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23 relations: Adrenal medulla, Agonist, Amide, Analgesic, Bond cleavage, Bovinae, Brain, C-terminus, Endogeny (biology), Human, Hypoventilation, Δ-opioid receptor, Κ-opioid receptor, Μ-opioid receptor, Mammal, Neoplasm, Opioid, Opioid peptide, Peptide, Pheochromocytoma, Potency (pharmacology), Proenkephalin, Proteolysis.
Adrenal medulla
The adrenal medulla (medulla glandulae suprarenalis) is part of the adrenal gland.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Amide
An amide (or or), also known as an acid amide, is a compound with the functional group RnE(O)xNR′2 (R and R′ refer to H or organic groups).
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Bond cleavage
Bond cleavage, or scission, is the splitting of chemical bonds.
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Bovinae
The biological subfamily Bovinae includes a diverse group of 10 genera of medium to large-sized ungulates, including domestic cattle, bison, African buffalo, the water buffalo, the yak, and the four-horned and spiral-horned antelopes.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Endogeny (biology)
Endogenous substances and processes are those that originate from within an organism, tissue, or cell.
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Human
Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.
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Hypoventilation
Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate (hypo meaning "below") to perform needed gas exchange.
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Δ-opioid receptor
The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins as its endogenous ligands.
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Κ-opioid receptor
The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.
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Μ-opioid receptor
The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins.
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Mammal
Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.
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Neoplasm
Neoplasia is a type of abnormal and excessive growth of tissue.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Opioid peptide
Opioid peptides are peptides that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Pheochromocytoma
Pheochromocytoma (PCC) is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue that failed to involute after birth, that secretes high amounts of catecholamines, mostly norepinephrine, plus epinephrine to a lesser extent.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Proenkephalin
Proenkephalin (PENK), formerly known as proenkephalin A (since proenkephalin B was renamed prodynorphin), is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides Metenkephalin, and to a lesser extent, Leuenkephalin.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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References
[1] https://en.wikipedia.org/wiki/Adrenorphin
