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28 relations: Acid–base homeostasis, Antagonist, Atosiban, Barusiban, Carbonyldiimidazole, Carboxybenzyl, Cytochrome P450, Diastereomer, Enantioselective synthesis, Epelsiban, Epimer, GlaxoSmithKline, Indane, L-368,899, L-371,257, Microsome, Morpholine, Oxazole, Oxytocin receptor, Partition coefficient, Preterm birth, PyBOP, Receptor antagonist, Route of administration, Tocolytic, Ugi reaction, Vasopressin, 2,5-Diketopiperazine.
Acid–base homeostasis
Acid–base homeostasis is the homeostatic regulation of the pH of the body's extracellular fluid (ECF).
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Antagonist
An antagonist is a character, group of characters, institution or concept that stands in or represents opposition against which the protagonist(s) must contend.
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Atosiban
Atosiban (trade names Tractocile, Antocin, Atosiban SUN) is an inhibitor of the hormones oxytocin and vasopressin.
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Barusiban
Barusiban (INN) (code name FE-200440) is a non-peptide drug which is among the most potent and selective oxytocin receptor antagonists known.
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Carbonyldiimidazole
1,1'-Carbonyldiimidazole (CDI) is an organic compound with the molecular formula (C3H3N2)2CO.
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Carboxybenzyl
Carboxybenzyl, symbol Cbz, Cbo (old symbol), or Z (in honor of its inventor Leonidas Zervas), is a carbamate which is often used as an amine protecting group in organic synthesis.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Diastereomer
Diastereomers (sometimes called diastereoisomers) are a type of a stereoisomer.
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Enantioselective synthesis
Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis.
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Epelsiban
Epelsiban (INN, USAN, code name GSK-557,296-B) is an orally bioavailable drug which acts as oxytocin receptor antagonist.
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Epimer
In stereochemistry, an epimer is one of a pair of stereoisomers.
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GlaxoSmithKline
GlaxoSmithKline plc (GSK) is a British pharmaceutical company headquartered in Brentford, London.
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Indane
Indane or indan is a hydrocarbon petrochemical compound, with formula C9H10.
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L-368,899
L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors.
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L-371,257
L-371,257 is a compound used in scientific research which acts as a selective antagonist of the oxytocin receptor with over 800x selectivity over the related vasopressin receptors.
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Microsome
In cell biology, microsomes are vesicle-like artifacts re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.
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Morpholine
Morpholine is an organic chemical compound having the chemical formula O(CH2CH2)2NH.
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Oxazole
Oxazole is the parent compound for a vast class of heterocyclic aromatic organic compounds.
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Oxytocin receptor
The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin.
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Partition coefficient
In the physical sciences, a partition-coefficient (P) or distribution-coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium.
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Preterm birth
Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.
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PyBOP
PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent used in solid phase peptide synthesis.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Route of administration
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body.
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Tocolytic
Tocolytics (also called anti-contraction medications or labor suppressants) are medications used to suppress premature labor (from the Greek tokos, childbirth, and lytic, capable of dissolving).
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Ugi reaction
The Ugi reaction is a multi-component reaction in organic chemistry involving a ketone or aldehyde, an amine, an isocyanide and a carboxylic acid to form a bis-amide.
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Vasopressin
Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.
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2,5-Diketopiperazine
2,5-Diketopiperazine, also known as piperazine-2,5-dione and as the cyclodipeptide cyclo(Gly-Gly), is an organic compound and the smallest cyclic dipeptide that consists of a six-membered ring containing two amide linkages where the two nitrogen atoms and the two carbonyls are at opposite positions in the ring.
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Redirects here:
C27H34N4O5, GSK-221,149-A, GSK-221149, Retosibn, Retosibn (GSK-221,149).
References
[1] https://en.wikipedia.org/wiki/Retosiban
