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Azacosterol

Index Azacosterol

Azacosterol (INN), or azacosterol hydrochloride (USAN) (brand name Ornitrol), also known as 20,25-diazacholesterol, is a cholesterol-lowering drug (hypocholesteremic) which was marketed previously but has since been discontinued. It is also an avian chemosterilant used to control the pest pigeon population via inducing sterility. The drug is a sterol and derivative of cholesterol in which two carbon atoms have been replaced with nitrogen atoms. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The anti-fertility effects of the drug in birds are mediated by inhibition of steroid hormone production, steroid hormones being synthesized from cholesterol. Due to prevention of the metabolism of desmosterol, the drug causes it to accumulate, in turn producing side effects such as hyperkeratosis, particularly of the palms and soles. [1]

30 relations: Atom, Biosynthesis, Bird, Birth control, Carbon, Chemosterilant, Cholesterol, Columbidae, Derivative (chemistry), Desmosterol, Desmosterolosis, Enzyme inhibitor, Hand, Hydrochloride, Hyperkeratosis, International nonproprietary name, Lipid-lowering agent, Metabolism, Nitrogen, Oral administration, Pest (organism), Side effect, Sole (foot), Sterility (physiology), Steroid hormone, Sterol, Triparanol, United States Adopted Name, X-linked ichthyosis, 24-Dehydrocholesterol reductase.

Atom

An atom is the smallest constituent unit of ordinary matter that has the properties of a chemical element.

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Biosynthesis

Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.

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Bird

Birds, also known as Aves, are a group of endothermic vertebrates, characterised by feathers, toothless beaked jaws, the laying of hard-shelled eggs, a high metabolic rate, a four-chambered heart, and a strong yet lightweight skeleton.

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Birth control

Birth control, also known as contraception and fertility control, is a method or device used to prevent pregnancy.

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Carbon

Carbon (from carbo "coal") is a chemical element with symbol C and atomic number 6.

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Chemosterilant

A chemosterilant is a chemical compound that causes reproductive sterility in an organism.

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Cholesterol

Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.

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Columbidae

Pigeons and doves constitute the animal family Columbidae and the order Columbiformes, which includes about 42 genera and 310 species.

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Derivative (chemistry)

In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.

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Desmosterol

Desmosterol is a molecule similar to cholesterol.

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Desmosterolosis

Desmosterolosis is a defect in cholesterol biosynthesis.

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Hand

A hand is a prehensile, multi-fingered appendage located at the end of the forearm or forelimb of primates such as humans, chimpanzees, monkeys, and lemurs.

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Hydrochloride

In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).

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Hyperkeratosis

Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis), often associated with the presence of an abnormal quantity of keratin,Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Lipid-lowering agent

Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia).

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Nitrogen

Nitrogen is a chemical element with symbol N and atomic number 7.

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Oral administration

| name.

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Pest (organism)

A pest is a plant or animal detrimental to humans or human concerns including crops, livestock, and forestry.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Sole (foot)

The sole is the underside of the foot.

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Sterility (physiology)

Sterility is the physiological inability to effect sexual reproduction in a living thing, members of whose kind have been produced sexually.

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Steroid hormone

A steroid hormone is a steroid that acts as a hormone.

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Sterol

Sterols, also known as steroid alcohols, are a subgroup of the steroids and an important class of organic molecules.

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Triparanol

Triparanol (INN, BAN) (brand and developmental code names MER/29, as well as many other brand names), patented in 1959 and introduced in the United States in 1960, was the first synthetic cholesterol-lowering drug.

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United States Adopted Name

United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.

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X-linked ichthyosis

X-linked ichthyosis (XLI) (also known as ") is a skin condition caused by the hereditary deficiency of the steroid sulfatase (STS) enzyme that affects 1 in 2000 to 1 in 6000 males.

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24-Dehydrocholesterol reductase

24-Dehydrocholesterol reductase is a protein that in humans is encoded by the DHCR24 gene.

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Redirects here:

20,25-Azacholesterol, 20,25-Diazacholesterol, 20,25-azacholesterol, 20,25-diazacholesterol, Azacholesterol, Azacosterol hydrochloride, Azasterol, C25H44N2O, Diazacholesterol, Diazasterol, IMD 760, IMD-760, IMD760, Ornitrol, SC 12,937, SC 12937, SC-12,937, SC-12937, SC12937.

References

[1] https://en.wikipedia.org/wiki/Azacosterol

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