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20 relations: Alzheimer's disease, Anticholinergic, Antihistamine, Antipruritic, Blood–brain barrier, CYP3A4, Edema, Feces, FIASMA, H1 antagonist, Heart arrhythmia, HERG, Histamine H3 receptor, Itch, Janssen Pharmaceutica, Liver, Median lethal dose, QT interval, Sphingomyelin phosphodiesterase, United States.
Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Anticholinergic
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.
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Antihistamine
Antihistamines are drugs which treat allergic rhinitis and other allergies.
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Antipruritic
Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those from mosquitoes, fleas, and mites, and contact dermatitis and urticaria caused by plants such as poison ivy (urushiol-induced contact dermatitis) or stinging nettle.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Edema
Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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FIASMA
Functional inhibitors of acid sphingomyelinase, or FIASMA, is a term which characterizes a large group of pharmacological compounds inhibiting the enzyme acid sphingomyelinase (ASM, EC 3.1.4.12).
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H1 antagonist
H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H1 receptor, helping to relieve allergic reactions.
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Heart arrhythmia
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
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HERG
hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel.
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Histamine H3 receptor
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.
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Itch
Itch (also known as pruritus) is a sensation that causes the desire or reflex to scratch.
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Janssen Pharmaceutica
Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Median lethal dose
In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a measure of the lethal dose of a toxin, radiation, or pathogen.
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QT interval
In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
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Sphingomyelin phosphodiesterase
Sphingomyelin phosphodiesterase (also known as neutral sphingomyelinase, sphingomyelinase, or SMase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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ATC code R06AX11, ATCvet code QR06AX11, Alermizol, Astemisan, Astemisol, Astemison, C28H31FN4O, Hismanal, Histamen, Histaminos, Histazol, Laridal, Metodik, Nono-Nastizol A, Paralergin, Retolen, Waruzol.
