47 relations: Androgen receptor, Anti-SSA/Ro autoantibodies, Antibody, Calcium, Calnexin, CD47, Chaperone (protein), Chemical affinity, DNA-binding domain, Endoplasmic reticulum, ER retention, Essential thrombocythemia, Frameshift mutation, Gene, Glucocorticoid receptor, Glycosylation, Golgi apparatus, Hormone response element, Immunoglobulin G, Immunoglobulin M, Inositol trisphosphate, Ion, Janus kinase 2, Lupus erythematosus, Macrophage, MHC class I, Myelofibrosis, Myeloid leukemia, Myeloproliferative neoplasm, N-terminus, NK2 homeobox 1, Non-Hodgkin lymphoma, Nuclear receptor, Oligosaccharide, PDIA3, Peptide synthesis, Perforin, Protein, Protein–protein interaction, Retinoic acid receptor, Second messenger system, Signal transduction, Sjögren syndrome, Tapasin, Thrombopoietin receptor, Transporter associated with antigen processing, Valence (chemistry).
Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
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Anti-SSA/Ro autoantibodies
Anti-SSA autoantibodies (Anti-Sjögren’s-syndrome-related antigen A, also called anti-Ro, or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous lupus erythematosus (SCLE), neonatal lupus and primary biliary cirrhosis.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Calcium
Calcium is a chemical element with symbol Ca and atomic number 20.
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Calnexin
Calnexin (CNX) is a integral protein (that appears variously as a 90kDa, 80kDa, or 75kDa band on western blotting depending on the source of the antibody) of the endoplasmic reticulum (ER).
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CD47
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.
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Chaperone (protein)
In molecular biology, molecular chaperones are proteins that assist the covalent folding or unfolding and the assembly or disassembly of other macromolecular structures.
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Chemical affinity
In chemical physics and physical chemistry, chemical affinity is the electronic property by which dissimilar chemical species are capable of forming chemical compounds.
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DNA-binding domain
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.
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Endoplasmic reticulum
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
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ER retention
ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins.
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Essential thrombocythemia
Essential thrombocythemia (ET) is a rare chronic blood condition characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow.
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Frameshift mutation
A frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glucocorticoid receptor
The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.
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Glycosylation
Glycosylation (see also chemical glycosylation) is the reaction in which a carbohydrate, i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor).
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Golgi apparatus
The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells.
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Hormone response element
A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind to a specific hormone receptor complex and therefore regulate transcription.
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Immunoglobulin G
Immunoglobulin G (IgG) is a type of antibody.
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Immunoglobulin M
Immunoglobulin M (IgM) is one of several forms of antibody that are produced by vertebrates.
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Inositol trisphosphate
Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or Ins3P or IP3), together with diacylglycerol (DAG), is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells.
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Ion
An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).
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Janus kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase.
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Lupus erythematosus
Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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MHC class I
MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates.
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Myelofibrosis
Myelofibrosis, also known as osteomyelofibrosis, is a relatively rare bone marrow cancer.
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Myeloid leukemia
Myeloid leukemia is a type of leukemia affecting myeloid tissue.
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Myeloproliferative neoplasm
The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone marrow in which excess cells are produced.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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NK2 homeobox 1
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
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Non-Hodgkin lymphoma
Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.
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Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
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Oligosaccharide
An oligosaccharide (from the Greek ὀλίγος olígos, "a few", and σάκχαρ sácchar, "sugar") is a saccharide polymer containing a small number (typically three to ten) of monosaccharides (simple sugars).
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PDIA3
Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme.
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Peptide synthesis
In organic chemistry, peptide synthesis is the production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds.
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Perforin
Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Retinoic acid receptor
The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid.
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Second messenger system
Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Sjögren syndrome
Sjögren syndrome (SjS, SS) is a long-term autoimmune disease in which the moisture-producing glands of the body are affected.
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Tapasin
TAP-associated glycoprotein also known as tapasin or TAPBP is a protein that in humans is encoded by the TAPBP gene.
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Thrombopoietin receptor
The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.
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Transporter associated with antigen processing
Transporter associated with antigen processing (TAP) is a member of the ATP-binding-cassette transporter family.
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Valence (chemistry)
In chemistry, the valence or valency of an element is a measure of its combining power with other atoms when it forms chemical compounds or molecules.
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Redirects here:
Autoantigen Ro, CALR, CALR (gene), CRP55, CaBP3, Calregulin, Calsequestrin-like protein, Mobilferrin.
References
[1] https://en.wikipedia.org/wiki/Calreticulin