Get it on Google Play
New! Download Unionpedia on your Android™ device!
Faster access than browser!


Index Catechol-O-methyltransferase

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. [1]

53 relations: Adrenaline, Alzheimer's disease, Antidepressant, Arene substitution pattern, Biochemist, Catechol, Catechol estrogen, Catecholamine, Cognition, COMT inhibitor, Daniel R. Weinberger, Dihydroxyphenylethylene glycol, Dopamine, Dopamine transporter, Entacapone, Enzyme, Executive functions, Experience sampling method, Frontal lobe, Gene, Glossary of gene expression terms, Hepatotoxicity, Homovanillic acid, Julius Axelrod, L-DOPA, Metanephrine, Methionine, Methyl group, Monoamine oxidase, Neurotransmitter, Norepinephrine, Norepinephrine transporter, Normetanephrine, O-methyltransferase, Opicapone, Oxygen, Parkinson's disease, Pleiotropy, Prefrontal cortex, Rs4680, S-Adenosyl methionine, Schizophrenia, Single-nucleotide polymorphism, Sophia Frangou, Temporomandibular joint dysfunction, Tolcapone, Trait theory, Valine, Vanillylmandelic acid, 3,4-Dihydroxymandelic acid, ..., 3,4-Dihydroxyphenylacetic acid, 3-Methoxy-4-hydroxyphenylglycol, 3-Methoxytyramine. Expand index (3 more) »


Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.

New!!: Catechol-O-methyltransferase and Adrenaline · See more »

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

New!!: Catechol-O-methyltransferase and Alzheimer's disease · See more »


Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

New!!: Catechol-O-methyltransferase and Antidepressant · See more »

Arene substitution pattern

Arene substitution patterns are part of organic chemistry IUPAC nomenclature and pinpoint the position of substituents other than hydrogen in relation to each other on an aromatic hydrocarbon.

New!!: Catechol-O-methyltransferase and Arene substitution pattern · See more »


Biochemists are scientists that are trained in biochemistry.

New!!: Catechol-O-methyltransferase and Biochemist · See more »


Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C6H4(OH)2.

New!!: Catechol-O-methyltransferase and Catechol · See more »

Catechol estrogen

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure.

New!!: Catechol-O-methyltransferase and Catechol estrogen · See more »


A catecholamine (CA) is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine.

New!!: Catechol-O-methyltransferase and Catecholamine · See more »


Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

New!!: Catechol-O-methyltransferase and Cognition · See more »

COMT inhibitor

A COMT inhibitor is a drug that inhibits the action of catechol-O-methyl transferase.

New!!: Catechol-O-methyltransferase and COMT inhibitor · See more »

Daniel R. Weinberger

Daniel R. Weinberger is professor of psychiatry, neurology and neuroscience at Johns Hopkins University and Director and CEO of the Lieber Institute for Brain Development, which opened in 2011.

New!!: Catechol-O-methyltransferase and Daniel R. Weinberger · See more »

Dihydroxyphenylethylene glycol

Dihydroxyphenylethylene glycol (DOPEG) is a metabolite of norepinephrine through monoamine oxidase.

New!!: Catechol-O-methyltransferase and Dihydroxyphenylethylene glycol · See more »


Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

New!!: Catechol-O-methyltransferase and Dopamine · See more »

Dopamine transporter

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.

New!!: Catechol-O-methyltransferase and Dopamine transporter · See more »


Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.

New!!: Catechol-O-methyltransferase and Entacapone · See more »


Enzymes are macromolecular biological catalysts.

New!!: Catechol-O-methyltransferase and Enzyme · See more »

Executive functions

Executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals.

New!!: Catechol-O-methyltransferase and Executive functions · See more »

Experience sampling method

The experience sampling method, also referred to as a daily diary method, or ecological momentary assessment (EMA), is an intensive longitudinal research methodology that involves asking participants to report on their thoughts, feelings, behaviors, and/or environment on multiple occasions over time.

New!!: Catechol-O-methyltransferase and Experience sampling method · See more »

Frontal lobe

The frontal lobe, located at the front of the brain, is the largest of the four major lobes of the cerebral cortex in the mammalian brain.

New!!: Catechol-O-methyltransferase and Frontal lobe · See more »


In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: Catechol-O-methyltransferase and Gene · See more »

Glossary of gene expression terms

No description.

New!!: Catechol-O-methyltransferase and Glossary of gene expression terms · See more »


Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

New!!: Catechol-O-methyltransferase and Hepatotoxicity · See more »

Homovanillic acid

Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine.

New!!: Catechol-O-methyltransferase and Homovanillic acid · See more »

Julius Axelrod

Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist.

New!!: Catechol-O-methyltransferase and Julius Axelrod · See more »


L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.

New!!: Catechol-O-methyltransferase and L-DOPA · See more »


Metanephrine (metadrenaline) is a metabolite of epinephrine (adrenaline) created by action of catechol-O-methyl transferase on epinephrine.

New!!: Catechol-O-methyltransferase and Metanephrine · See more »


Methionine (symbol Met or M) is an essential amino acid in humans.

New!!: Catechol-O-methyltransferase and Methionine · See more »

Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

New!!: Catechol-O-methyltransferase and Methyl group · See more »

Monoamine oxidase

L-Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines.

New!!: Catechol-O-methyltransferase and Monoamine oxidase · See more »


Neurotransmitters are endogenous chemicals that enable neurotransmission.

New!!: Catechol-O-methyltransferase and Neurotransmitter · See more »


Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

New!!: Catechol-O-methyltransferase and Norepinephrine · See more »

Norepinephrine transporter

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

New!!: Catechol-O-methyltransferase and Norepinephrine transporter · See more »


Normetanephrine is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine.

New!!: Catechol-O-methyltransferase and Normetanephrine · See more »


An O-methyltransferase (OMT) is a type of methyltransferase enzyme transferring a methyl group on a molecule.

New!!: Catechol-O-methyltransferase and O-methyltransferase · See more »


Opicapone is a pharmaceutical drug acting as a catechol-O-methyltransferase (COMT) inhibitor.

New!!: Catechol-O-methyltransferase and Opicapone · See more »


Oxygen is a chemical element with symbol O and atomic number 8.

New!!: Catechol-O-methyltransferase and Oxygen · See more »

Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

New!!: Catechol-O-methyltransferase and Parkinson's disease · See more »


Pleiotropy (from Greek πλείων pleion, "more", and τρόπος tropos, "way") occurs when one gene influences two or more seemingly unrelated phenotypic traits.

New!!: Catechol-O-methyltransferase and Pleiotropy · See more »

Prefrontal cortex

In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.

New!!: Catechol-O-methyltransferase and Prefrontal cortex · See more »


In genetics, rs4680 (Val158Met) is a genetic variant.

New!!: Catechol-O-methyltransferase and Rs4680 · See more »

S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

New!!: Catechol-O-methyltransferase and S-Adenosyl methionine · See more »


Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.

New!!: Catechol-O-methyltransferase and Schizophrenia · See more »

Single-nucleotide polymorphism

A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

New!!: Catechol-O-methyltransferase and Single-nucleotide polymorphism · See more »

Sophia Frangou

Sophia Frangou (Σοφία Φράγκου) is Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai where she heads the Psychosis Research Program.

New!!: Catechol-O-methyltransferase and Sophia Frangou · See more »

Temporomandibular joint dysfunction

Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).

New!!: Catechol-O-methyltransferase and Temporomandibular joint dysfunction · See more »


Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD).

New!!: Catechol-O-methyltransferase and Tolcapone · See more »

Trait theory

In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.

New!!: Catechol-O-methyltransferase and Trait theory · See more »


Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.

New!!: Catechol-O-methyltransferase and Valine · See more »

Vanillylmandelic acid

Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine.

New!!: Catechol-O-methyltransferase and Vanillylmandelic acid · See more »

3,4-Dihydroxymandelic acid

3,4-Dihydroxymandelic acid (DHMA, DOMA) is a metabolite of norepinephrine.

New!!: Catechol-O-methyltransferase and 3,4-Dihydroxymandelic acid · See more »

3,4-Dihydroxyphenylacetic acid

3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.

New!!: Catechol-O-methyltransferase and 3,4-Dihydroxyphenylacetic acid · See more »


3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation.

New!!: Catechol-O-methyltransferase and 3-Methoxy-4-hydroxyphenylglycol · See more »


3-Methoxytyramine (3-MT), also known as 3-methoxy-4-hydroxyphenethylamine, is a human trace amine that occurs as a metabolite of the neurotransmitter dopamine.

New!!: Catechol-O-methyltransferase and 3-Methoxytyramine · See more »

Redirects here:

COMT, COMT (gene), COMT I, COMT II, Catechol O-methyl transferase, Catechol O-methyltransferase, Catechol methyltransferase, Catechol-O-Methyltransferase, Catechol-O-methyl transferase, Catechol-o-methyl transferase, Catechol-o-methyltransferase, Catecholamine O-methyltransferase, EC, HEL-S-98n, MB-COMT, O-methyl transferase, S-COMT, S-adenosyl-L-methionine:catechol O-methyltransferase, S-adenozil-L-metionin:catechol O-methyltransferase.


[1] https://en.wikipedia.org/wiki/Catechol-O-methyltransferase

Hey! We are on Facebook now! »