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35 relations: Adverse drug reaction, Angiotensin II receptor blocker, AstraZeneca, Bioavailability, Carbonate, Cyclohexane, CYP2C9, Death, Discovery and development of angiotensin receptor blockers, Disease, Ester, Esterase, Ethyl group, Feces, Gastrointestinal tract, Generic drug, Heart failure, Hydrochlorothiazide, Hydroxy group, Hypertension, IC50, International nonproprietary name, Kidney, Laboratory rat, Liver, Placebo, Prehypertension, Prodrug, Randomized controlled trial, Renin–angiotensin system, Statistical significance, Takeda Pharmaceutical Company, The New England Journal of Medicine, Thiazide, Trade name.
Adverse drug reaction
An adverse drug reaction (ADR) is an injury caused by taking a medication.
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Angiotensin II receptor blocker
Angiotensin II receptor blockers (ARBs), also known as angiotensin II receptor antagonists, AT1 receptor antagonists or sartans, are a group of pharmaceuticals that modulate the renin–angiotensin system.
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AstraZeneca
AstraZeneca plc is an Anglo–Swedish multinational pharmaceutical and biopharmaceutical company.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Carbonate
In chemistry, a carbonate is a salt of carbonic acid (H2CO3), characterized by the presence of the carbonate ion, a polyatomic ion with the formula of.
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Cyclohexane
Cyclohexane is a cycloalkane with the molecular formula C6H12 (the alkyl is abbreviated Cy).
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CYP2C9
Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.
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Death
Death is the cessation of all biological functions that sustain a living organism.
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Discovery and development of angiotensin receptor blockers
The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure.
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Disease
A disease is any condition which results in the disorder of a structure or function in an organism that is not due to any external injury.
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Ester
In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.
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Esterase
An esterase is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis.
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Ethyl group
In chemistry, an ethyl group is an alkyl substituent derived from ethane (C2H6).
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Gastrointestinal tract
The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.
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Generic drug
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.
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Heart failure
Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.
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Hydrochlorothiazide
Hydrochlorothiazide (HCTZ or HCT) is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up.
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Hydroxy group
A hydroxy or hydroxyl group is the entity with the formula OH.
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Hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Laboratory rat
A laboratory rat or lab rat is a rat of the species Rattus norvegicus (brown rat) which is bred and kept for scientific research.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Placebo
A placebo is a substance or treatment of no intended therapeutic value.
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Prehypertension
Prehypertension, also known as high normal blood pressure, is an American medical classification for cases where a person's blood pressure is elevated above normal, but not to the level considered hypertension (high blood pressure).
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Prodrug
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Randomized controlled trial
A randomized controlled trial (or randomized control trial; RCT) is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment.
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Renin–angiotensin system
The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that regulates blood pressure and fluid balance.
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.
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Takeda Pharmaceutical Company
is the largest pharmaceutical company in Japan and Asia and a top 15 pharmaceutical company in the world.
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The New England Journal of Medicine
The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society.
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Thiazide
Thiazide is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) and edema (such as that caused by heart failure, liver failure, or kidney failure).
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Trade name
A trade name, trading name, or business name is a pseudonym frequently used by companies to operate under a name different from their registered, legal name.
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Redirects here:
ATC code C09CA06, ATCvet code QC09CA06, Adesan, Amias, Atacand, Blopress, C24H20N6O3, Candasartan, Candesartan cilexetil, Candexetil, Ratacand.
References
[1] https://en.wikipedia.org/wiki/Candesartan
