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Claisen condensation

Index Claisen condensation

The Claisen condensation is a carbon–carbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a β-keto ester or a β-diketone. [1]

46 relations: Acid, Aldol condensation, Alkoxide, Alpha and beta carbon, Aqueous solution, Base (chemistry), Benzophenone, Carbon–carbon bond, Carbonyl group, Carboxylic acid, Condensation reaction, Cyclic compound, Delocalized electron, Deprotonation, Dieckmann condensation, Diketone, Electrophile, Endergonic reaction, Enol, Ester, Ethanol, Ethyl group, Fatty acid synthesis, Intramolecular force, Lactone, Leaving group, Lithium diisopropylamide, Methoxide, Methyl group, Neutralization (chemistry), Non-nucleophilic base, Nucleophile, Nucleophilic addition, Nucleophilic substitution, Organic reaction, Phosphoric acid, Polyketide synthase, Rainer Ludwig Claisen, Reaction mechanism, Reagent, Ring strain, Sodium ethoxide, Stoichiometry, Substrate (chemistry), Succinic acid, Sulfuric acid.


An acid is a molecule or ion capable of donating a hydron (proton or hydrogen ion H+), or, alternatively, capable of forming a covalent bond with an electron pair (a Lewis acid).

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Aldol condensation

An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone (an aldol reaction), followed by dehydration to give a conjugated enone.

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An alkoxide is the conjugate base of an alcohol and therefore consists of an organic group bonded to a negatively charged oxygen atom.

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Alpha and beta carbon

The alpha carbon (Cα) in organic molecules refers to the first carbon atom that attaches to a functional group, such as a carbonyl.

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Aqueous solution

An aqueous solution is a solution in which the solvent is water.

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Base (chemistry)

In chemistry, bases are substances that, in aqueous solution, release hydroxide (OH−) ions, are slippery to the touch, can taste bitter if an alkali, change the color of indicators (e.g., turn red litmus paper blue), react with acids to form salts, promote certain chemical reactions (base catalysis), accept protons from any proton donor, and/or contain completely or partially displaceable OH− ions.

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Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO.

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Carbon–carbon bond

A carbon–carbon bond is a covalent bond between two carbon atoms.

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Carbonyl group

In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C.

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Carboxylic acid

A carboxylic acid is an organic compound that contains a carboxyl group (C(.

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Condensation reaction

A condensation reaction is a class of an organic addition reaction that proceeds in a step-wise fashion to produce the addition product, usually in equilibrium, and a water molecule (hence named condensation).

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Cyclic compound

A cyclic compound (ring compound) is a term for a compound in the field of chemistry in which one or more series of atoms in the compound is connected to form a ring.

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Delocalized electron

In chemistry, delocalized electrons are electrons in a molecule, ion or solid metal that are not associated with a single atom or a covalent bond.

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Deprotonation is the removal (transfer) of a proton (a hydrogen cation, H+) from a Brønsted–Lowry acid in an acid-base reaction.

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Dieckmann condensation

The Dieckmann condensation is the intramolecular chemical reaction of diesters with base to give β-keto esters.

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A diketone or dione is a molecule containing two ketone groups.

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In organic chemistry, an electrophile is a reagent attracted to electrons.

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Endergonic reaction

In chemical thermodynamics, an endergonic reaction (also called a heat absorb nonspontaneous reaction or an unfavorable reaction) is a chemical reaction in which the standard change in free energy is positive, and energy is absorbed.

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Enols, or more formally, alkenols, are a type of reactive structure or intermediate in organic chemistry that is represented as an alkene (olefin) with a hydroxyl group attached to one end of the alkene double bond.

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In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.

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Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.

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Ethyl group

In chemistry, an ethyl group is an alkyl substituent derived from ethane (C2H6).

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Fatty acid synthesis

Fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases.

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Intramolecular force

An intramolecular force is any force that binds together the atoms making up a molecule or compound, not to be confused with intermolecular forces, which are the forces present between molecules.

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Lactones are cyclic esters of hydroxycarboxylic acids, containing a 1-oxacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.

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Leaving group

In chemistry, a leaving group is a molecular fragment that departs with a pair of electrons in heterolytic bond cleavage.

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Lithium diisopropylamide

Lithium diisopropylamide (commonly abbreviated LDA) is a chemical compound with the molecular formula 2NLi.

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Methoxides are organic salts and the simplest alkoxides.

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Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

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Neutralization (chemistry)

In chemistry, neutralization or neutralisation (see spelling differences), is a chemical reaction in which an acid and a base react quantitatively with each other.

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Non-nucleophilic base

As the name suggests, a non-nucleophilic base is a sterically hindered organic base that is a poor nucleophile.

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Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.

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Nucleophilic addition

In organic chemistry, a nucleophilic addition reaction is an addition reaction where a chemical compound with an electron-deficient or electrophilic double or triple bond, a π bond, reacts with electron-rich reactant, termed a nucleophile, with disappearance of the double bond and creation of two new single, or σ, bonds.

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Nucleophilic substitution

In organic and inorganic chemistry, nucleophilic substitution is a fundamental class of reactions in which an electron rich nucleophile selectively bonds with or attacks the positive or partially positive charge of an atom or a group of atoms to replace a leaving group; the positive or partially positive atom is referred to as an electrophile.

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Organic reaction

Organic reactions are chemical reactions involving organic compounds.

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Phosphoric acid

Phosphoric acid (also known as orthophosphoric acid or phosphoric(V) acid) is a mineral (inorganic) and weak acid having the chemical formula H3PO4.

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Polyketide synthase

Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages.

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Rainer Ludwig Claisen

Rainer Ludwig Claisen (14 January 1851 – 5 January 1930) was a German chemist best known for his work with condensations of carbonyls and sigmatropic rearrangements.

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Reaction mechanism

In chemistry, a reaction mechanism is the step by step sequence of elementary reactions by which overall chemical change occurs.

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A reagent is a substance or compound added to a system to cause a chemical reaction, or added to test if a reaction occurs.

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Ring strain

In organic chemistry, ring strain is a type of instability that exists when bonds in a molecule form angles that are abnormal.

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Sodium ethoxide

Sodium ethoxide (also is the organic compound with the formula C2H5ONa) is a white to yellowish powder that dissolves in polar solvents such as ethanol.

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Stoichiometry is the calculation of reactants and products in chemical reactions.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Succinic acid

Succinic acid is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2.

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Sulfuric acid

Sulfuric acid (alternative spelling sulphuric acid) is a mineral acid with molecular formula H2SO4.

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Redirects here:

Acetoacetic ester condensation, Claisen Condensation, Claisen ester condensation, Claisen ester condensations, Claisen reaction, Stobbe condensation, Stobbe reaction.


[1] https://en.wikipedia.org/wiki/Claisen_condensation

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