53 relations: Adrenaline, Alzheimer's disease, Antidepressant, Arene substitution pattern, Biochemist, Catechol, Catechol estrogen, Catecholamine, Cognition, COMT inhibitor, Daniel R. Weinberger, Dihydroxyphenylethylene glycol, Dopamine, Dopamine transporter, Entacapone, Enzyme, Executive functions, Experience sampling method, Frontal lobe, Gene, Glossary of gene expression terms, Hepatotoxicity, Homovanillic acid, Julius Axelrod, L-DOPA, Metanephrine, Methionine, Methyl group, Monoamine oxidase, Neurotransmitter, Norepinephrine, Norepinephrine transporter, Normetanephrine, O-methyltransferase, Opicapone, Oxygen, Parkinson's disease, Pleiotropy, Prefrontal cortex, Rs4680, S-Adenosyl methionine, Schizophrenia, Single-nucleotide polymorphism, Sophia Frangou, Temporomandibular joint dysfunction, Tolcapone, Trait theory, Valine, Vanillylmandelic acid, 3,4-Dihydroxymandelic acid, ..., 3,4-Dihydroxyphenylacetic acid, 3-Methoxy-4-hydroxyphenylglycol, 3-Methoxytyramine. Expand index (3 more) » « Shrink index
Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
Arene substitution patterns are part of organic chemistry IUPAC nomenclature and pinpoint the position of substituents other than hydrogen in relation to each other on an aromatic hydrocarbon.
Biochemists are scientists that are trained in biochemistry.
Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C6H4(OH)2.
A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure.
A catecholamine (CA) is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine.
Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".
A COMT inhibitor is a drug that inhibits the action of catechol-O-methyl transferase.
Daniel R. Weinberger is professor of psychiatry, neurology and neuroscience at Johns Hopkins University and Director and CEO of the Lieber Institute for Brain Development, which opened in 2011.
Dihydroxyphenylethylene glycol (DOPEG) is a metabolite of norepinephrine through monoamine oxidase.
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.
Enzymes are macromolecular biological catalysts.
Executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals.
The experience sampling method, also referred to as a daily diary method, or ecological momentary assessment (EMA), is an intensive longitudinal research methodology that involves asking participants to report on their thoughts, feelings, behaviors, and/or environment on multiple occasions over time.
The frontal lobe, located at the front of the brain, is the largest of the four major lobes of the cerebral cortex in the mammalian brain.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine.
Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist.
L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.
Metanephrine (metadrenaline) is a metabolite of epinephrine (adrenaline) created by action of catechol-O-methyl transferase on epinephrine.
Methionine (symbol Met or M) is an essential amino acid in humans.
A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.
L-Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines.
Neurotransmitters are endogenous chemicals that enable neurotransmission.
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
Normetanephrine is a metabolite of norepinephrine created by action of catechol-O-methyl transferase on norepinephrine.
An O-methyltransferase (OMT) is a type of methyltransferase enzyme transferring a methyl group on a molecule.
Opicapone is a pharmaceutical drug acting as a catechol-O-methyltransferase (COMT) inhibitor.
Oxygen is a chemical element with symbol O and atomic number 8.
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
Pleiotropy (from Greek πλείων pleion, "more", and τρόπος tropos, "way") occurs when one gene influences two or more seemingly unrelated phenotypic traits.
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
In genetics, rs4680 (Val158Met) is a genetic variant.
S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).
Sophia Frangou (Σοφία Φράγκου) is Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai where she heads the Psychosis Research Program.
Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull).
Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD).
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.
Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine.
3,4-Dihydroxymandelic acid (DHMA, DOMA) is a metabolite of norepinephrine.
3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.
3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) is a metabolite of norepinephrine degradation.
3-Methoxytyramine (3-MT), also known as 3-methoxy-4-hydroxyphenethylamine, is a human trace amine that occurs as a metabolite of the neurotransmitter dopamine.
COMT, COMT (gene), COMT I, COMT II, Catechol O-methyl transferase, Catechol O-methyltransferase, Catechol methyltransferase, Catechol-O-Methyltransferase, Catechol-O-methyl transferase, Catechol-o-methyl transferase, Catechol-o-methyltransferase, Catecholamine O-methyltransferase, EC 22.214.171.124, HEL-S-98n, MB-COMT, O-methyl transferase, S-COMT, S-adenosyl-L-methionine:catechol O-methyltransferase, S-adenozil-L-metionin:catechol O-methyltransferase.