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28 relations: ANO1, Aspergillus fumigatus, Bestrophin 1, Bestrophin-2, Caenorhabditis elegans, Calcium-dependent chloride channel, Chloride, CLCA1, CLCA2, CLCA3, CLCA4, Drosophila, Endothelium, Epithelium, Eukaryote, Interstitial cell of Cajal, Ion channel, Ligand-gated ion channel, National Center for Biotechnology Information, Neoplasm, Peristalsis, Phospholipid scramblase, Saccharomyces cerevisiae, Silencer (firearms), Smooth muscle tissue, Transporter Classification Database, Vertebrate, Voltage-gated ion channel.
ANO1
Anoctamin-1 (ANO1) also known as Transmembrane member 16A (TMEM16A) is a protein that, in humans, is encoded by the ANO1 gene.
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Aspergillus fumigatus
Aspergillus fumigatus is a fungus of the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency.
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Bestrophin 1
Bestrophin-1 (Best1) is a protein that, in humans, is encoded by the BEST1 gene (RPD ID - 5T5N/4RDQ).
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Bestrophin-2
Bestrophin-2 is a protein that in humans is encoded by the BEST2 gene.
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Caenorhabditis elegans
Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.
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Calcium-dependent chloride channel
The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels (CaCCs), are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory (CLCA), bestrophin (BEST), and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis. In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors. These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals. Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues (aas) in length and exhibit 7 to 10 transmembrane segments (TMSs).
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Chloride
The chloride ion is the anion (negatively charged ion) Cl−.
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CLCA1
Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.
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CLCA2
Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.
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CLCA3
Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene.
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CLCA4
Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene.
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Drosophila
Drosophila is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
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Eukaryote
Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).
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Interstitial cell of Cajal
The interstitial cell of Cajal (ICC) is a type of interstitial cell found in the gastrointestinal tract.
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Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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National Center for Biotechnology Information
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).
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Neoplasm
Neoplasia is a type of abnormal and excessive growth of tissue.
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Peristalsis
Peristalsis is a radially symmetrical contraction and relaxation of muscles that propagates in a wave down a tube, in an anterograde direction.
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Phospholipid scramblase
Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane.
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Saccharomyces cerevisiae
Saccharomyces cerevisiae is a species of yeast.
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Silencer (firearms)
A silencer, suppressor, sound suppressor, or sound moderator is a device that reduces the sound intensity and muzzle flash when a firearm or air gun is discharged.
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Smooth muscle tissue
Smooth muscle is an involuntary non-striated muscle.
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Transporter Classification Database
The Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels.
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Vertebrate
Vertebrates comprise all species of animals within the subphylum Vertebrata (chordates with backbones).
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Voltage-gated ion channel
Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential near the channel.
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Anoctamin, Anoctamins, Bestrophin, Bestrophins, CLCA, CaCC, Calcium-activated chloride channel, Chloride channel accessories, Chloride channel accessory.
References
[1] https://en.wikipedia.org/wiki/Calcium-dependent_chloride_channel
