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12 relations: CD137, CD4, CD8, Dendritic cell, Immune checkpoint, Inflammation, Protein–protein interaction, T cell, TRAF2, Tumor necrosis factor superfamily, Urelumab, 4-1BB ligand.
CD137
CD137 is a member of the tumor necrosis factor (TNF) receptor family.
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CD4
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
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CD8
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR).
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Dendritic cell
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.
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Immune checkpoint
Immune checkpoints are regulators of the immune system.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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TRAF2
TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.
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Tumor necrosis factor superfamily
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers.
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Urelumab
Urelumab (BMS-663513 or anti-4-1BB antibody) is a fully human IgG4 monoclonal antibody developed by Bristol-Myers Squibb for the treatment of cancer and solid tumors.
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4-1BB ligand
4-1BB is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, expressed on activated T Lymphocytes.
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4-1bb, Cd137 antigens, TNFRSF9, TNFRSF9 (gene), Utomilumab.
