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Pyroglutamic acid

Index Pyroglutamic acid

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. [1]

23 relations: Alzheimer's disease, Amino acid, Amyloid beta, Bacteriorhodopsin, Condensation reaction, Dietary supplement, Edman degradation, Enantiomer, Glutamic acid, Glutamine, Glutaminyl-peptide cyclotransferase, Glutathione, High anion gap metabolic acidosis, Humectant, Inborn errors of metabolism, Lactam, Magnesium pidolate, Mineral (nutrient), Paracetamol poisoning, Pyroglutamate aminopeptidase, Salt (chemistry), Sodium, Xeroderma.

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Amyloid beta

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients.

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Bacteriorhodopsin

Bacteriorhodopsin is a protein used by Archaea, most notably by Halobacteria, a class of the Euryarchaeota.

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Condensation reaction

A condensation reaction is a class of an organic addition reaction that proceeds in a step-wise fashion to produce the addition product, usually in equilibrium, and a water molecule (hence named condensation).

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Dietary supplement

A dietary supplement is a manufactured product intended to supplement the diet when taken by mouth as a pill, capsule, tablet, or liquid.

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Edman degradation

Edman degradation, developed by Pehr Edman, is a method of sequencing amino acids in a peptide.

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Enantiomer

In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Glutamine

Glutamine (symbol Gln or Q) is an α-amino acid that is used in the biosynthesis of proteins.

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Glutaminyl-peptide cyclotransferase

In enzymology, a glutaminyl-peptide cyclotransferase is an enzyme that catalyzes the chemical reaction Hence, this enzyme has one substrate, L-glutaminyl-peptide or L-glutamyl-peptide, and two products, 5-oxoprolyl-peptide and NH3 or H2O.

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Glutathione

Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea.

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High anion gap metabolic acidosis

When acidosis is present on blood tests, the first step in determining the cause is determining the anion gap.

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Humectant

A humectant is a hygroscopic substance used to keep things moist; it is the opposite of a desiccant because it is wet.

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Inborn errors of metabolism

Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of metabolism.

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Lactam

A lactam is a cyclic amide.

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Magnesium pidolate

Magnesium pidolate, the magnesium salt of pidolic acid (pyroglutamic acid), is a mineral supplement, which contains 8.664% magnesium w/w.

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Mineral (nutrient)

In the context of nutrition, a mineral is a chemical element required as an essential nutrient by organisms to perform functions necessary for life.

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Paracetamol poisoning

Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the medication paracetamol (acetaminophen).

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Pyroglutamate aminopeptidase

Pyroglutamate aminopeptidase is a type of enzyme that cleaves the peptide bond linking the N-terminal end of a polypeptide forming a cyclical lactam to the next amino acid residue.

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Salt (chemistry)

In chemistry, a salt is an ionic compound that can be formed by the neutralization reaction of an acid and a base.

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Sodium

Sodium is a chemical element with symbol Na (from Latin natrium) and atomic number 11.

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Xeroderma

Xeroderma or xerodermia (also known as xerosis cutis), derived from the Greek words for "dry skin", is a condition involving the integumentary system, which in most cases can safely be treated with emollients or moisturizers.

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Redirects here:

2-oxo-pyrrolidine carboxylic acid, 5-Oxoproline, 5-oxoproline, C5H7NO3, Oxoproline, Pidolic acid, Pyroglutamate, Pyrrolidonecarboxylic acid.

References

[1] https://en.wikipedia.org/wiki/Pyroglutamic_acid

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