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16 relations: Adenine, Adozelesin, Alkylation, Antibody-drug conjugate, Dale L. Boger, DU145, Duocarmycin, HCT116 cells, L1210 cells, Mechanism of action, Natural product, NCI-60, Nucleic acid double helix, Pharmacophore, Streptomyces, Synthon (company).
Adenine
Adenine (A, Ade) is a nucleobase (a purine derivative).
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Adozelesin
Adozelesin is an experimental antitumor drug of the duocarmycin class.
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Alkylation
Alkylation is the transfer of an alkyl group from one molecule to another.
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Antibody-drug conjugate
Antibody-drug conjugates or ADCs are an important class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer.
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Dale L. Boger
Dale Lester Boger is an American medicinal and organic chemist and chair of the Department of Chemistry at The Scripps Research Institute in La Jolla, CA.
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DU145
DU145 (DU-145) is a human prostate cancer cell line.
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Duocarmycin
The duocarmycins are members of a series of related natural products first isolated from Streptomyces bacteria in 1988.
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HCT116 cells
HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings.
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L1210 cells
L1210 is a mouse lymphocytic leukemia cell line which is derived from the ascitic fluid of 8-month-old female mice.
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Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
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Natural product
A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.
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NCI-60
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity.
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Nucleic acid double helix
In molecular biology, the term double helix refers to the structure formed by double-stranded molecules of nucleic acids such as DNA.
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Pharmacophore
An example of a pharmacophore model. A pharmacophore is an abstract description of molecular features that are necessary for molecular recognition of a ligand by a biological macromolecule.
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Streptomyces
Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae.
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Synthon (company)
Synthon is a Dutch multinational that produces generic human drugs.
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