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CD44

Index CD44

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. [1]

65 relations: Alternative splicing, Angiogenesis, Antibody, Antisense therapy, Apoptosis, ARHGEF1, Beta-catenin, BGMUT, Bivatuzumab, Cancer cell, Cancer stem cell, Carboxyfluorescein succinimidyl ester, Cell (biology), Cell adhesion molecule, Cell growth, Cell membrane, Cell migration, Cellular differentiation, Chemokine, Collagen, Cytokine, Downregulation and upregulation, Endometriosis, Epithelium, Exon, Ezrin, Fibrin, Fibrinogen, Fibronectin, FYN, Gene, Glycoprotein, Haematopoiesis, Head and neck cancer, Homing (hematopoietic), Hyaluronic acid, IL2RA, Indian blood group system, Information Hyperlinked over Proteins, Lck, Ligand, Lymphocyte, Matrix metalloproteinase, Mesenchymal stem cell, Metastasis, Monoclonal antibody, National Center for Biotechnology Information, National Institutes of Health, Neoplasm, Non-Hodgkin lymphoma, ..., Osteopontin, Ovarian cancer, Phosphatidylinositol 4,5-bisphosphate, Post-translational modification, Protease, Protein isoform, Protein–protein interaction, Proto-oncogene tyrosine-protein kinase Src, Receptor (biochemistry), Renal cell carcinoma, Selectin, T cell, Thymus, Transcription (biology), Wnt signaling pathway. Expand index (15 more) »

Alternative splicing

Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.

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Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Antisense therapy

Antisense therapy is a form of treatment for genetic disorders or infections.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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ARHGEF1

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.

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Beta-catenin

Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.

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BGMUT

The BGMUT (Blood Group antigen gene MUTation) Database documents allelic variations in the genes encoding for human blood group systems.

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Bivatuzumab

Bivatuzumab (previously BIWA 4) is a humanized monoclonal antibody against CD44 v6.

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Cancer cell

Cancer cells are cells that divide relentlessly, forming solid tumors or flooding the blood with abnormal cells.

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Cancer stem cell

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample.

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Carboxyfluorescein succinimidyl ester

Carboxyfluorescein succinimidyl ester (CFSE) is a fluorescent cell staining dye.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell adhesion molecule

Cell adhesion molecules (CAMs) are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion.

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Cell growth

The term cell growth is used in the contexts of biological cell development and cell division (reproduction).

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Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).

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Cell migration

Cell migration is a central process in the development and maintenance of multicellular organisms.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Chemokine

Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.

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Collagen

Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Downregulation and upregulation

In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.

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Endometriosis

Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the inside of the uterus, grows outside of it.

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Epithelium

Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

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Exon

An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

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Ezrin

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.

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Fibrin

Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.

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Fibrinogen

Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood.

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Fibronectin

Fibronectin is a high-molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.

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FYN

Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glycoprotein

Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to amino acid side-chains.

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Haematopoiesis

Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.

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Head and neck cancer

Head and neck cancer is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands.

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Homing (hematopoietic)

Homing is the phenomenon whereby cells migrate to the organ of their origin.

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Hyaluronic acid

Hyaluronic acid (HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.

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IL2RA

Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.

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Indian blood group system

The Indian blood group system (In) is a classification of blood based on the presence or absence of inherited antigens that reside within the CD44 molecule that is expressed on the surface of blood cells.

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Information Hyperlinked over Proteins

Information Hyperlinked over Proteins (or iHOP) is an online text-mining service that provides a gene-guided network to access PubMed abstracts.

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Lck

Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside specialized cells of the immune system called lymphocytes.

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Ligand

In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Matrix metalloproteinase

Matrix metalloproteinases (MMPs), also known as matrixins, are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins.

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Mesenchymal stem cell

Mesenchymal stem cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).

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Metastasis

Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; it is typically spoken of as such spread by a cancerous tumor.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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National Center for Biotechnology Information

The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).

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National Institutes of Health

The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research, founded in the late 1870s.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.

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Osteopontin

Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).

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Ovarian cancer

Ovarian cancer is a cancer that forms in or on an ovary.

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Phosphatidylinositol 4,5-bisphosphate

Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes.

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Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

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Protease

A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.

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Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Proto-oncogene tyrosine-protein kinase Src

Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src, is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Renal cell carcinoma

Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.

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Selectin

The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs).

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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Thymus

The thymus is a specialized primary lymphoid organ of the immune system.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Wnt signaling pathway

The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors.

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Redirects here:

Antigens, cd44, CD44 (gene), CSPG8, Cd44, Cd44 antigens, HCAM, HCELL.

References

[1] https://en.wikipedia.org/wiki/CD44

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