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67 relations: Ageing, Aggression, Agonist, Altanserin, Alzheimer's disease, American Journal of Psychiatry, Amygdala, Autoradiograph, Basal ganglia, Befiradol, Behavioural Brain Research, Binding potential, Biological Psychiatry (journal), Brain, Brain Research, British Journal of Psychiatry, Cerebral cortex, DASB, David E. Nichols, Dopamine receptor D4, Dopaminergic, Dorsolateral prefrontal cortex, Drug, European Journal of Pharmacology, Head-twitch response, Hippocampus, Hyperalgesia, Hypoventilation, Isotopes of carbon, Journal of Cerebral Blood Flow & Metabolism, Journal of Pharmacology and Experimental Therapeutics, Major depressive disorder, Mefway (18F), Neurochemistry International, NeuroImage, Neuropsychopharmacology (journal), Neurotransmitter receptor, Nuclear Medicine and Biology, Opioid, Panic disorder, Parietal lobe, Piperazine, Polymorphism (biology), Positron emission tomography, Psychopharmacology (journal), Radioligand, Radionuclide, Raphe, Raphe nuclei, Receptor antagonist, ..., Robalzotan, Rs6295, Self-transcendence, Serotonin transporter, Sex, Temperament and Character Inventory, Thalamus, The American Journal of Geriatric Psychiatry, The Journal of Neuroscience, The Journal of Nuclear Medicine, Trait theory, Tritium, UH-301, WAY-100135, 5-HT1A receptor, 5-HTTLPR, 8-OH-DPAT. Expand index (17 more) »
Ageing
Ageing or aging (see spelling differences) is the process of becoming older.
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Aggression
Aggression is overt, often harmful, social interaction with the intention of inflicting damage or other unpleasantness upon another individual.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Altanserin
Altanserin is a compound that binds to the 5-HT2A receptor (5-Hydroxytryptamine (serotonin) 2A receptor).
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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American Journal of Psychiatry
The American Journal of Psychiatry is a monthly peer-reviewed medical journal covering all aspects of psychiatry and the official journal of the American Psychiatric Association.
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Amygdala
The amygdala (plural: amygdalae; also corpus amygdaloideum; Latin from Greek, ἀμυγδαλή, amygdalē, 'Almond', 'tonsil') is one of two almond-shaped groups of nuclei located deep and medially within the temporal lobes of the brain in complex vertebrates, including humans.
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Autoradiograph
An autoradiograph is an image on an x-ray film or nuclear emulsion produced by the pattern of decay emissions (e.g., beta particles or gamma rays) from a distribution of a radioactive substance.
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Basal ganglia
The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.
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Befiradol
Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist.
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Behavioural Brain Research
Behavioural Brain Research is a peer-reviewed scientific journal published by Elsevier.
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Binding potential
In pharmacokinetics and receptor-ligand kinetics the binding potential (BP) is a combined measure of the density of "available" neuroreceptors and the affinity of a drug to that neuroreceptor.
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Biological Psychiatry (journal)
Biological Psychiatry is a biweekly, peer-reviewed, scientific journal of psychiatric neuroscience and therapeutics, published by Elsevier since 1985 on behalf of the Society of Biological Psychiatry, of which it is the official journal.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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Brain Research
Brain Research is a peer-reviewed scientific journal focusing on several aspects of neuroscience.
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British Journal of Psychiatry
The British Journal of Psychiatry is a peer-reviewed medical journal published monthly by the Royal College of Psychiatrists containing original research, systematic reviews, commentaries on contentious articles, short reports, a comprehensive book review section, and a correspondence column relating to all aspects of psychiatry.
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Cerebral cortex
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
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DASB
DASB, 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile, is a compound that binds to the serotonin transporter.
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David E. Nichols
David Earl Nichols (born December 23, 1944, Covington, Kentucky) is an American pharmacologist and medicinal chemist.
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Dopamine receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.
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Dopaminergic
Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.
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Dorsolateral prefrontal cortex
The dorsolateral prefrontal cortex (DLPFC or DL-PFC) is an area in the prefrontal cortex of the brain of humans and non-human primates.
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Drug
A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.
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European Journal of Pharmacology
The European Journal of Pharmacology is a peer-reviewed scientific journal in the field of pharmacology.
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Head-twitch response
The head-twitch response (HTR) is a rapid side-to-side head movement that occurs in mice and rats after the serotonin 5-HT2A receptor is activated.
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Hippocampus
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
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Hyperalgesia
Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus, stimuli which would normally not be cause for a pain reaction (ex/ eyes or brain having a painful reaction to daylight).
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Hypoventilation
Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate (hypo meaning "below") to perform needed gas exchange.
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Isotopes of carbon
Carbon (6C) has 15 known isotopes, from 8C to 22C, of which 12C and 13C are stable.
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Journal of Cerebral Blood Flow & Metabolism
The Journal of Cerebral Blood Flow & Metabolism is a monthly peer-reviewed medical journal the official journal of the International Society for Cerebral Blood Flow & Metabolism and publishes peer-reviewed research and review papers.
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Journal of Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and Experimental Therapeutics (a.k.a. JPET) is a peer-reviewed scientific journal covering pharmacology.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Mefway (18F)
Mefway is a serotonin 5-HT1A receptor antagonist used in medical research, usually in the form of mefway (18F) as a positron emission tomography (PET) radiotracer.
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Neurochemistry International
Neurochemistry International is a peer-reviewed scientific journal covering research in neurochemistry, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of central nervous system function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.
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NeuroImage
NeuroImage is a peer-reviewed scientific journal covering research on neuroimaging, including functional neuroimaging and functional human brain mapping.
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Neuropsychopharmacology (journal)
Neuropsychopharmacology is a peer-reviewed scientific journal published by the Nature Publishing Group.
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Neurotransmitter receptor
A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter.
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Nuclear Medicine and Biology
Nuclear Medicine and Biology is a peer-reviewed medical journal published by Elsevier that covers research on all aspects of nuclear medicine, including radiopharmacology, radiopharmacy, and clinical studies of targeted radiotracers.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Panic disorder
Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.
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Parietal lobe
The parietal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The parietal lobe is positioned above the temporal lobe and behind the frontal lobe and central sulcus. The parietal lobe integrates sensory information among various modalities, including spatial sense and navigation (proprioception), the main sensory receptive area for the sense of touch (mechanoreception) in the somatosensory cortex which is just posterior to the central sulcus in the postcentral gyrus, and the dorsal stream of the visual system. The major sensory inputs from the skin (touch, temperature, and pain receptors), relay through the thalamus to the parietal lobe. Several areas of the parietal lobe are important in language processing. The somatosensory cortex can be illustrated as a distorted figure – the homunculus (Latin: "little man"), in which the body parts are rendered according to how much of the somatosensory cortex is devoted to them.Schacter, D. L., Gilbert, D. L. & Wegner, D. M. (2009). Psychology. (2nd ed.). New York (NY): Worth Publishers. The superior parietal lobule and inferior parietal lobule are the primary areas of body or spacial awareness. A lesion commonly in the right superior or inferior parietal lobule leads to hemineglect. The name comes from the parietal bone, which is named from the Latin paries-, meaning "wall".
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Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.
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Polymorphism (biology)
Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.
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Positron emission tomography
Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.
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Psychopharmacology (journal)
Psychopharmacology is a peer-reviewed scientific journal covering psychopharmacology that is published by Springer Science+Business Media.
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Radioligand
A radioligand is a radioactive biochemical substance (in particular, a ligand that is radiolabeled) that is used for diagnosis or for research-oriented study of the receptor systems of the body.
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Radionuclide
A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is an atom that has excess nuclear energy, making it unstable.
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Raphe
Raphe (from Greek ῥαφή, "seam"Liddell, H.G. & Scott, R. (1940). A Greek-English Lexicon. revised and augmented throughout by Sir Henry Stuart Jones. with the assistance of. Roderick McKenzie. Oxford: Clarendon Press.) has several different meanings in science.
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Raphe nuclei
The raphe nuclei (ῥαφή "seam"Liddell, H.G. & Scott, R. (1940). A Greek-English Lexicon. revised and augmented throughout by Sir Henry Stuart Jones. with the assistance of. Roderick McKenzie. Oxford: Clarendon Press.) are a moderate-size cluster of nuclei found in the brain stem.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Robalzotan
Robalzotan (NAD-299, AZD-7371) is a selective antagonist at the 5-HT1A receptor.
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Rs6295
rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene.
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Self-transcendence
Self-transcendence is a personality trait associated with experiencing spiritual ideas such as considering oneself an integral part of the universe.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Sex
Organisms of many species are specialized into male and female varieties, each known as a sex. Sexual reproduction involves the combining and mixing of genetic traits: specialized cells known as gametes combine to form offspring that inherit traits from each parent.
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Temperament and Character Inventory
The Temperament and Character Inventory (TCI) is an inventory for personality traits devised by Cloninger et al.
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Thalamus
The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.
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The American Journal of Geriatric Psychiatry
The American Journal of Geriatric Psychiatry is a quarterly peer-reviewed medical journal covering geriatric psychiatry.
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The Journal of Neuroscience
The Journal of Neuroscience is a weekly peer-reviewed scientific journal published by the Society for Neuroscience.
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The Journal of Nuclear Medicine
The Journal of Nuclear Medicine is a monthly peer-reviewed medical journal published by Society of Nuclear Medicine and Molecular Imaging that covers research on all aspects of nuclear medicine, including molecular imaging.
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Trait theory
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.
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Tritium
Tritium (or; symbol or, also known as hydrogen-3) is a radioactive isotope of hydrogen.
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UH-301
UH-301 is a drug and research chemical widely used in scientific studies.
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WAY-100135
WAY-100135 is a serotonergic drug of the phenylpiperazine family which is used in scientific research.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HTTLPR
5-HTTLPR (serotonin-transporter-linked polymorphic region) is a degenerate repeat polymorphic region in SLC6A4, the gene that codes for the serotonin transporter.
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8-OH-DPAT
8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor.
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References
[1] https://en.wikipedia.org/wiki/WAY-100635
