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121 relations: Acetylcholine receptor, Acute lymphoblastic leukemia, Adoptive cell transfer, Allogenic succession, Alpha helix, Anaphylaxis, Antibody, Antigen, Aspartic acid, Autotransplantation, Axicabtagene ciloleucel, B cell, Breast cancer, Carbonic anhydrase 9, Carcinoembryonic antigen, Caspase, CD134, CD19, CD20, CD22, CD28, CD3 (immunology), CD30, CD33, CD44, Cerebral edema, Cervical cancer, Chimera (genetics), Chronic lymphocytic leukemia, Clinical Journal of Oncology Nursing, Colorectal cancer, Cyclophosphamide, Cytokine, Cytokine release syndrome, Cytomegalovirus, Cytotoxicity, Diffuse large B-cell lymphoma, Ectodomain, Endoplasmic reticulum, Epithelial cell adhesion molecule, Fludarabine, Fluorescein isothiocyanate, Folate receptor 1, Folate-binding protein, Follicular lymphoma, Fred Hutchinson Cancer Research Center, Gammaretrovirus, GD2, Gene therapy, Gideon Gross, ..., Glioblastoma, Glioma, Glutamate carboxypeptidase II, Glutamic acid, Glycine, Hematopoietic stem cell transplantation, HER2/neu, Hodgkin's lymphoma, Hydrophile, Hydrophobe, IL13RA2, Immunoglobulin E, Immunoglobulin light chain, Immunoreceptor tyrosine-based activation motif, In vitro, In vivo, Insertional mutagenesis, Interferon, Interleukin, Interleukin 12, Juno Therapeutics, Kinase insert domain receptor, L1 (protein), Lentivirus, Leukemia, Leukocyte apheresis, Ligand, Lung cancer, Lymphoma, Lysine, Macrophage, MAGEA1, Major histocompatibility complex, Mantle cell lymphoma, Medulloblastoma, Melanoma, Mesothelin, Monoclonal antibody, MUC1, Myalgia, Myeloid-derived suppressor cell, National Hockey League, Neuroblastoma, NKG2D, Osteosarcoma, Ovarian cancer, Peptide, Peripheral blood mononuclear cell, Phosphoinositide 3-kinase, Prostate cancer, PSCA (gene), Receptor (biochemistry), Recombinant DNA, Renal cell carcinoma, Rhabdomyosarcoma, Serine, Signal peptide, Single-chain variable fragment, Solubility, Streptavidin, T cell, T-cell receptor, Tachycardia, Thymidine kinase, Tisagenlecleucel, Transmembrane domain, Tumor antigen, Tumor-associated glycoprotein 72, Tumor-associated macrophage, Weizmann Institute of Science, Zelig Eshhar. Expand index (71 more) »
Acetylcholine receptor
An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.
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Acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.
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Adoptive cell transfer
Adoptive cell transfer (ACT) is the transfer of cells into a patient.
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Allogenic succession
In ecology, allogenic succession is succession driven by the abiotic components of an ecosystem.
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Alpha helix
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
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Anaphylaxis
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Antigen
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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Autotransplantation
Autotransplantation is the transplantation of organs, tissues, or even particular proteins from one part of the body to another in the same person (auto- meaning "self" in Greek).
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Axicabtagene ciloleucel
Axicabtagene ciloleucel (KTE-C19, Axi-cel), marketed as Yescarta, is an adoptive cell transfer therapy for treating certain cases of large B-cell lymphoma.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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Carbonic anhydrase 9
Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.
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Carcinoembryonic antigen
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion.
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Caspase
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
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CD134
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28.
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CD19
B-lymphocyte antigen CD19, also known as CD19 molecule ('''C'''luster of '''D'''ifferentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.
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CD20
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity.
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CD22
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.
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CD28
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival.
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CD3 (immunology)
In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).
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CD30
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
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CD33
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.
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CD44
The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration.
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Cerebral edema
Cerebral edema is excess accumulation of fluid in the intracellular or extracellular spaces of the brain.
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Cervical cancer
Cervical cancer is a cancer arising from the cervix.
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Chimera (genetics)
A genetic chimerism or chimera (also spelled chimaera) is a single organism composed of cells with distinct genotypes.
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Chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).
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Clinical Journal of Oncology Nursing
The Clinical Journal of Oncology Nursing is a bimonthly peer-reviewed nursing journal covering oncology nursing.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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Cyclophosphamide
Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Cytokine release syndrome
Cytokine release syndrome is a form of systemic inflammatory response syndrome that arises as a complication of some diseases or infections, and is also an adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies.
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Cytomegalovirus
Cytomegalovirus (CMV) (from the Greek cyto-, "cell", and megalo-, "large") is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae.
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Cytotoxicity
Cytotoxicity is the quality of being toxic to cells.
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Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL or DLBL) is a cancer of B cells, a type of white blood cell responsible for producing antibodies.
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Ectodomain
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell).
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Endoplasmic reticulum
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
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Epithelial cell adhesion molecule
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia.
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Fludarabine
Fludarabine, sold under the brand name Fludara among others, is a chemotherapy medication used in the treatment of leukemia and lymphoma.
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Fluorescein isothiocyanate
Fluorescein isothiocyanate (FITC) is a derivative of fluorescein used in wide-ranging applications including flow cytometry.
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Folate receptor 1
Folate receptor alpha is a protein that in humans is encoded by the FOLR1 gene.
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Folate-binding protein
Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.
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Follicular lymphoma
Follicular lymphoma is a type of blood cancer.
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Fred Hutchinson Cancer Research Center
The Fred Hutchinson Cancer Research Center, also known as Fred Hutch or The Hutch, is a cancer research institute established in 1972 in Seattle, Washington.
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Gammaretrovirus
Gammaretrovirus is a genus in the retroviridae family.
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GD2
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans.
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Gene therapy
In the medicine field, gene therapy (also called human gene transfer) is the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease.
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Gideon Gross
Gideon Gross is an Israeli immunologist, inventor and farmer.
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Glioblastoma
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive cancer that begins within the brain.
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Glioma
A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
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Glutamate carboxypeptidase II
Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Glycine
Glycine (symbol Gly or G) is the amino acid that has a single hydrogen atom as its side chain.
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Hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.
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HER2/neu
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene.
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Hodgkin's lymphoma
Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.
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Hydrophile
A hydrophile is a molecule or other molecular entity that is attracted to water molecules and tends to be dissolved by water.
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Hydrophobe
In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.
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IL13RA2
Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.
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Immunoglobulin E
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals.
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Immunoglobulin light chain
The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin).
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Immunoreceptor tyrosine-based activation motif
An immunoreceptor tyrosine-based activation motif (ITAM) (in the antagonistic case ITIM, I for inhibition) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of certain cell surface proteins of the immune system.
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In vitro
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
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In vivo
Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.
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Insertional mutagenesis
In molecular biology, insertional mutagenesis is the creation of mutations of DNA by the addition of one or more base pairs.
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Interferon
Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells.
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Interleukin
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes).
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Interleukin 12
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.
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Juno Therapeutics
Juno Therapeutics is a biopharmaceutical company founded in 2013 through a collaboration of the Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and pediatrics partner Seattle Children's Research Institute.
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Kinase insert domain receptor
Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor.
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L1 (protein)
L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene.
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Lentivirus
Lentivirus (lente-, Latin for "slow") is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in the human and other mammalian species.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Leukocyte apheresis
Leukocyte apheresis is a medical device therapy (selective granulocyte/monocyte adsorptive apheresis; GMDN code: 47306) for the treatment of inflammation of the colon.
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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Lymphoma
Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).
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Lysine
Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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MAGEA1
Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.
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Major histocompatibility complex
The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.
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Mantle cell lymphoma
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma (NHL), comprising about 6% of NHL cases.
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Medulloblastoma
Medulloblastoma is the most common type of pediatric malignant primary brain tumor (cancer), originating in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa.
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Melanoma
Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.
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Mesothelin
Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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MUC1
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans.
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Myalgia
Myalgia, or muscle pain, is a symptom of many diseases and disorders.
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Myeloid-derived suppressor cell
MDSC (myeloid-derived suppressor cells) are a heterogenous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells).
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National Hockey League
The National Hockey League (NHL; Ligue nationale de hockey—LNH) is a professional ice hockey league in North America, currently comprising 31 teams: 24 in the United States and 7 in Canada.
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Neuroblastoma
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands, but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Occasionally, neuroblastoma may be due to a mutation inherited from a person's parents. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiation, chemotherapy, or stem cell transplantation. Low-risk disease in babies typically has a good outcome with surgery or simply observation. In high-risk disease, chances of long-term survival, however, are less than 40% despite aggressive treatment. Neuroblastoma is the most common cancer in babies and the third-most common cancer in children after leukemia and brain cancer. About one in every 7,000 children is affected at some time. About 90% of cases occur in children less than 5 years old and it is rare in adults. Of cancer deaths in children, about 15% are due to neuroblastoma. The disease was first described in the 1800s.
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NKG2D
NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors.
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Osteosarcoma
An osteosarcoma (OS) or osteogenic sarcoma (OGS) is a cancerous tumor in a bone.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Peripheral blood mononuclear cell
A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
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PSCA (gene)
Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Recombinant DNA
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.
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Renal cell carcinoma
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.
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Rhabdomyosarcoma
Rhabdomyosarcoma, or RMS, is an aggressive and highly malignant form of cancer that develops from skeletal (striated) muscle cells that have failed to fully differentiate.
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Serine
Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.
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Signal peptide
A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) present at the N-terminus of the majority of newly synthesized proteins that are destined towards the secretory pathway.
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Single-chain variable fragment
A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids.
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Solubility
Solubility is the property of a solid, liquid or gaseous chemical substance called solute to dissolve in a solid, liquid or gaseous solvent.
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Streptavidin
Streptavidin is a 52.8 kDa protein purified from the bacterium Streptomyces avidinii.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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T-cell receptor
The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
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Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
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Thymidine kinase
Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.21.
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Tisagenlecleucel
Tisagenlecleucel, marketed as Kymriah, is a treatment for B-cell acute lymphoblastic leukemia which uses the body's own T cells to fight cancer (adoptive cell transfer).
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Transmembrane domain
Transmembrane domain usually denotes a transmembrane segment of single alpha helix of a transmembrane protein.
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Tumor antigen
Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host.
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Tumor-associated glycoprotein 72
Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, lung, and pancreatic cancers.
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Tumor-associated macrophage
Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors.
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Weizmann Institute of Science
The Weizmann Institute of Science (מכון ויצמן למדע Machon Weizmann LeMada) is a public research university in Rehovot, Israel, established in 1934, 14 years before the State of Israel.
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Zelig Eshhar
Zelig Eshhar is an Israeli immunologist at the Weizmann Institute of Science and the Tel Aviv Sourasky Medical Center.
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Artificial T cell receptor, Artificial T cell receptors, Artificial t cell receptor, CAR T-cell therapy, CAR-T, CAR-T cell, CAR-T therapy, Chimeric Antigen Receptor, Chimeric T cell receptor, Chimeric antibody receptor, Engineered T-cell, Genetically engineered T cell.
References
[1] https://en.wikipedia.org/wiki/Chimeric_antigen_receptor
