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Discodermolide

Index Discodermolide

(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. [1]

102 relations: A549 cell, Acetylene, Aldehyde, Aldol reaction, Alkene, Alkyl, Alkylation, Allyl group, American Society of Clinical Oncology, Amos Smith, Amyloid, Antifungal, Apoptosis, Axon, Benzyl group, Boron trifluoride, Cancer, Carbamate, Caribbean, Catalytic triad, Cell cycle, Cell growth, Chelation, Chemotherapy, Chiral auxiliary, Clinical trial, Conformational isomerism, Crystal, Cytoplasm, Cytostasis, Diastereomer, Diels–Alder reaction, Diene, Diisobutylaluminium hydride, Diol, Discodermia dissoluta, Enol, Enzyme, Epothilone, Ether, Fermentation, Guanosine triphosphate, Halogenation, Harbor Branch Oceanographic Institute, HCT116 cells, HeLa, Hemiacetal, Homologation, Horner–Wadsworth–Emmons reaction, Immortalised cell line, ..., Immunosuppression, In vitro, In vivo, Isomer, Journal of Organic Chemistry, Kosan Biosciences, Lactone, List of breast cancer cell lines, Lymphatic system, Lymphocyte, Microtubule, Mitochondrion, Murinae, Natural product, Neuron, Neuroprotection, Neurotransmitter, Novartis, Paclitaxel, Palladium, Patient, Pentane, Peripheral, Phases of clinical research, Phenotype, Phosphonium, Polyketide, Polymerization, Precursor (chemistry), Racemic mixture, Schwartz's reagent, Senescence, Sodium borohydride, Splenocyte, Sponge, Stereoselectivity, Stuart Schreiber, Suzuki, Suzuki reaction, Swern oxidation, Tau protein, Tauopathy, Tin, Titanium, Tubulin, University of Cambridge, Vesicle (biology and chemistry), Vinyl group, Vinyl halide, White blood cell, X-ray crystallography, 2-Oxazolidone. Expand index (52 more) »

A549 cell

A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al.

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Acetylene

Acetylene (systematic name: ethyne) is the chemical compound with the formula C2H2.

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Aldehyde

An aldehyde or alkanal is an organic compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain.

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Aldol reaction

The aldol reaction is a means of forming carbon–carbon bonds in organic chemistry.

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Alkene

In organic chemistry, an alkene is an unsaturated hydrocarbon that contains at least one carbon–carbon double bond.

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Alkyl

In organic chemistry, an alkyl substituent is an alkane missing one hydrogen.

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Alkylation

Alkylation is the transfer of an alkyl group from one molecule to another.

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Allyl group

An allyl group is a substituent with the structural formula H2C.

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American Society of Clinical Oncology

The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer.

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Amos Smith

Amos B. Smith III (born August 26, 1944) is an American chemist.

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Amyloid

Amyloids are aggregates of proteins that become folded into a shape that allows many copies of that protein to stick together forming fibrils.

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Antifungal

An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Axon

An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.

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Benzyl group

In organic chemistry, benzyl is the substituent or molecular fragment possessing the structure C6H5CH2–.

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Boron trifluoride

Boron trifluoride is the inorganic compound with the formula BF3.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Carbamate

A carbamate is an organic compound derived from carbamic acid (NH2COOH).

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Caribbean

The Caribbean is a region that consists of the Caribbean Sea, its islands (some surrounded by the Caribbean Sea and some bordering both the Caribbean Sea and the North Atlantic Ocean) and the surrounding coasts.

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Catalytic triad

A catalytic triad is a set of three coordinated amino acids that can be found in the active site of some enzymes.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Cell growth

The term cell growth is used in the contexts of biological cell development and cell division (reproduction).

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Chelation

Chelation is a type of bonding of ions and molecules to metal ions.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Chiral auxiliary

A chiral auxiliary is a stereogenic group or unit that is temporarily incorporated into an organic compound in order to control the stereochemical outcome of the synthesis.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Conformational isomerism

In chemistry, conformational isomerism is a form of stereoisomerism in which the isomers can be interconverted just by rotations about formally single bonds (refer to figure on single bond rotation).

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Crystal

A crystal or crystalline solid is a solid material whose constituents (such as atoms, molecules, or ions) are arranged in a highly ordered microscopic structure, forming a crystal lattice that extends in all directions.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Cytostasis

Cytostasis (cyto – cell; stasis – stoppage) is the inhibition of cell growth and multiplication.

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Diastereomer

Diastereomers (sometimes called diastereoisomers) are a type of a stereoisomer.

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Diels–Alder reaction

The Diels–Alder reaction is an organic chemical reaction (specifically, a cycloaddition) between a conjugated diene and a substituted alkene, commonly termed the dienophile, to form a substituted cyclohexene derivative.

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Diene

In organic chemistry a diene or diolefin is a hydrocarbon that contains two carbon double bonds.

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Diisobutylaluminium hydride

Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2).

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Diol

A diol or glycol is a chemical compound containing two hydroxyl groups (−OH groups).

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Discodermia dissoluta

Discodermia dissoluta is a deep-water marine sponge found in the Eastern, Southern, and Southwestern Caribbean, and in the Greater Antilles.

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Enol

Enols, or more formally, alkenols, are a type of reactive structure or intermediate in organic chemistry that is represented as an alkene (olefin) with a hydroxyl group attached to one end of the alkene double bond.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Epothilone

The epothilones are a class of potential cancer drugs.

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Ether

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups.

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Fermentation

Fermentation is a metabolic process that consumes sugar in the absence of oxygen.

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Guanosine triphosphate

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate.

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Halogenation

Halogenation is a chemical reaction that involves the addition of one or more halogens to a compound or material.

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Harbor Branch Oceanographic Institute

Harbor Branch Oceanographic Institute at Florida Atlantic University, also commonly referred to as HBOI or HBOI at FAU, is a non-profit oceanographic institution operated by Florida Atlantic University in Fort Pierce, Florida, United States.

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HCT116 cells

HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings.

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HeLa

HeLa (also Hela or hela) is a cell type in an immortal cell line used in scientific research.

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Hemiacetal

A hemiacetal or a hemiketal is a compound that results from the addition of an alcohol to an aldehyde or a ketone, respectively.

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Homologation

Homologation (Greek homologeo, ὁμολογέω, "to agree") is the granting of approval by an official authority.

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Horner–Wadsworth–Emmons reaction

The Horner–Wadsworth–Emmons (HWE) reaction is a chemical reaction used in organic chemistry of stabilized phosphonate carbanions with aldehydes (or ketones) to produce predominantly E-alkenes.

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Immortalised cell line

An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.

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Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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Isomer

An isomer (from Greek ἰσομερής, isomerès; isos.

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Journal of Organic Chemistry

The Journal of Organic Chemistry, colloquially known as JOC or J Org, is a peer-reviewed scientific journal for original contributions of fundamental research in all branches of theory and practice in organic and bioorganic chemistry.

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Kosan Biosciences

Kosan Biosciences, Inc. (stock symbol: KOSN), is a pharmaceutical company which deals with cancer therapeutics medications.

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Lactone

Lactones are cyclic esters of hydroxycarboxylic acids, containing a 1-oxacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.

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List of breast cancer cell lines

Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease.

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Lymphatic system

The lymphatic system is part of the vascular system and an important part of the immune system, comprising a network of lymphatic vessels that carry a clear fluid called lymph (from Latin, lympha meaning "water") directionally towards the heart.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Microtubule

Microtubules are tubular polymers of tubulin that form part of the cytoskeleton that provides the cytoplasm of eukaryotic cells and some bacteria with structure and shape.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Murinae

The Old World rats and mice, part of the subfamily Murinae in the family Muridae, comprise at least 519 species.

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Natural product

A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.

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Neuron

A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neuroprotection

Neuroprotection refers to the relative preservation of neuronal structure and/or function.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Novartis

Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland.

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Paclitaxel

Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer.

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Palladium

Palladium is a chemical element with symbol Pd and atomic number 46.

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Patient

A patient is any recipient of health care services.

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Pentane

Pentane is an organic compound with the formula C5H12—that is, an alkane with five carbon atoms.

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Peripheral

A peripheral device is "an ancillary device used to put information into and get information out of the computer." Three categories of peripheral devices exist based on their relationship with the computer.

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Phases of clinical research

The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment.

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Phenotype

A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).

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Phosphonium

The phosphonium (more obscurely: phosphinium) cation describes polyatomic cations with the chemical formula.

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Polyketide

Polyketides are a class of secondary metabolites produced by certain living organisms in order to impart to them some survival advantage.

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Polymerization

In polymer chemistry, polymerization is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks.

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Precursor (chemistry)

In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.

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Racemic mixture

In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.

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Schwartz's reagent

Schwartz's reagent is the common name for the chemical compound with the formula (C5H5)2ZrHCl, sometimes called zirconocene hydrochloride or zirconocene chloride hydride, and is named after Jeffrey Schwartz, a chemistry professor at Princeton University.

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Senescence

Senescence or biological ageing is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.

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Sodium borohydride

Sodium borohydride, also known as sodium tetrahydridoborate and sodium tetrahydroborate, is an inorganic compound with the formula NaBH4.

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Splenocyte

A splenocyte can be any one of the different white blood cell types as long as it is situated in the spleen or purified from splenic tissue.

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Sponge

Sponges, the members of the phylum Porifera (meaning "pore bearer"), are a basal Metazoa clade as sister of the Diploblasts.

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Stereoselectivity

In chemistry, stereoselectivity is the property of a chemical reaction in which a single reactant forms an unequal mixture of stereoisomers during the non-stereospecific creation of a new stereocenter or during the non-stereospecific transformation of a pre-existing one.

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Stuart Schreiber

Stuart L. Schreiber (born 6 February 1956) is a scientist at Harvard University and co-Founder of the Broad Institute.

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Suzuki

is a Japanese multinational corporation headquartered in Minami-ku, Hamamatsu, that manufactures automobiles, four-wheel drive vehicles, motorcycles, all-terrain vehicles (ATVs), outboard marine engines, wheelchairs and a variety of other small internal combustion engines.

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Suzuki reaction

The Suzuki reaction is an organic reaction, classified as a coupling reaction, where the coupling partners are a boronic acid and an organohalide catalyzed by a palladium(0) complex.

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Swern oxidation

The Swern oxidation, named after Daniel Swern, is a chemical reaction whereby a primary or secondary alcohol is oxidized to an aldehyde or ketone using oxalyl chloride, dimethyl sulfoxide (DMSO) and an organic base, such as triethylamine.

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Tau protein

Tau proteins (or τ proteins, after the Greek letter with that name) are proteins that stabilize microtubules.

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Tauopathy

Tauopathy belongs to a class of neurodegenerative diseases associated with the pathological aggregation of tau protein in neurofibrillary or gliofibrillary tangles in the human brain.

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Tin

Tin is a chemical element with the symbol Sn (from stannum) and atomic number 50.

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Titanium

Titanium is a chemical element with symbol Ti and atomic number 22.

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Tubulin

Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.

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University of Cambridge

The University of Cambridge (informally Cambridge University)The corporate title of the university is The Chancellor, Masters, and Scholars of the University of Cambridge.

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Vesicle (biology and chemistry)

In cell biology, a vesicle is a small structure within a cell, or extracellular, consisting of fluid enclosed by a lipid bilayer.

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Vinyl group

In chemistry, vinyl or ethenyl is the functional group with the formula −CH.

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Vinyl halide

In organic chemistry, a vinyl halide is a compound with the formula CH2.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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X-ray crystallography

X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.

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2-Oxazolidone

2-Oxazolidone is a heterocyclic organic compound containing both nitrogen and oxygen in a 5-membered ring.

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C33H55NO8.

References

[1] https://en.wikipedia.org/wiki/Discodermolide

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