Cbl TKB domain

In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. ^[1]

9 relations: CBL (gene), EF hand, Molecular binding, N-terminus, Protein domain, SH2 domain, Signal transducing adaptor protein, Tyrosine, Tyrosine kinase.

CBL (gene)

Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination.

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EF hand

The EF hand is a helix-loop-helix structural domain or motif found in a large family of calcium-binding proteins.

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Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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SH2 domain

The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.

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Signal transducing adaptor protein

Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway.

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Tyrosine

Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

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Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.

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References

[1] https://en.wikipedia.org/wiki/Cbl_TKB_domain

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