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15 relations: Abituzumab, Alpha-v beta-3, Alpha-v beta-5, Cluster of differentiation, Colorectal cancer, CYR61, Fibronectin, Gene, Integrin, Intetumumab, Monoclonal antibody, Osteopontin, Protein, Transforming growth factor beta, Vitronectin.
Abituzumab
Abituzumab is a humanized IgG2 monoclonal antibody (mAb) targeted at CD51 (an integrin) currently in development by Merck KGaA Darmstadt, Germany in an attempt to prevent bone lesion metastases in castration-resistant prostate cancer.
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Alpha-v beta-3
αVβ3 is a type of integrin that is a receptor for vitronectin.
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Alpha-v beta-5
αVβ5 is a type of integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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CYR61
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene.
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Fibronectin
Fibronectin is a high-molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Integrin
Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion.
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Intetumumab
Intetumumab is a human monoclonal antibody that was being studied for the treatment of solid tumors.
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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Osteopontin
Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Transforming growth factor beta
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.
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Vitronectin
Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is abundantly found in serum, the extracellular matrix and bone.
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CD51, Cd51, ITGAV, ITGAV (gene), Integrin alpha-V, MSK8, Msk8, VNRA, Vnra, Αv integrin, Αv integrins.
