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Centre for Applied Genomics

Index Centre for Applied Genomics

The Centre for Applied Genomics is a genome centre in the Research Institute of The Hospital for Sick Children, and is affiliated with the University of Toronto. [1]

81 relations: Abdallah Daar, Affymetrix, Agilent Technologies, Applied Biosystems, Autism spectrum, Bacterial artificial chromosome, Biodiversity, Bioinformatics, Canada Foundation for Innovation, Canadian Institutes of Health Research, Cancer stem cell, CDNA library, Cell (biology), Cell culture, Centre for Addiction and Mental Health, Chromosome 7, Complementary DNA, Copy-number variation, Cystic fibrosis, Dalla Lana School of Public Health, Diabetes mellitus type 1, DNA microarray, DNA sequencing, Epidemiology, Epigenetics, Epilepsy, Ex officio member, Fibroblast, Fluorescence in situ hybridization, Genetic linkage, Genetics, Genomics, Genotyping, Heteroduplex, High-performance liquid chromatography, Human genome, Illumina (company), Information retrieval, J. Craig Venter Institute, Karyotype, Laboratory information management system, Lap-Chee Tsui, Life Technologies (Thermo Fisher Scientific), Locus (genetics), Mark Daly (scientist), MaRS Discovery District, Medulloblastoma, Metabolic pathway, Methylation, Microarray, ..., Microsatellite, Ministry of Research, Innovation and Science, Mount Sinai Hospital (Toronto), Mouse, Nuclear DNA, Nucleobase, Oligonucleotide, Ottawa Hospital Research Institute, Population genetics, Power (statistics), PubMed, Real-time polymerase chain reaction, Rett syndrome, Roche Diagnostics, Saliva, Sanger sequencing, Software, Stanford University, Stem cell, Stephen W. Scherer, Structural biology, TaqMan, The Hospital for Sick Children, Tissue (biology), Toronto, University of Toronto, University of Toronto Mississauga, White blood cell, Whitehead Institute, Williams syndrome, 454 Life Sciences. Expand index (31 more) »

Abdallah Daar

Dr.

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Affymetrix

Affymetrix, Inc. was an American company that manufactured DNA microarrays; it was based in Santa Clara, California, United States.

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Agilent Technologies

Agilent Technologies is an American public research, development and manufacturing company established in 1999 as a spin-off from Hewlett-Packard.

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Applied Biosystems

Applied Biosystems is one of the various brands under the Life Technologies brand of Thermo Fisher Scientific corporation.

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Autism spectrum

Autism spectrum, also known as autism spectrum disorder (ASD), is a range of conditions classified as neurodevelopmental disorders.

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Bacterial artificial chromosome

A bacterial artificial chromosome (BAC) is a DNA construct, based on a functional fertility plasmid (or F-plasmid), used for transforming and cloning in bacteria, usually E. coli.

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Biodiversity

Biodiversity, a portmanteau of biological (life) and diversity, generally refers to the variety and variability of life on Earth.

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Bioinformatics

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data.

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Canada Foundation for Innovation

The Canada Foundation for Innovation (CFI; Fondation canadienne pour l’innovation, FCI) is an independent not-for-profit organization that invests in research facilities and equipment in Canada’s universities, colleges, research hospitals, and non-profit research institutions.

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Canadian Institutes of Health Research

Canadian Institutes of Health Research (CIHR, Instituts de recherche en santé du Canada) is the major federal agency responsible for funding health and medical research in Canada.

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Cancer stem cell

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample.

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CDNA library

A cDNA library is a combination of cloned cDNA (complementary DNA) fragments inserted into a collection of host cells, which together constitute some portion of the transcriptome of the organism and are stored as a "library".

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell culture

Cell culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.

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Centre for Addiction and Mental Health

The Centre for Addiction and Mental Health (CAMH; Centre de toxicomanie et de santé mentale) is a mental health teaching hospital in with central facilities located in Toronto and 10 community locations throughout the province of Ontario, Canada.

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Chromosome 7

Chromosome 7 is one of the 23 pairs of chromosomes in humans.

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Complementary DNA

In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.

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Copy-number variation

Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.

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Cystic fibrosis

Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine.

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Dalla Lana School of Public Health

Dalla Lana School of Public Health is the school of public health at the University of Toronto.

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Diabetes mellitus type 1

Diabetes mellitus type 1, also known as type 1 diabetes, is a form of diabetes mellitus in which not enough insulin is produced.

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DNA microarray

A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface.

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DNA sequencing

DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule.

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Epidemiology

Epidemiology is the study and analysis of the distribution (who, when, and where) and determinants of health and disease conditions in defined populations.

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Epigenetics

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

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Epilepsy

Epilepsy is a group of neurological disorders characterized by epileptic seizures.

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Ex officio member

An ex officio member is a member of a body (a board, committee, council, etc.) who is part of it by virtue of holding another office.

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Fibroblast

A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.

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Fluorescence in situ hybridization

Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.

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Genetic linkage

Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.

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Genetics

Genetics is the study of genes, genetic variation, and heredity in living organisms.

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Genomics

Genomics is an interdisciplinary field of science focusing on the structure, function, evolution, mapping, and editing of genomes.

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Genotyping

Genotyping is the process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence.

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Heteroduplex

A heteroduplex is a double-stranded (duplex) molecule of nucleic acid originated through the genetic recombination of single complementary strands derived from different sources, such as from different homologous chromosomes or even from different organisms.

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High-performance liquid chromatography

High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture.

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Human genome

The human genome is the complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.

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Illumina (company)

Illumina, Inc. is an American company incorporated in April 1998 that develops, manufactures and markets integrated systems for the analysis of genetic variation and biological function.

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Information retrieval

Information retrieval (IR) is the activity of obtaining information system resources relevant to an information need from a collection of information resources.

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J. Craig Venter Institute

The J. Craig Venter Institute (JCVI) is a non-profit genomics research institute founded by J. Craig Venter, Ph.D. in October 2006.

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Karyotype

A karyotype is the number and appearance of chromosomes in the nucleus of a eukaryotic cell.

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Laboratory information management system

A laboratory information management system (LIMS), sometimes referred to as a laboratory information system (LIS) or laboratory management system (LMS), is a software-based solution with features that support a modern laboratory's operations.

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Lap-Chee Tsui

Professor Lap-Chee Tsui, GBM, OC, O.Ont, JP (born 21 December 1950) is a Chinese-born Canadian geneticist and served as the 14th Vice-Chancellor and President of the University of Hong Kong.

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Life Technologies (Thermo Fisher Scientific)

Life Technologies Corporation was a biotech company founded in November 2008 through a US$6.7 billion merger of Invitrogen Corporation and Applied Biosystems Inc.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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Mark Daly (scientist)

Mark Joseph Daly is a Professor of Genetics at Harvard Medical School, Chief of the Analytic and Translational Genetic Unit at Massachusetts General Hospital, and a member of the Broad Institute of MIT and Harvard.

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MaRS Discovery District

MaRS Discovery District is a not-for-profit corporation founded in Toronto, Ontario, Canada in 2000.

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Medulloblastoma

Medulloblastoma is the most common type of pediatric malignant primary brain tumor (cancer), originating in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa.

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Metabolic pathway

In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell.

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Methylation

In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.

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Microarray

A microarray is a multiplex lab-on-a-chip.

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Microsatellite

A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 1–6 or more base pairs) are repeated, typically 5–50 times.

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Ministry of Research, Innovation and Science

The Ministry of Research, Innovation and Science is a government ministry of the Province of Ontario.

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Mount Sinai Hospital (Toronto)

Mount Sinai Hospital (MSH) is a hospital in Toronto, Ontario, Canada.

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Mouse

A mouse (Mus), plural mice, is a small rodent characteristically having a pointed snout, small rounded ears, a body-length scaly tail and a high breeding rate.

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Nuclear DNA

Nuclear DNA, or nuclear deoxyribonucleic acid (nDNA), is the DNA contained within the nucleus of a eukaryotic organism.

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Nucleobase

Nucleobases, also known as nitrogenous bases or often simply bases, are nitrogen-containing biological compounds that form nucleosides, which in turn are components of nucleotides, with all of these monomers constituting the basic building blocks of nucleic acids.

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Oligonucleotide

Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.

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Ottawa Hospital Research Institute

The Ottawa Hospital Research Institute (OHRI), formerly Ottawa Health Research Institute, is a non-profit academic health research institute located in the city of Ottawa.

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Population genetics

Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology.

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Power (statistics)

The power of a binary hypothesis test is the probability that the test correctly rejects the null hypothesis (H0) when a specific alternative hypothesis (H1) is true.

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PubMed

PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics.

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Real-time polymerase chain reaction

A real-time polymerase chain reaction (Real-Time PCR), also known as quantitative polymerase chain reaction (qPCR), is a laboratory technique of molecular biology based on the polymerase chain reaction (PCR).

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Rett syndrome

Rett syndrome (RTT) is a genetic brain disorder which typically becomes apparent after 6 to 18 months of age in females.

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Roche Diagnostics

Roche Diagnostics is a diagnostic division of Hoffmann-La Roche which manufactures equipment and reagents for research and medical diagnostic applications.

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Saliva

Saliva is a watery substance formed in the mouths of animals, secreted by the salivary glands.

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Sanger sequencing

Sanger sequencing is a method of DNA sequencing first commercialized by Applied Biosystems, based on the selective incorporation of chain-terminating dideoxynucleotides by DNA polymerase during in vitro DNA replication.

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Software

Computer software, or simply software, is a generic term that refers to a collection of data or computer instructions that tell the computer how to work, in contrast to the physical hardware from which the system is built, that actually performs the work.

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Stanford University

Stanford University (officially Leland Stanford Junior University, colloquially the Farm) is a private research university in Stanford, California.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Stephen W. Scherer

Stephen Wayne "Steve" Scherer (born January 5, 1964) is a Canadian scientist who studies genetic variation in human disease.

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Structural biology

Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules (especially proteins, made up of amino acids, and RNA or DNA, made up of nucleic acids), how they acquire the structures they have, and how alterations in their structures affect their function.

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TaqMan

TaqMan probes are hydrolysis probes that are designed to increase the specificity of quantitative PCR.

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The Hospital for Sick Children

The Hospital for Sick Children, corporately branded as SickKids, is a children's hospital and teaching hospital located on University Avenue in Toronto, Ontario, Canada.

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Tissue (biology)

In biology, tissue is a cellular organizational level between cells and a complete organ.

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Toronto

Toronto is the capital city of the province of Ontario and the largest city in Canada by population, with 2,731,571 residents in 2016.

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University of Toronto

The University of Toronto (U of T, UToronto, or Toronto) is a public research university in Toronto, Ontario, Canada on the grounds that surround Queen's Park.

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University of Toronto Mississauga

The University of Toronto Mississauga, commonly known by its initials UTM, is a satellite campus of the University of Toronto located in the neighbouring city of Mississauga, Ontario, Canada.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Whitehead Institute

Founded in 1982, the Whitehead Institute for Biomedical Research is a non-profit research and teaching institution located in Cambridge, Massachusetts, United States.

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Williams syndrome

Williams syndrome (WS) is a genetic disorder that affects many parts of the body.

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454 Life Sciences

454 Life Sciences was a biotechnology company based in Branford, Connecticut that specialized in high-throughput DNA sequencing.

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Redirects here:

TCAG, The Centre for Applied Genomics.

References

[1] https://en.wikipedia.org/wiki/Centre_for_Applied_Genomics

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