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65 relations: A549 cell, Adenocarcinoma of the lung, Adult T-cell leukemia/lymphoma, Albrecht Kossel, August Weismann, Beta thalassemia, C. H. Waddington, ChIA-PET, ChIP-sequencing, Chromatin, Chromatin immunoprecipitation, Chromosome, Chromosome territories, Crosslinking of DNA, DNA ligase, EcoRI, Eigendecomposition of a matrix, Emil Heitz, Enhancer (genetics), Epigenetics, Epigenetics & Chromatin, Estrogen, Euchromatin, Formaldehyde, Genetic testing, Globin, Harvard University, Heinrich Wilhelm Gottfried von Waldeyer-Hartz, HeLa, Hep G2, Heterochromatin, HindIII, Holoprosencephaly, Human Genome Project, Immortalised cell line, Inverse polymerase chain reaction, John T. Lis, K562 cells, Ligation (molecular biology), LNCaP, Locus (genetics), Mary F. Lyon, Microscopy, NCI-60, Nuclear organization, Nucleosome, Nucleotide, Oligonucleotide, PANC-1, Polymer, ..., Polymerase chain reaction, Primer (molecular biology), Prolactin, Promoter (genetics), Restriction enzyme, Rollin Hotchkiss, Sequence motif, Shotgun sequencing, T-47D, Theodor Boveri, Topologically associating domain, Transcriptional regulation, Walter Sutton, Walther Flemming, X-inactivation. Expand index (15 more) »
A549 cell
A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al.
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Adenocarcinoma of the lung
Adenocarcinoma of the lung (also known as pulmonary adenocarcinoma) is the most common type of lung cancer, and is characterized by distinct cellular and molecular features including gland and/or duct formation and/or production of significant amounts of mucus.
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Adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's own T-cells.
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Albrecht Kossel
Ludwig Karl Martin Leonhard Albrecht Kossel (16 September 1853 – 5 July 1927) was a German biochemist and pioneer in the study of genetics.
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August Weismann
August Friedrich Leopold Weismann (17 January 1834 – 5 November 1914) was a German evolutionary biologist.
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Beta thalassemia
Beta thalassemias (β thalassemias) are a group of inherited blood disorders.
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C. H. Waddington
Conrad Hal Waddington CBE FRS FRSE (8 November 1905 – 26 September 1975) was a British developmental biologist, paleontologist, geneticist, embryologist and philosopher who laid the foundations for systems biology, epigenetics, and evolutionary developmental biology.
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ChIA-PET
Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET) is a technique that incorporates chromatin immunoprecipitation (ChIP)-based enrichment, chromatin proximity ligation, Paired-End Tags, and High-throughput sequencing to determine de novo long-range chromatin interactions genome-wide.
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ChIP-sequencing
ChIP-sequencing, also known as ChIP-seq, is a method used to analyze protein interactions with DNA.
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Chromatin
Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.
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Chromatin immunoprecipitation
Chromatin immunoprecipitation (ChIP) is a type of immunoprecipitation experimental technique used to investigate the interaction between proteins and DNA in the cell.
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Chromosome
A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.
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Chromosome territories
In cell biology, chromosome territories are regions of the nucleus preferentially occupied by particular chromosomes.
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Crosslinking of DNA
In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA, forming a covalent linkage between them.
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DNA ligase
DNA ligase is a specific type of enzyme, a ligase, that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond.
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EcoRI
EcoRI (pronounced "eco R one") is a restriction endonuclease enzyme isolated from species E. coli. The Eco part of the enzyme's name originates from the species from which it was isolated, while the R represents the particular strain, in this case RY13.
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Eigendecomposition of a matrix
In linear algebra, eigendecomposition or sometimes spectral decomposition is the factorization of a matrix into a canonical form, whereby the matrix is represented in terms of its eigenvalues and eigenvectors.
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Emil Heitz
Emil Heitz (born 19 October 1892 in Strasbourg, then part of the German Empire - died 8 July 1965 in Lugano, Switzerland) was a German-Swiss botanist and geneticist.
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Enhancer (genetics)
In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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Epigenetics & Chromatin
Epigenetics & Chromatin is a peer-reviewed open access scientific journal that covers the biology of epigenetics and chromatin.
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Estrogen
Estrogen, or oestrogen, is the primary female sex hormone.
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Euchromatin
Euchromatin is a lightly packed form of chromatin (DNA, RNA, and protein) that is enriched in genes, and is often (but not always) under active transcription.
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Formaldehyde
No description.
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Genetic testing
Genetic testing, also known as DNA testing, allows the determination of bloodlines and the genetic diagnosis of vulnerabilities to inherited diseases.
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Globin
The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen.
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Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts.
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Heinrich Wilhelm Gottfried von Waldeyer-Hartz
Heinrich Wilhelm Gottfried von Waldeyer-Hartz (6 October 1836 – 23 January 1921) was a German anatomist, famous for consolidating the neuron theory of organization of the nervous system and for naming the chromosome.
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HeLa
HeLa (also Hela or hela) is a cell type in an immortal cell line used in scientific research.
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Hep G2
Hep G2 is a human liver cancer cell line.
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Heterochromatin
Heterochromatin is a tightly packed form of DNA or condensed DNA, which comes in multiple varieties.
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HindIII
HindIII (pronounced "Hin D Three") is a type II site-specific deoxyribonuclease restriction enzyme isolated from Haemophilus influenzae that cleaves the DNA palindromic sequence AAGCTT in the presence of the cofactor Mg2+ via hydrolysis.
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Holoprosencephaly
Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres.
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Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the sequence of nucleotide base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.
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Immortalised cell line
An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.
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Inverse polymerase chain reaction
Inverse polymerase chain reaction (Inverse PCR) is a variant of the polymerase chain reaction that is used to amplify DNA with only one known sequence.
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John T. Lis
John T. Lis (born in Willimantic, Connecticut) is the Barbara McClintock Professor of Molecular Biology & Genetics at the Cornell University College of Agriculture and Life Sciences.
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K562 cells
K562 cells were the first human immortalised myelogenous leukemia cell line to be established.
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Ligation (molecular biology)
In molecular biology, ligation is the joining of two nucleic acid fragments through the action of an enzyme.
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LNCaP
LNCaP cells are a cell line of human cells commonly used in the field of oncology.
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Locus (genetics)
A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).
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Mary F. Lyon
Mary Frances Lyon (15 May 1925 – 25 December 2014) was an English geneticist, best known for her discovery of X-chromosome inactivation, an important biological phenomenon.
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Microscopy
Microscopy is the technical field of using microscopes to view objects and areas of objects that cannot be seen with the naked eye (objects that are not within the resolution range of the normal eye).
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NCI-60
The NCI-60 cancer cell line panel is a group of 60 human cancer cell lines used by the National Cancer Institute (NCI) for the screening of compounds to detect potential anticancer activity.
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Nuclear organization
Nuclear organization refers to the spatial distribution of chromatin within a cell nucleus.
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Nucleosome
A nucleosome is a basic unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound in sequence around eight histone protein cores.
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Nucleotide
Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.
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Oligonucleotide
Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.
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PANC-1
PANC-1 is a human pancreatic cancer cell line isolated from a pancreatic carcinoma of ductal cell origin.
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Polymer
A polymer (Greek poly-, "many" + -mer, "part") is a large molecule, or macromolecule, composed of many repeated subunits.
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Polymerase chain reaction
Polymerase chain reaction (PCR) is a technique used in molecular biology to amplify a single copy or a few copies of a segment of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.
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Primer (molecular biology)
A primer is a short strand of RNA or DNA (generally about 18-22 bases) that serves as a starting point for DNA synthesis.
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Prolactin
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.
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Promoter (genetics)
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.
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Restriction enzyme
A restriction enzyme or restriction endonuclease is an enzyme that cleaves DNA into fragments at or near specific recognition sites within the molecule known as restriction sites.
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Rollin Hotchkiss
Rollin Douglas Hotchkiss (1911 – December 12, 2004) was an American biochemist who helped to establish the role of DNA as the genetic material and contributed to the isolation and purification of the first antibiotics.
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Sequence motif
In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.
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Shotgun sequencing
In genetics, shotgun sequencing is a method used for sequencing long DNA strands.
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T-47D
T-47D is a human breast cancer cell line commonly used in biomedical research involving the hormonal expression of cancer cells.
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Theodor Boveri
Theodor Heinrich Boveri (12 October 1862 – 15 October 1915) was a German biologist.
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Topologically associating domain
A topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD.
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Transcriptional regulation
In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.
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Walter Sutton
Walter Stanborough Sutton (April 5, 1877 – November 10, 1916) was an American geneticist and physician whose most significant contribution to present-day biology was his theory that the Mendelian laws of inheritance could be applied to chromosomes at the cellular level of living organisms.
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Walther Flemming
Walther Flemming (21 April 1843 – 4 August 1905) was a German biologist and a founder of cytogenetics.
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X-inactivation
X-inactivation (also called lyonization) is a process by which one of the copies of the X chromosome present in female mammals is inactivated.
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Redirects here:
Chromosome comformation capture, Hi-C (experiment).
References
[1] https://en.wikipedia.org/wiki/Chromosome_conformation_capture
