Buprenorphine-3-glucuronide

Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. ^[1]

Active metabolite

An active metabolite, or pharmacologically active metabolite is a biologically active metabolite of a xenobiotic substance, such as a drug or environmental chemical.

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Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

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Analgesic

An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.

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Animal locomotion

In ethology, animal locomotion is any of a variety of methods that animals use to move from one place to another.

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The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

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Buprenorphine

Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. Buprenorphine-3-glucuronide and Buprenorphine are Oripavines and Tertiary alcohols.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Morphine-3-glucuronide

Morphine-3-glucuronide is a metabolite of morphine produced by UGT2B7. Buprenorphine-3-glucuronide and morphine-3-glucuronide are analgesic stubs, Glucuronide esters, opioid metabolites and Secondary alcohols.

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Nociceptin receptor

The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene.

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Norbuprenorphine

Norbuprenorphine is a major active metabolite of the opioid modulator buprenorphine. Buprenorphine-3-glucuronide and Norbuprenorphine are human drug metabolites, opioid metabolites and Tertiary alcohols.

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Norbuprenorphine-3-glucuronide

Norbuprenorphine-3-glucuronide (N3G) is a major active metabolite of the opioid modulator buprenorphine. Buprenorphine-3-glucuronide and Norbuprenorphine-3-glucuronide are Glucuronide esters, human drug metabolites, opioid metabolites and Tertiary alcohols.

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Opioid modulator

An opioid modulator (or opioid receptor modulator) is a drug which has mixed agonist and antagonist actions at different opioid receptors and thus cannot clearly be described as either an opioid agonist or antagonist. Buprenorphine-3-glucuronide and opioid modulator are analgesic stubs.

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P-glycoprotein

P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Respiratory rate

The respiratory rate is the rate at which breathing occurs; it is set and controlled by the respiratory center of the brain.

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Sedation

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

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Substrate (chemistry)

In chemistry, the term substrate is highly context-dependent.

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References

[1] https://en.wikipedia.org/wiki/Buprenorphine-3-glucuronide

Also known as C35H49NO10.

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