33 relations: Acute myeloid leukemia, Anemia, Bone marrow, Catenin alpha-1, CDC25C, Cell nucleus, Chromosome 5, Cri du chat syndrome, Dysplasia, EGR1, Food and Drug Administration, Gene, Germline, Haploinsufficiency, Hyperplasia, Lenalidomide, Lobation, Locus (genetics), Macrocytic anemia, Megakaryocyte, Mir-145, MiR-146, Monosomy, Myelocyte, Myelodysplastic syndrome, Osteonectin, P53, Pathogenesis, Pure red cell aplasia, Thrombocythemia, Trisomy, Tumor suppressor, 40S ribosomal protein S14.
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen.
Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.
αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene.
M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
Chromosome 5 is one of the 23 pairs of chromosomes in humans.
Cri du chat syndrome, also known as chromosome 5p deletion syndrome, 5p− syndrome (pronounced "five P minus") or Lejeune's syndrome, is a rare genetic disorder due to chromosome deletion on chromosome 5.
Dysplasia (from Ancient Greek δυσ- dys-, "bad" or "difficult" and πλάσις plasis, "formation") is a term used in pathology to refer to an abnormality of development or an epithelial anomaly of growth and differentiation (epithelial dysplasia).
EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
In biology and genetics, the germline in a multicellular organism is the population of its bodily cells that are so differentiated or segregated that in the usual processes of reproduction they may pass on their genetic material to the progeny.
Haploinsufficiency is a mechanism of action to explain a phenotype when a diploid organism has lost one copy of a gene and is left with a single functional copy of that gene.
Hyperplasia (from ancient Greek ὑπέρ huper, "over" + πλάσις plasis, "formation"), or hypergenesis, is an increase in the amount of organic tissue that results from cell proliferation.
Lenalidomide (trade name Revlimid) is a derivative of thalidomide introduced in 2004.
Lobation is a characteristic of the cell nucleus of certain granulocytes, types of white blood cells, where the nucleus is segmented into two or more connected lobes.
A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).
The term macrocytic is from Greek words meaning "large cell".
A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting.
In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene.
miR-146 is a family of microRNA precursors found in mammals, including humans.
Monosomy is a form of aneuploidy with the presence of only one chromosome from a pair.
A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).
Myelodysplastic syndromes (MDS) are a group of cancers in which immature blood cells in the bone marrow do not mature and therefore do not become healthy blood cells.
Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene.
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
The pathogenesis of a disease is the biological mechanism (or mechanisms) that leads to the diseased state.
Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells.
Thrombocythemia (also thrombocytosis) is the presence of high platelet (thrombocyte) counts in the blood, and can be either primary (also termed essential thrombocythemia, and caused by a myeloproliferative disease) or secondary (also termed reactive).
A trisomy is a type of polysomy in which there are three instances of a particular chromosome, instead of the normal two.
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.
40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.