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Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. [1]

23 relations: Alum, C57BL/6, CD3 (immunology), CD4, CTLA-4, Cytokine, Freund's adjuvant, Gene, ICOSLG, Immune checkpoint, Immunoglobulin E, Immunoglobulin G, In vitro, Interferon gamma, Interleukin 2, Interleukin 4, Interleukin 5, Ipilimumab, Keyhole limpet hemocyanin, Ligand, Protein dimer, T cell, T helper cell.


An alum is a type of chemical compound, usually a hydrated double sulfate salt of aluminium with the general formula, where X is a monovalent cation such as potassium or ammonium.

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C57BL/6, often referred to as "C57 black 6", "C57" or "black 6" (standard abbreviation: B6), is a common inbred strain of laboratory mouse.

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CD3 (immunology)

In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).

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In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.

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Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Freund's adjuvant

Freund's adjuvant is a solution of antigen emulsified in mineral oil and used as an immunopotentiator (booster).

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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ICOS ligand is a protein that in humans is encoded by the ICOSLG gene.

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Immune checkpoint

Immune checkpoints are regulators of the immune system.

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Immunoglobulin E

Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals.

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Immunoglobulin G

Immunoglobulin G (IgG) is a type of antibody.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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Interferon gamma

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.

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Interleukin 2

Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.

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Interleukin 4

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.

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Interleukin 5

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells.

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Ipilimumab (trade name Yervoy) is a monoclonal antibody that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system.

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Keyhole limpet hemocyanin

Keyhole limpet hemocyanin (KLH) is a large, multisubunit, oxygen-carrying, metalloprotein that is found in the hemolymph of the giant keyhole limpet, Megathura crenulata, a species of keyhole limpet that lives off the coast of California, from Monterey Bay to Isla Asuncion off Baja California.

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In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T helper cell

The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.

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ICOS (gene), Inducible T-cell costimulator.


[1] https://en.wikipedia.org/wiki/CD278

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