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56 relations: Addiction, Agonist, Analgesic, Antipruritic, Asimadoline, Butorphanol, Cholestatic pruritus, Chronic kidney disease, Chronic liver disease, Clinical trial, Cocaine, Conditioned place preference, Difelikefalin, Diuretic, Drug tolerance, EC50, Europe, European Medicines Agency, Functional selectivity, Hallucinogen, Hemodialysis, Insomnia, International nonproprietary name, Intramuscular injection, Intravenous therapy, Japan, Ligand (biochemistry), Marketing Authorization Application, Mecamylamine, Model organism, Molecular modification, Morphinan, Morphine, Nalbuphine, Nalmefene, Naltrexone, Naltriben, Narcotic, Nicotine withdrawal, Nociception, Noribogaine, Opioid, Opioid antagonist, Partial agonist, Physical dependence, Psychological dependence, RB-64, Salvinorin A, Sedative, Side effect, ..., Substance abuse, Surgery, U-50488, United States, United States Adopted Name, Uremic pruritus. Expand index (6 more) »
Addiction
Addiction is a brain disorder characterized by compulsive engagement in rewarding stimuli despite adverse consequences.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Antipruritic
Antipruritics, also known as anti-itch drugs, are medications that inhibit the itching (Latin: pruritus) often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those from mosquitoes, fleas, and mites, and contact dermatitis and urticaria caused by plants such as poison ivy (urushiol-induced contact dermatitis) or stinging nettle.
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Asimadoline
Asimadoline (EMD-61753) is a drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist.
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Butorphanol
Butorphanol (BC 2627) is a morphinan-type synthetic agonist–antagonist opioid analgesic developed by Bristol-Myers.
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Cholestatic pruritus
Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cirrhosis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.
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Chronic kidney disease
Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months or years.
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Chronic liver disease
Chronic liver disease in the clinical context is a disease process of the liver that involves a process of progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Cocaine
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.
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Conditioned place preference
Conditioned place preference (CPP) is a form of Pavlovian conditioning used to measure the motivational effects of objects or experiences.
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Difelikefalin
Difelikefalin (INN) (developmental code names CR845, FE-202845), also known as D-Phe-D-Phe-D-Leu-D-Lys- (as the acetate salt), is an analgesic opioid peptide acting as a peripherally specific, highly selective agonist of the κ-opioid receptor (KOR).
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Diuretic
A diuretic is any substance that promotes diuresis, the increased production of urine.
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Drug tolerance
Drug tolerance is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.
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EC50
Half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.
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Europe
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.
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European Medicines Agency
The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.
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Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
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Hallucinogen
A hallucinogen is a psychoactive agent which can cause hallucinations, perceptual anomalies, and other substantial subjective changes in thoughts, emotion, and consciousness.
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Hemodialysis
Hemodialysis, also spelled haemodialysis, commonly called kidney dialysis or simply dialysis, is a process of purifying the blood of a person whose kidneys are not working normally.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Intramuscular injection
Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.
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Intravenous therapy
Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).
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Japan
Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Marketing Authorization Application
Marketing Authorisation Application (MAA) is an application submitted by a drug manufacturer seeking permission to bring a newly developed medicinal product (for example, a new medicine) to the market.
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Mecamylamine
Mecamylamine (INN, BAN; or mecamylamine hydrochloride (USAN); brand names Inversine, Vecamyl) is a non-selective, non-competitive antagonist of the nicotinic acetylcholine receptors (nAChRs) that was introduced in the 1950s as an antihypertensive drug.
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Model organism
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.
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Molecular modification
Molecular modification is chemical alteration of a known and previously characterized lead compound for the purpose of enhancing its usefulness as a drug.
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Morphinan
Morphinan is the prototype chemical structure of a large chemical class of psychoactive drugs, consisting of opiate analgesics, cough suppressants, and dissociative hallucinogens, among others.
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Morphine
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.
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Nalbuphine
Nalbuphine, sold under the brand names Nubain and Nalpain among others, is a opioid analgesic which is used in the treatment of pain.
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Nalmefene
Nalmefene (trade name Selincro), originally known as nalmetrene, is an opioid antagonist used primarily in the management of alcohol dependence.
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Naltrexone
Naltrexone, sold under the brand names ReVia and Vivitrol among others, is a medication primarily used to manage alcohol or opioid dependence.
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Naltriben
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research.
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Narcotic
The term narcotic (from ancient Greek ναρκῶ narkō, "to make numb") originally referred medically to any psychoactive compound with sleep-inducing properties.
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Nicotine withdrawal
Nicotine withdrawal is a group of symptoms that occur in the first few weeks upon the abrupt discontinuation or decrease in intake of nicotine.
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Nociception
Nociception (also nocioception or nociperception, from Latin nocere 'to harm or hurt') is the sensory nervous system's response to certain harmful or potentially harmful stimuli.
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Noribogaine
Noribogaine (actually O-desmethylibogaine), or 12-hydroxyibogamine, is the principal psychoactive metabolite of the oneirogen ibogaine.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Opioid antagonist
An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors.
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Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
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Physical dependence
Physical dependence is a physical condition caused by chronic use of a tolerance forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.
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Psychological dependence
Psychological dependence is a form of dependence that involves emotional–motivational withdrawal symptoms (e.g., a state of unease or dissatisfaction, a reduced capacity to experience pleasure, or anxiety) upon cessation of drug use or exposure to a stimulus.
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RB-64
RB-64 or 22-thiocyanatosalvinorin A is a semi-synthetic salvinorin derivative and a κ-opioid receptor (KOR) agonist which is used in scientific research.
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Salvinorin A
Salvinorin A is the main active psychotropic molecule in Salvia divinorum, a Mexican plant which has a long history of use as an entheogen by indigenous Mazatec shamans.
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Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Substance abuse
Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.
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Surgery
Surgery (from the χειρουργική cheirourgikē (composed of χείρ, "hand", and ἔργον, "work"), via chirurgiae, meaning "hand work") is a medical specialty that uses operative manual and instrumental techniques on a patient to investigate or treat a pathological condition such as a disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas.
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U-50488
U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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United States Adopted Name
United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.
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Uremic pruritus
Uremic pruritus (also known as uraemic pruritus or renal pruritus) is caused by chronic kidney failure and is the most common internal systemic cause of itching.
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Redirects here:
ATC code V03AX02, ATCvet code QV03AX02, C28H32N2O5, Nalfurafine hydrochloride, TRK-820.
References
[1] https://en.wikipedia.org/wiki/Nalfurafine
