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Cyclin-dependent kinase 1

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Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. [1]

34 relations: Adenosine triphosphate, Bcl-2, Cdc25, CDKN3, Cell cycle, Cyclin, Cyclin A, Cyclin B, Cyclin B1, Cyclin D, Cyclin E, Cyclin E1, Cyclin-dependent kinase, DAB2, Fanconi anemia, complementation group C, GADD45A, Gene, Hydroxy group, Hyperphosphorylation, Kinase, LATS1, LYN, Maturation promoting factor, P53, Phosphorylation, Pom1, Protein, Protein–protein interaction, Regulon, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Sic1, Ubiquitin C, Wee1.

Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

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Bcl-2

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.

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Cdc25

Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant.

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CDKN3

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Cyclin

Cyclin is a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.

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Cyclin A

Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle.

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Cyclin B

Cyclin B is a member of the cyclin family.

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Cyclin B1

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.

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Cyclin D

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression.

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Cyclin E

Cyclin E is a member of the cyclin family.

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Cyclin E1

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.

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Cyclin-dependent kinase

Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle.

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DAB2

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.

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Fanconi anemia, complementation group C

Fanconi anemia group C protein is a protein that in humans is encoded by the FANCC gene.

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GADD45A

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Hydroxy group

A hydroxy or hydroxyl group is the entity with the formula OH.

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Hyperphosphorylation

Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated.

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Kinase

In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

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LATS1

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene.

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LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.

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Maturation promoting factor

Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs.

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P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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Phosphorylation

In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.

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Pom1

Pom1 is a polarity protein kinase in fission yeast, Schizosaccharomyces pombe (S. pombe), that localizes to cell ends and regulates cell division.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Regulon

In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory gene that expresses a protein acting as a repressor or activator.

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Saccharomyces cerevisiae

Saccharomyces cerevisiae is a species of yeast.

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Schizosaccharomyces pombe

Schizosaccharomyces pombe, also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology.

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Sic1

Sic1, a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae.

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Ubiquitin C

Polyubiquitin-C is a protein encoded by the UBC gene in humans.

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Wee1

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe).

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Redirects here:

CDC2, CDC28 protein kinase, CDK1, CDK1 (gene), Cdc2, Cdc28, Cdk 1, Cdk1, Protein 34, Protein P34cdc2.

References

[1] https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_1

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