Table of Contents
56 relations: Adrenaline, Alzheimer's disease, Antidepressant, Arene substitution pattern, Biochemist, Catechol, Catechol estrogen, Catechol-O-methyltransferase inhibitor, Catecholamine, Cognition, Dihydroxyphenylethylene glycol, Dopamine, Dopamine transporter, Entacapone, Enzyme, Executive functions, Experience sampling method, Frontal lobe, Gene, Glossary of cellular and molecular biology (0–L), Hepatotoxicity, Homovanillic acid, Julius Axelrod, L-DOPA, Meta-analysis, Metanephrine, Methionine, Methyl group, Monoamine oxidase, Neurotransmitter, Nitecapone, Norepinephrine, Norepinephrine transporter, Normetanephrine, O-methyltransferase, Opicapone, Oxygen, Parkinson's disease, Pleiotropy, Positive and Negative Syndrome Scale, Prefrontal cortex, Rs4680, S-Adenosyl methionine, Schizophrenia, Single-nucleotide polymorphism, Sophia Frangou, Temporomandibular joint dysfunction, Tolcapone, Trait theory, Valine, ... Expand index (6 more) »
- O-methylated natural phenols metabolism
- O-methylation
Adrenaline
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration).
See Catechol-O-methyltransferase and Adrenaline
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia.
See Catechol-O-methyltransferase and Alzheimer's disease
Antidepressant
Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.
See Catechol-O-methyltransferase and Antidepressant
Arene substitution pattern
Arene substitution patterns are part of organic chemistry IUPAC nomenclature and pinpoint the position of substituents other than hydrogen in relation to each other on an aromatic hydrocarbon.
See Catechol-O-methyltransferase and Arene substitution pattern
Biochemist
Biochemists are scientists who are trained in biochemistry.
See Catechol-O-methyltransferase and Biochemist
Catechol
Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula.
See Catechol-O-methyltransferase and Catechol
Catechol estrogen
A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure.
See Catechol-O-methyltransferase and Catechol estrogen
Catechol-O-methyltransferase inhibitor
A catechol-O-methyltransferase (COMT) inhibitor is a drug that inhibits the enzyme catechol-''O''-methyltransferase.
See Catechol-O-methyltransferase and Catechol-O-methyltransferase inhibitor
Catecholamine
A catecholamine (abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine.
See Catechol-O-methyltransferase and Catecholamine
Cognition
Cognition is the "mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".
See Catechol-O-methyltransferase and Cognition
Dihydroxyphenylethylene glycol
Dihydroxyphenylethylene glycol (DOPEG) is a metabolite of norepinephrine through monoamine oxidase.
See Catechol-O-methyltransferase and Dihydroxyphenylethylene glycol
Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.
See Catechol-O-methyltransferase and Dopamine
Dopamine transporter
The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
See Catechol-O-methyltransferase and Dopamine transporter
Entacapone
Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.
See Catechol-O-methyltransferase and Entacapone
Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
See Catechol-O-methyltransferase and Enzyme
Executive functions
In cognitive science and neuropsychology, executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals.
See Catechol-O-methyltransferase and Executive functions
Experience sampling method
The experience sampling method (ESM), also referred to as a daily diary method, or ecological momentary assessment (EMA), is an intensive longitudinal research methodology that involves asking participants to report on their thoughts, feelings, behaviors, and/or environment on multiple occasions over time.
See Catechol-O-methyltransferase and Experience sampling method
Frontal lobe
The frontal lobe is the largest of the four major lobes of the brain in mammals, and is located at the front of each cerebral hemisphere (in front of the parietal lobe and the temporal lobe).
See Catechol-O-methyltransferase and Frontal lobe
Gene
In biology, the word gene has two meanings.
See Catechol-O-methyltransferase and Gene
Glossary of cellular and molecular biology (0–L)
This glossary of cellular and molecular biology is a list of definitions of terms and concepts commonly used in the study of cell biology, molecular biology, and related disciplines, including genetics, biochemistry, and microbiology.
See Catechol-O-methyltransferase and Glossary of cellular and molecular biology (0–L)
Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
See Catechol-O-methyltransferase and Hepatotoxicity
Homovanillic acid
Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine.
See Catechol-O-methyltransferase and Homovanillic acid
Julius Axelrod
Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist.
See Catechol-O-methyltransferase and Julius Axelrod
L-DOPA
-DOPA, also known as levodopa and -3,4-dihydroxyphenylalanine, is made and used as part of the normal biology of some plants and animals, including humans.
See Catechol-O-methyltransferase and L-DOPA
Meta-analysis
Meta-analysis is the statistical combination of the results of multiple studies addressing a similar research question.
See Catechol-O-methyltransferase and Meta-analysis
Metanephrine
Metanephrine, also known as metadrenaline, is a metabolite of epinephrine (also known as adrenaline) created by action of catechol-O-methyl transferase on epinephrine.
See Catechol-O-methyltransferase and Metanephrine
Methionine
Methionine (symbol Met or M) is an essential amino acid in humans.
See Catechol-O-methyltransferase and Methionine
Methyl group
In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula). In formulas, the group is often abbreviated as Me.
See Catechol-O-methyltransferase and Methyl group
Monoamine oxidase
Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group.
See Catechol-O-methyltransferase and Monoamine oxidase
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
See Catechol-O-methyltransferase and Neurotransmitter
Nitecapone
Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol ''O''-methyl transferase (COMT).
See Catechol-O-methyltransferase and Nitecapone
Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator.
See Catechol-O-methyltransferase and Norepinephrine
Norepinephrine transporter
The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.
See Catechol-O-methyltransferase and Norepinephrine transporter
Normetanephrine
Normetanephrine, also called normetadrenaline, is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine.
See Catechol-O-methyltransferase and Normetanephrine
O-methyltransferase
An O-methyltransferase (OMT) is a type of methyltransferase enzyme transferring a methyl group on a molecule. Catechol-O-methyltransferase and o-methyltransferase are o-methylation.
See Catechol-O-methyltransferase and O-methyltransferase
Opicapone
Opicapone, sold under the brand name Ongentys, is a medication which is administered together with levodopa in people with Parkinson's disease.
See Catechol-O-methyltransferase and Opicapone
Oxygen
Oxygen is a chemical element; it has symbol O and atomic number 8.
See Catechol-O-methyltransferase and Oxygen
Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.
See Catechol-O-methyltransferase and Parkinson's disease
Pleiotropy
Pleiotropy (from Greek, 'more', and, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits.
See Catechol-O-methyltransferase and Pleiotropy
Positive and Negative Syndrome Scale
The Positive and Negative Syndrome Scale (PANSS) is a medical scale used for measuring symptom severity of patients with schizophrenia.
See Catechol-O-methyltransferase and Positive and Negative Syndrome Scale
Prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex.
See Catechol-O-methyltransferase and Prefrontal cortex
Rs4680
In genetics, rs4680 (Val158Met) is a genetic variant.
See Catechol-O-methyltransferase and Rs4680
S-Adenosyl methionine
S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.
See Catechol-O-methyltransferase and S-Adenosyl methionine
Schizophrenia
Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.
See Catechol-O-methyltransferase and Schizophrenia
Single-nucleotide polymorphism
In genetics and bioinformatics, a single-nucleotide polymorphism (SNP; plural SNPs) is a germline substitution of a single nucleotide at a specific position in the genome.
See Catechol-O-methyltransferase and Single-nucleotide polymorphism
Sophia Frangou
Sophia Frangou (Σοφία Φράγκου) is a professor of psychiatry at the Icahn School of Medicine at Mount Sinai where she heads the Psychosis Research Program.
See Catechol-O-methyltransferase and Sophia Frangou
Temporomandibular joint dysfunction
Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).
See Catechol-O-methyltransferase and Temporomandibular joint dysfunction
Tolcapone
Tolcapone, sold under the brand name Tasmar, is a medication used to treat Parkinson's disease (PD).
See Catechol-O-methyltransferase and Tolcapone
Trait theory
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.
See Catechol-O-methyltransferase and Trait theory
Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.
See Catechol-O-methyltransferase and Valine
Vanillylmandelic acid
Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines (epinephrine, and norepinephrine).
See Catechol-O-methyltransferase and Vanillylmandelic acid
3,4-Dihydroxymandelic acid
3,4-Dihydroxymandelic acid (DHMA, DOMA) is a metabolite of norepinephrine.
See Catechol-O-methyltransferase and 3,4-Dihydroxymandelic acid
3,4-Dihydroxyphenylacetic acid
3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.
See Catechol-O-methyltransferase and 3,4-Dihydroxyphenylacetic acid
3-Methoxy-4-hydroxyphenylglycol
3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation.
See Catechol-O-methyltransferase and 3-Methoxy-4-hydroxyphenylglycol
3-Methoxytyramine
3-Methoxytyramine (3-MT), also known as 3-methoxy-4-hydroxyphenethylamine, is a human trace amine that occurs as a metabolite of the neurotransmitter dopamine.
See Catechol-O-methyltransferase and 3-Methoxytyramine
3-O-Methyldopa
3-O-Methyldopa (3-OMD) is one of the most important metabolites of L-DOPA, a drug used in the treatment of the Parkinson's disease.
See Catechol-O-methyltransferase and 3-O-Methyldopa
See also
O-methylated natural phenols metabolism
- Catechol-O-methyltransferase
- Phenol O-methyltransferase
O-methylation
- 2'-O-methylation
- Caffeoyl-CoA O-methyltransferase
- Catechol-O-methyltransferase
- Methoxy group
- O-methylated flavonoid
- O-methyltransferase
References
Also known as COMT, COMT (gene), COMT I, COMT II, Catechol O-methyl transferase, Catechol O-methyltransferase, Catechol methyltransferase, Catechol-O-methyl transferase, Catecholamine O-methyltransferase, EC 2.1.1.6, HEL-S-98n, MB-COMT, O-methyl transferase, S-COMT, S-adenosyl-L-methionine:catechol O-methyltransferase, S-adenozil-L-metionin:catechol O-methyltransferase.