethylenediaminetetraacetic acid, widely abbreviated as EDTA (for other names, see Table), is an aminopolycarboxylic acid and a colourless, water-soluble solid.

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Functional selectivity (or “agonist trafficking”, “biased agonism”, "ligand bias", and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways in one and the same receptor.

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Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition.

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The H2 receptor antagonists (H2RA) are a class of drugs used to block the action of histamine on parietal cells (specifically the histamine H2 receptors) in the stomach, decreasing the production of acid by these cells.

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A hormone (from Greek ὁρμή, "impetus") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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A hydrogen bond is the electrostatic attraction between polar molecules that occurs when a hydrogen (H) atom bound to a highly electronegative atom such as nitrogen (N), oxygen (O) or fluorine (F) experiences attraction to some other nearby highly electronegative atom.

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An ion-selective electrode (ISE), also known as a specific ion electrode (SIE), is a transducer (or sensor) that converts the activity of a specific ion dissolved in a solution into an electrical potential, which can be measured by a voltmeter or pH meter.

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Iron overload, also known as haemochromatosis, indicates accumulation of iron in the body from any cause.

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Kerosene, also known as lamp oil, is a combustible hydrocarbon liquid widely used as a fuel in industry and households.

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The lanthanide or lanthanoid series of chemical elements comprises the fifteen metallic chemical elements with atomic numbers 57 through 71, from lanthanum through lutetium.

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Lead is a chemical element in the carbon group with symbol Pb (from plumbum) and atomic number 82.

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In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Luminescence is emission of light by a substance not resulting from heat; it is thus a form of cold body radiation.

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Magnesium is a chemical element with symbol Mg and atomic number 12.

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Mercury is a chemical element with symbol Hg and atomic number 80.

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Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

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Monazite is a reddish-brown phosphate mineral containing rare earth metals.

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Neurotransmitters are endogenous chemicals that enable neurotransmission.

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A non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule.

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The oxidation state, often called the oxidation number, is an indicator of the degree of oxidation (loss of electrons) of an atom in a chemical compound.

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In the physical sciences, a partition-coefficient (P) or distribution-coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium.

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Penicillamine is a pharmaceutical of the chelator class.

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Peptic ulcer disease (PUD), also known as a peptic ulcer or stomach ulcer, is a break in the lining of the stomach, first part of the small intestine, or occasionally the lower esophagus.

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Peptides (from Gr. πεπτός, "digested", derived from πέσσειν, "to digest") are biologically occurring short chains of amino acid monomers linked by peptide (amide) bonds.

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The periodic table is a tabular arrangement of the chemical elements, ordered by their atomic number (number of protons in the nucleus), electron configurations, and recurring chemical properties.

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Potassium is a chemical element with symbol K (derived from Neo-Latin kalium) and atomic number 19.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering.

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Ranitidine (trade name Zantac) is a histamine H2-receptor antagonist that inhibits stomach acid production.

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In chromatography, the retardation factor (R) is the fraction of an analyte in the mobile phase of a chromatographic system.

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In chemistry and chemical engineering, a separation process, or a separation technique, or simply a separation, is a method to achieve any mass transfer phenomenon that converts a mixture of substances into two or more distinct product mixtures (which may be referred to as fractions), at least one of which is enriched in one or more of the mixture's constituents.

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Siderophores (Greek: "iron carrier") are small, high-affinity iron chelating compounds secreted by microorganisms such as bacteria, fungi and grasses.

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A stability constant (formation constant, binding constant) is an equilibrium constant for the formation of a complex in solution.

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Stoichiometry is the calculation of relative quantities of reactants and products in chemical reactions.

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Thalassemia (British English: thalassaemia) is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin.

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A theoretical plate in many separation processes is a hypothetical zone or stage in which two phases, such as the liquid and vapor phases of a substance, establish an equilibrium with each other.

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In chemical thermodynamics, activity (symbol a) is a measure of the “effective concentration” of a species in a mixture, in the sense that the species' chemical potential depends on the activity of a real solution in the same way that it would depend on concentration for an ideal solution.

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Tributyl phosphate, known commonly as TBP, is an organophosphorus compound with the chemical formula (CH3CH2CH2CH2O)3PO.

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Valinomycin is a dodecadepsipeptide antibiotic.

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In physical chemistry, the van der Waals forces (or van der Waals' interaction), named after Dutch scientist Johannes Diderik van der Waals, is the sum of the attractive or repulsive forces between molecules (or between parts of the same molecule) other than those due to covalent bonds, or the electrostatic interaction of ions with one another, with neutral molecules, or with charged molecules.

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Wilson's disease or hepatolenticular degeneration is an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease.

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Protein selectivity, Receptor selectivity, Selectivity (pharmacology).


[1] https://en.wikipedia.org/wiki/Binding_selectivity

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