Catechol estrogen

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. ^[1]

Adrenaline

Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). Catechol estrogen and Adrenaline are human metabolites.

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Antiestrogen

Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body.

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Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

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Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

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Catechol

Catechol, also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula.

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Catechol-O-methyltransferase

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.

See Catechol estrogen and Catechol-O-methyltransferase

Catecholamine

A catecholamine (abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine.

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Chemical structure

A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds.

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Competitive inhibition

Competitive inhibition is interruption of a chemical pathway owing to one chemical substance inhibiting the effect of another by competing with it for binding or bonding.

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Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.

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Drug metabolism

Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

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Enzyme inhibitor

An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.

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Epiestriol

Epiestriol (brand names Actriol, Arcagynil, Klimadoral), or epioestriol, also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is a minor and weak endogenous estrogen, and the 16β-epimer of estriol (which is 16α-hydroxy-17β-estradiol). Catechol estrogen and Epiestriol are Estranes and estrogens.

See Catechol estrogen and Epiestriol

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Catechol estrogen and Estradiol are Estranes and estrogens.

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Estriol

Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone. Catechol estrogen and Estriol are Estranes and estrogens.

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Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Catechol estrogen and Estrogen are Estranes and estrogens.

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Estrogen conjugate

An estrogen conjugate is a conjugate of an endogenous estrogen. Catechol estrogen and estrogen conjugate are Estranes, estrogens, human metabolites and steroid hormones.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. Catechol estrogen and Estrone are Estranes and estrogens.

See Catechol estrogen and Estrone

Lipoidal estradiol

Lipoidal estradiol (LE2) is the variety of endogenous C17β long-chain fatty acid esters of estradiol which are formed as metabolites of estradiol. Catechol estrogen and Lipoidal estradiol are Estranes, estrogens and human metabolites.

See Catechol estrogen and Lipoidal estradiol

Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Methoxy group

In organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen.

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator.

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Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).

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Quinone

The quinones are a class of organic compounds that are formally "derived from aromatic compounds by conversion of an even number of –CH.

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Reactive oxygen species

In chemistry and biology, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen, water, and hydrogen peroxide.

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Redox

Redox (reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change.

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Semiquinone

Semiquinones (or ubisemiquinones, if their origin is ubiquinone) are free radicals resulting from the removal of one hydrogen atom with its electron during the process of dehydrogenation of a hydroquinone, such as hydroquinone itself or catechol, to a quinone or alternatively the addition of a single hydrogen atom with its electron to a quinone.

See Catechol estrogen and Semiquinone

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Substrate (chemistry)

In chemistry, the term substrate is highly context-dependent.

See Catechol estrogen and Substrate (chemistry)

Tyrosine hydroxylase

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA).

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Uterus

The uterus (from Latin uterus,: uteri) or womb is the organ in the reproductive system of most female mammals, including humans, that accommodates the embryonic and fetal development of one or more embryos until birth.

See Catechol estrogen and Uterus

16α-Hydroxyestrone

16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-triene-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol. Catechol estrogen and 16α-Hydroxyestrone are Estranes, estrogens and human metabolites.

See Catechol estrogen and 16α-Hydroxyestrone

2-Hydroxyestradiol

2-Hydroxyestradiol (2-OHE2), also known as estra-1,3,5(10)-triene-2,3,17β-triol, is an endogenous steroid, catechol estrogen, and metabolite of estradiol, as well as a positional isomer of estriol. Catechol estrogen and 2-Hydroxyestradiol are catechol-O-methyltransferase inhibitors, Estranes, estrogens, human metabolites and steroid hormones.

See Catechol estrogen and 2-Hydroxyestradiol

2-Hydroxyestriol

2-Hydroxyestriol, also known as estra-1,3,5(10)-triene-2,3,16α,17β-tetrol, is an endogenous catechol estrogen and metabolite of estriol. Catechol estrogen and 2-Hydroxyestriol are Estranes and human metabolites.

See Catechol estrogen and 2-Hydroxyestriol

2-Hydroxyestrone

2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite of estrone and estradiol. Catechol estrogen and 2-Hydroxyestrone are catechol-O-methyltransferase inhibitors, Estranes and human metabolites.

See Catechol estrogen and 2-Hydroxyestrone

2-Methoxyestradiol

2-Methoxyestradiol (2-ME2, 2-MeO-E2) is a natural metabolite of estradiol and 2-hydroxyestradiol (2-OHE2). Catechol estrogen and 2-Methoxyestradiol are Estranes and human metabolites.

See Catechol estrogen and 2-Methoxyestradiol

4-Hydroxyestradiol

4-Hydroxyestradiol (4-OHE2), also known as estra-1,3,5(10)-triene-3,4,17β-triol, is an endogenous, naturally occurring catechol estrogen and a minor metabolite of estradiol. Catechol estrogen and 4-Hydroxyestradiol are Estranes, estrogens and human metabolites.

See Catechol estrogen and 4-Hydroxyestradiol

4-Hydroxyestriol

4-Hydroxyestriol, also known as estra-1,3,5(10)-triene-3,4,16α,17β-tetrol, is an endogenous catechol estrogen and metabolite of estriol. Catechol estrogen and 4-Hydroxyestriol are Estranes, estrogens and human metabolites.

See Catechol estrogen and 4-Hydroxyestriol

4-Hydroxyestrone

4-Hydroxyestrone (4-OHE1), also known as estra-1,3,5(10)-triene-3,4-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a minor metabolite of estrone and estradiol. Catechol estrogen and 4-Hydroxyestrone are Estranes, estrogens and human metabolites.

See Catechol estrogen and 4-Hydroxyestrone

4-Methoxyestrone

4-Methoxyestrone (4-ME1) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestrone. Catechol estrogen and 4-Methoxyestrone are Estranes, estrogens, human metabolites and steroid hormones.

See Catechol estrogen and 4-Methoxyestrone

References

[1] https://en.wikipedia.org/wiki/Catechol_estrogen

Also known as Catechol estrogens, Catecholestrogen, Catecholestrogens.

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Catechol estrogen

Table of Contents

See also

Catechol-O-methyltransferase inhibitors

Steroid hormones

References