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Catechol-O-methyltransferase

Index Catechol-O-methyltransferase

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. [1]

53 relations: Adrenaline, Alzheimer's disease, Antidepressant, Arene substitution pattern, Biochemist, Catechol, Catechol estrogen, Catecholamine, Cognition, COMT inhibitor, Daniel R. Weinberger, Dihydroxyphenylethylene glycol, Dopamine, Dopamine transporter, Entacapone, Enzyme, Executive functions, Experience sampling method, Frontal lobe, Gene, Glossary of gene expression terms, Hepatotoxicity, Homovanillic acid, Julius Axelrod, L-DOPA, Metanephrine, Methionine, Methyl group, Monoamine oxidase, Neurotransmitter, Norepinephrine, Norepinephrine transporter, Normetanephrine, O-methyltransferase, Opicapone, Oxygen, Parkinson's disease, Pleiotropy, Prefrontal cortex, Rs4680, S-Adenosyl methionine, Schizophrenia, Single-nucleotide polymorphism, Sophia Frangou, Temporomandibular joint dysfunction, Tolcapone, Trait theory, Valine, Vanillylmandelic acid, 3,4-Dihydroxymandelic acid, ..., 3,4-Dihydroxyphenylacetic acid, 3-Methoxy-4-hydroxyphenylglycol, 3-Methoxytyramine. Expand index (3 more) »

Adrenaline

Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.

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Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Arene substitution pattern

Arene substitution patterns are part of organic chemistry IUPAC nomenclature and pinpoint the position of substituents other than hydrogen in relation to each other on an aromatic hydrocarbon.

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Biochemist

Biochemists are scientists that are trained in biochemistry.

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Catechol

Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C6H4(OH)2.

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Catechol estrogen

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure.

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Catecholamine

A catecholamine (CA) is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine.

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Cognition

Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

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COMT inhibitor

A COMT inhibitor is a drug that inhibits the action of catechol-O-methyl transferase.

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Daniel R. Weinberger

Daniel R. Weinberger is professor of psychiatry, neurology and neuroscience at Johns Hopkins University and Director and CEO of the Lieber Institute for Brain Development, which opened in 2011.

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Dihydroxyphenylethylene glycol

Dihydroxyphenylethylene glycol (DOPEG) is a metabolite of norepinephrine through monoamine oxidase.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Dopamine transporter

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.

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Entacapone

Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Executive functions

Executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals.

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Experience sampling method

The experience sampling method, also referred to as a daily diary method, or ecological momentary assessment (EMA), is an intensive longitudinal research methodology that involves asking participants to report on their thoughts, feelings, behaviors, and/or environment on multiple occasions over time.

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Frontal lobe

The frontal lobe, located at the front of the brain, is the largest of the four major lobes of the cerebral cortex in the mammalian brain.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glossary of gene expression terms

No description.

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

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Homovanillic acid

Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine.

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Julius Axelrod

Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist.

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L-DOPA

L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.

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Metanephrine

Metanephrine (metadrenaline) is a metabolite of epinephrine (adrenaline) created by action of catechol-O-methyl transferase on epinephrine.

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Methionine

Methionine (symbol Met or M) is an essential amino acid in humans.

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Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

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Monoamine oxidase

L-Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Norepinephrine transporter

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

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Normetanephrine

Normetanephrine is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine.

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O-methyltransferase

An O-methyltransferase (OMT) is a type of methyltransferase enzyme transferring a methyl group on a molecule.

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Opicapone

Opicapone is a pharmaceutical drug acting as a catechol-O-methyltransferase (COMT) inhibitor.

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Oxygen

Oxygen is a chemical element with symbol O and atomic number 8.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Pleiotropy

Pleiotropy (from Greek πλείων pleion, "more", and τρόπος tropos, "way") occurs when one gene influences two or more seemingly unrelated phenotypic traits.

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Prefrontal cortex

In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.

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Rs4680

In genetics, rs4680 (Val158Met) is a genetic variant.

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S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

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Schizophrenia

Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.

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Single-nucleotide polymorphism

A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

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Sophia Frangou

Sophia Frangou (Σοφία Φράγκου) is Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai where she heads the Psychosis Research Program.

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Temporomandibular joint dysfunction

Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).

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Tolcapone

Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD).

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Trait theory

In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.

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Valine

Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.

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Vanillylmandelic acid

Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine.

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3,4-Dihydroxymandelic acid

3,4-Dihydroxymandelic acid (DHMA, DOMA) is a metabolite of norepinephrine.

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3,4-Dihydroxyphenylacetic acid

3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.

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3-Methoxy-4-hydroxyphenylglycol

3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation.

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3-Methoxytyramine

3-Methoxytyramine (3-MT), also known as 3-methoxy-4-hydroxyphenethylamine, is a human trace amine that occurs as a metabolite of the neurotransmitter dopamine.

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Redirects here:

COMT, COMT (gene), COMT I, COMT II, Catechol O-methyl transferase, Catechol O-methyltransferase, Catechol methyltransferase, Catechol-O-Methyltransferase, Catechol-O-methyl transferase, Catechol-o-methyl transferase, Catechol-o-methyltransferase, Catecholamine O-methyltransferase, EC 2.1.1.6, HEL-S-98n, MB-COMT, O-methyl transferase, S-COMT, S-adenosyl-L-methionine:catechol O-methyltransferase, S-adenozil-L-metionin:catechol O-methyltransferase.

References

[1] https://en.wikipedia.org/wiki/Catechol-O-methyltransferase

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