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Dehydroepiandrosterone

Index Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. [1]

Table of Contents

  1. 164 relations: Acne, Adolf Butenandt, Adrenal cortex, Adrenal gland, Adrenarche, Adrenocorticotropic hormone, Agonist, Allosteric modulator, Androgen, Androgen receptor, Androstane, Androstenediol, Androstenedione, Anti-inflammatory, Anti-obesity medication, Antiandrogen, Anticarcinogen, Antiglucocorticoid, Bile salt sulfotransferase, Biological activity, Biological half-life, Biosynthesis, Blood–brain barrier, Body hair, Body odor, Brain-derived neurotrophic factor, Calorie restriction, Cell surface receptor, Cellular differentiation, Central nervous system, Cholesterol, Cholesterol side-chain cleavage enzyme, Circulatory system, Competitive inhibition, Complete androgen insensitivity syndrome, Congenital adrenal hyperplasia, Constitutive androstane receptor, Cortisol, CYP17A1, CYP2C9, Dehydroandrosterone, Dehydroepiandrosterone sulfate, Dehydrogenation, Diabetes medication, Dietary supplement, Dihydrotestosterone, EC50, Endogeny (biology), Enzyme, Epiandrosterone, ... Expand index (114 more) »

  2. Hormones of the hypothalamus-pituitary-gonad axis
  3. Muscle protectors
  4. Muscle stabilizers
  5. NMDA receptor agonists
  6. Pheromones
  7. Pregnane X receptor agonists
  8. Sex hormones

Acne

Acne, also known as acne vulgaris, is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles.

See Dehydroepiandrosterone and Acne

Adolf Butenandt

Adolf Friedrich Johann Butenandt (24 March 1903 – 18 January 1995) was a German biochemist.

See Dehydroepiandrosterone and Adolf Butenandt

Adrenal cortex

The adrenal cortex is the outer region and also the largest part of the adrenal gland.

See Dehydroepiandrosterone and Adrenal cortex

Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

See Dehydroepiandrosterone and Adrenal gland

Adrenarche

Adrenarche is an early stage in sexual maturation that happens in some higher primates (including humans), typically peaks at around 20 years of age, and is involved in the development of pubic hair, body odor, skin oiliness, axillary hair, sexual attraction/sexual desire/increased libido and mild acne.

See Dehydroepiandrosterone and Adrenarche

Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

See Dehydroepiandrosterone and Adrenocorticotropic hormone

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

See Dehydroepiandrosterone and Agonist

Allosteric modulator

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

See Dehydroepiandrosterone and Allosteric modulator

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. Dehydroepiandrosterone and androgen are Anabolic–androgenic steroids, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Androgen

Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus.

See Dehydroepiandrosterone and Androgen receptor

Androstane

Androstane is a C19 steroidal hydrocarbon with a gonane core. Dehydroepiandrosterone and Androstane are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone and Androstane

Androstenediol

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA). Dehydroepiandrosterone and Androstenediol are Anabolic–androgenic steroids, androstanes, estrogens and pregnane X receptor agonists.

See Dehydroepiandrosterone and Androstenediol

Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA). Dehydroepiandrosterone and Androstenedione are Anabolic–androgenic steroids, androstanes, estrogens and pregnane X receptor agonists.

See Dehydroepiandrosterone and Androstenedione

Anti-inflammatory

Anti-inflammatory or antiphlogistic is the property of a substance or treatment that reduces inflammation or swelling.

See Dehydroepiandrosterone and Anti-inflammatory

Anti-obesity medication

Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat.

See Dehydroepiandrosterone and Anti-obesity medication

Antiandrogen

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body. Dehydroepiandrosterone and Antiandrogen are sex hormones.

See Dehydroepiandrosterone and Antiandrogen

Anticarcinogen

An anticarcinogen (also known as a carcinopreventive agent) is a substance that counteracts the effects of a carcinogen or inhibits the development of cancer.

See Dehydroepiandrosterone and Anticarcinogen

Antiglucocorticoid

An antiglucocorticoid is a drug which reduces glucocorticoid activity in the body.

See Dehydroepiandrosterone and Antiglucocorticoid

Bile salt sulfotransferase

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

See Dehydroepiandrosterone and Bile salt sulfotransferase

Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

See Dehydroepiandrosterone and Biological activity

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Dehydroepiandrosterone and Biological half-life

Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

See Dehydroepiandrosterone and Biosynthesis

Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

See Dehydroepiandrosterone and Blood–brain barrier

Body hair

Body hair or androgenic hair is terminal hair that develops on the human body during and after puberty.

See Dehydroepiandrosterone and Body hair

Body odor

Body odor or body odour (BO) is present in all animals and its intensity can be influenced by many factors (behavioral patterns, survival strategies).

See Dehydroepiandrosterone and Body odor

Brain-derived neurotrophic factor

Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein found in the and the periphery.

See Dehydroepiandrosterone and Brain-derived neurotrophic factor

Calorie restriction

Calorie restriction (also known as caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition.

See Dehydroepiandrosterone and Calorie restriction

Cell surface receptor

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells.

See Dehydroepiandrosterone and Cell surface receptor

Cellular differentiation

Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one.

See Dehydroepiandrosterone and Cellular differentiation

Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

See Dehydroepiandrosterone and Central nervous system

Cholesterol

Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Dehydroepiandrosterone and Cholesterol are neurosteroids.

See Dehydroepiandrosterone and Cholesterol

Cholesterol side-chain cleavage enzyme

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage.

See Dehydroepiandrosterone and Cholesterol side-chain cleavage enzyme

Circulatory system

The circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate.

See Dehydroepiandrosterone and Circulatory system

Competitive inhibition

Competitive inhibition is interruption of a chemical pathway owing to one chemical substance inhibiting the effect of another by competing with it for binding or bonding.

See Dehydroepiandrosterone and Competitive inhibition

Complete androgen insensitivity syndrome

Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens.

See Dehydroepiandrosterone and Complete androgen insensitivity syndrome

Congenital adrenal hyperplasia

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis.

See Dehydroepiandrosterone and Congenital adrenal hyperplasia

Constitutive androstane receptor

The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene.

See Dehydroepiandrosterone and Constitutive androstane receptor

Cortisol

Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.

See Dehydroepiandrosterone and Cortisol

CYP17A1

Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.

See Dehydroepiandrosterone and CYP17A1

CYP2C9

Cytochrome P450 family 2 subfamily C member 9 (abbreviated CYP2C9) is an enzyme protein.

See Dehydroepiandrosterone and CYP2C9

Dehydroandrosterone

Dehydroandrosterone (DHA), or 5-dehydroandrosterone (5-DHA), also known as isoandrostenolone, as well as androst-5-en-3α-ol-17-one, is an endogenous androgen steroid hormone. Dehydroepiandrosterone and Dehydroandrosterone are Anabolic–androgenic steroids, androstanes, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Dehydroandrosterone

Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. Dehydroepiandrosterone and Dehydroepiandrosterone sulfate are Anabolic–androgenic steroids, androstanes, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone and Dehydroepiandrosterone sulfate

Dehydrogenation

In chemistry, dehydrogenation is a chemical reaction that involves the removal of hydrogen, usually from an organic molecule.

See Dehydroepiandrosterone and Dehydrogenation

Diabetes medication

Drugs used in diabetes treat diabetes mellitus by decreasing glucose levels in the blood.

See Dehydroepiandrosterone and Diabetes medication

Dietary supplement

A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill, capsule, tablet, powder, or liquid.

See Dehydroepiandrosterone and Dietary supplement

Dihydrotestosterone

Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition. Dehydroepiandrosterone and Dihydrotestosterone are Anabolic–androgenic steroids, androstanes, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Dihydrotestosterone

EC50

Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time.

See Dehydroepiandrosterone and EC50

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See Dehydroepiandrosterone and Endogeny (biology)

Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

See Dehydroepiandrosterone and Enzyme

Epiandrosterone

Epiandrosterone, or isoandrosterone, also known as 3β-androsterone, 3β-hydroxy-5α-androstan-17-one, or 5α-androstan-3β-ol-17-one, is a steroid hormone with weak androgenic activity. Dehydroepiandrosterone and Epiandrosterone are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone and Epiandrosterone

Epigenetic clock

An epigenetic clock is a biochemical test that can be used to measure age.

See Dehydroepiandrosterone and Epigenetic clock

Epimer

In stereochemistry, an epimer is one of a pair of diastereomers.

See Dehydroepiandrosterone and Epimer

Estetrol

Estetrol (E4), or oestetrol, is one of the four natural estrogenic steroid hormones found in humans, along with estrone (E1), estradiol (E2), and estriol (E3). Dehydroepiandrosterone and Estetrol are estrogens, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Estetrol

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Dehydroepiandrosterone and Estradiol are estrogens, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Estradiol

Estriol

Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone. Dehydroepiandrosterone and Estriol are estrogens, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Estriol

Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Dehydroepiandrosterone and Estrogen are estrogens, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Estrogen

Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

See Dehydroepiandrosterone and Estrogen receptor

Estrogen receptor alpha

Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein) that is activated by the sex hormone estrogen.

See Dehydroepiandrosterone and Estrogen receptor alpha

Estrogen receptor beta

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen.

See Dehydroepiandrosterone and Estrogen receptor beta

Evolution

Evolution is the change in the heritable characteristics of biological populations over successive generations.

See Dehydroepiandrosterone and Evolution

Exogeny

In a variety of contexts, exogeny or exogeneity is the fact of an action or object originating externally.

See Dehydroepiandrosterone and Exogeny

Fetus

A fetus or foetus (fetuses, foetuses, rarely feti or foeti) is the unborn offspring that develops from a mammal embryo.

See Dehydroepiandrosterone and Fetus

First pass effect

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.

See Dehydroepiandrosterone and First pass effect

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Dehydroepiandrosterone and GABAA receptor

Gastrointestinal tract

The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.

See Dehydroepiandrosterone and Gastrointestinal tract

Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

See Dehydroepiandrosterone and Glucocorticoid

Glucocorticoid receptor

The glucocorticoid receptor (GR or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.

See Dehydroepiandrosterone and Glucocorticoid receptor

Gonad

A gonad, sex gland, or reproductive gland is a mixed gland that produces the gametes and sex hormones of an organism.

See Dehydroepiandrosterone and Gonad

Gonadotropin-releasing hormone

Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. Dehydroepiandrosterone and Gonadotropin-releasing hormone are hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Gonadotropin-releasing hormone

Growth inhibition

Growth inhibition (GI) is a medical term pertaining to cancer therapy and the specific reduction in growth of tumors and oncogene cells by a chemical compound, mechanical therapy (e.g. electroporation), radiation, gene therapy, protein therapy, ultrasound waves, light, or any other treatment.

See Dehydroepiandrosterone and Growth inhibition

Hair follicle

The hair follicle is an organ found in mammalian skin.

See Dehydroepiandrosterone and Hair follicle

Human serum albumin

Human serum albumin is the serum albumin found in human blood.

See Dehydroepiandrosterone and Human serum albumin

IC50

Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.

See Dehydroepiandrosterone and IC50

IGFBP1

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

See Dehydroepiandrosterone and IGFBP1

Immunotherapy

Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system.

See Dehydroepiandrosterone and Immunotherapy

In vitro

In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

See Dehydroepiandrosterone and In vitro

In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

See Dehydroepiandrosterone and In vivo

Injection (medicine)

An injection (often and usually referred to as a "shot" in US English, a "jab" in UK English, or a "jag" in Scottish English and Scots) is the act of administering a liquid, especially a drug, into a person's body using a needle (usually a hypodermic needle) and a syringe.

See Dehydroepiandrosterone and Injection (medicine)

Intramuscular injection

Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle.

See Dehydroepiandrosterone and Intramuscular injection

Intravaginal administration

Intravaginal administration is a route of administration where the substance is applied inside the vagina.

See Dehydroepiandrosterone and Intravaginal administration

Intrinsic activity

Intrinsic activity (IA) and efficacy refer to the relative ability of a drug-receptor complex to produce a maximum functional response.

See Dehydroepiandrosterone and Intrinsic activity

Ketosteroid

Androstenedione Androsterone Estrone A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C.

See Dehydroepiandrosterone and Ketosteroid

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

See Dehydroepiandrosterone and Ligand (biochemistry)

Lipid-lowering agent

Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic agents are a diverse group of pharmaceuticals that are used to lower the level of lipids and lipoproteins, such as cholesterol, in the blood (hyperlipidemia).

See Dehydroepiandrosterone and Lipid-lowering agent

Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

See Dehydroepiandrosterone and Liver

Low-affinity nerve growth factor receptor

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor.

See Dehydroepiandrosterone and Low-affinity nerve growth factor receptor

Membrane transport protein

A membrane transport protein is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane.

See Dehydroepiandrosterone and Membrane transport protein

Metabolic intermediate

Metabolic intermediates are molecules that are the precursors or metabolites of biologically significant molecules.

See Dehydroepiandrosterone and Metabolic intermediate

Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

See Dehydroepiandrosterone and Metabolism

Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

See Dehydroepiandrosterone and Metabolite

Microtubule-associated protein 2

Microtubule-associated protein 2 is a protein in humans that is encoded by the MAP2 gene.

See Dehydroepiandrosterone and Microtubule-associated protein 2

Mineralocorticoid receptor

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.

See Dehydroepiandrosterone and Mineralocorticoid receptor

Molar concentration

Molar concentration (also called molarity, amount concentration or substance concentration) is a measure of the concentration of a chemical species, in particular, of a solute in a solution, in terms of amount of substance per unit volume of solution.

See Dehydroepiandrosterone and Molar concentration

Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

See Dehydroepiandrosterone and Molecular binding

Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

See Dehydroepiandrosterone and Natural product

Nerve growth factor

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.

See Dehydroepiandrosterone and Nerve growth factor

Nervous system

In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body.

See Dehydroepiandrosterone and Nervous system

Neurodegenerative disease

A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration.

See Dehydroepiandrosterone and Neurodegenerative disease

Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Dehydroepiandrosterone and Neurosteroid are neurosteroids.

See Dehydroepiandrosterone and Neurosteroid

Neurotransmitter receptor

A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter.

See Dehydroepiandrosterone and Neurotransmitter receptor

Neurotrophic factor receptor

Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors).

See Dehydroepiandrosterone and Neurotrophic factor receptor

Neurotrophic factors

Neurotrophic factors (NTFs) are a family of biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons.

See Dehydroepiandrosterone and Neurotrophic factors

Neurotrophin

Neurotrophins are a family of proteins that induce the survival, development, and function of neurons.

See Dehydroepiandrosterone and Neurotrophin

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.

See Dehydroepiandrosterone and NMDA receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules.

See Dehydroepiandrosterone and Nuclear receptor

Oral administration

| name.

See Dehydroepiandrosterone and Oral administration

Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescription.

See Dehydroepiandrosterone and Over-the-counter drug

Ovulation

Ovulation is the release of eggs from the ovaries.

See Dehydroepiandrosterone and Ovulation

Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

See Dehydroepiandrosterone and Partial agonist

Peptide

Peptides are short chains of amino acids linked by peptide bonds.

See Dehydroepiandrosterone and Peptide

Peroxisome proliferator-activated receptor

In the field of molecular biology, the peroxisome proliferator–activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes.

See Dehydroepiandrosterone and Peroxisome proliferator-activated receptor

Pharmacodynamics

Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).

See Dehydroepiandrosterone and Pharmacodynamics

Polycystic ovary syndrome

Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age.

See Dehydroepiandrosterone and Polycystic ovary syndrome

Potency (pharmacology)

In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.

See Dehydroepiandrosterone and Potency (pharmacology)

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) and sold under the brand name Intrarosa among others, is a medication as well as over-the-counter dietary supplement which is used to correct DHEA deficiency due to adrenal insufficiency or old age, as a component of menopausal hormone therapy, to treat painful sexual intercourse due to vaginal atrophy, and to prepare the cervix for childbirth, among other uses. Dehydroepiandrosterone and Prasterone are Anabolic–androgenic steroids, androstanes, estrogens, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone and Prasterone

Prasterone enanthate

Prasterone enanthate, also known as dehydroepiandrosterone enanthate (DHEA-E) and sold in combination with estradiol valerate under the brand name Gynodian Depot among others, is a weak androgen, estrogen, and neurosteroid medication which is used as a component of menopausal hormone therapy to treat menopausal symptoms in women. Dehydroepiandrosterone and Prasterone enanthate are Anabolic–androgenic steroids, androstanes, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone and Prasterone enanthate

Prasterone sulfate

Prasterone sulfate (brand names Astenile, Mylis, Teloin, others), also known as dehydroepiandrosterone sulfate (DHEA-S), is a naturally occurring androstane steroid which is marketed and used in Japan and other countries as a labor inducer in the treatment of insufficient cervical ripening and dilation during childbirth. Dehydroepiandrosterone and Prasterone sulfate are Anabolic–androgenic steroids, androstanes, estrogens, GABAA receptor negative allosteric modulators, NMDA receptor agonists, neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone and Prasterone sulfate

Precursor (chemistry)

In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.

See Dehydroepiandrosterone and Precursor (chemistry)

Pregnane X receptor

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene.

See Dehydroepiandrosterone and Pregnane X receptor

Pregnenolone

Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. Dehydroepiandrosterone and Pregnenolone are neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone and Pregnenolone

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Dehydroepiandrosterone and Progesterone are hormones of the hypothalamus-pituitary-gonad axis, neurosteroids, pregnane X receptor agonists and sex hormones.

See Dehydroepiandrosterone and Progesterone

Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells.

See Dehydroepiandrosterone and Progesterone receptor

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

See Dehydroepiandrosterone and Protein

Pubarche

Pubarche refers to the first appearance of pubic hair at puberty and it also marks the beginning of puberty.

See Dehydroepiandrosterone and Pubarche

Puberty

Puberty is the process of physical changes through which a child's body matures into an adult body capable of sexual reproduction.

See Dehydroepiandrosterone and Puberty

Pubic hair

Pubic hair (or pubes) is terminal body hair that is found in the genital area of adolescent and adult humans.

See Dehydroepiandrosterone and Pubic hair

Quest Diagnostics

Quest Diagnostics Incorporated is an American clinical laboratory.

See Dehydroepiandrosterone and Quest Diagnostics

Radical (chemistry)

In chemistry, a radical, also known as a free radical, is an atom, molecule, or ion that has at least one unpaired valence electron.

See Dehydroepiandrosterone and Radical (chemistry)

Sex hormone

Sex hormones, also known as sex steroids, gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate steroid hormone receptors. Dehydroepiandrosterone and sex hormone are hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Sex hormone

Sex hormone-binding globulin

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens.

See Dehydroepiandrosterone and Sex hormone-binding globulin

Sigma-1 receptor

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.

See Dehydroepiandrosterone and Sigma-1 receptor

Small molecule

In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.

See Dehydroepiandrosterone and Small molecule

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

See Dehydroepiandrosterone and Steroid

Steroid hormone

A steroid hormone is a steroid that acts as a hormone.

See Dehydroepiandrosterone and Steroid hormone

Steroid sulfatase

Steroid sulfatase (STS), or steryl-sulfatase (EC 3.1.6.2), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids.

See Dehydroepiandrosterone and Steroid sulfatase

Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

See Dehydroepiandrosterone and Structural analog

Sulfation

Sulfation is the chemical reaction that entails the addition of SO3 group.

See Dehydroepiandrosterone and Sulfation

Sulfotransferase

In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine.

See Dehydroepiandrosterone and Sulfotransferase

SULT1E1

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.

See Dehydroepiandrosterone and SULT1E1

Suppository

A suppository is a dosage form used to deliver medications by insertion into a body orifice (any opening in the body), where it dissolves or melts to exert local or systemic effects.

See Dehydroepiandrosterone and Suppository

Testosterone

Testosterone is the primary male sex hormone and androgen in males. Dehydroepiandrosterone and Testosterone are Anabolic–androgenic steroids, androstanes, estrogens, hormones of the hypothalamus-pituitary-gonad axis and sex hormones.

See Dehydroepiandrosterone and Testosterone

Tissue (biology)

In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function.

See Dehydroepiandrosterone and Tissue (biology)

Tropomyosin receptor kinase A

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

See Dehydroepiandrosterone and Tropomyosin receptor kinase A

Tropomyosin receptor kinase B

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene.

See Dehydroepiandrosterone and Tropomyosin receptor kinase B

Tropomyosin receptor kinase C

Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene.

See Dehydroepiandrosterone and Tropomyosin receptor kinase C

TRPV1

The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene.

See Dehydroepiandrosterone and TRPV1

Tubulin

Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.

See Dehydroepiandrosterone and Tubulin

Uncompetitive inhibition

Uncompetitive inhibition (which Laidler and Bunting preferred to call anti-competitive inhibition, but this term has not been widely adopted) is a type of inhibition in which the apparent values of the Michaelis–Menten parameters V and K_\mathrm are decreased in the same proportion.

See Dehydroepiandrosterone and Uncompetitive inhibition

Underarm hair

Underarm hair, also known as axillary hair or armpit hair, is the hair in the underarm area (axilla).

See Dehydroepiandrosterone and Underarm hair

Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

See Dehydroepiandrosterone and Urine

Vagina

In mammals and other animals, the vagina (vaginas or vaginae) is the elastic, muscular reproductive organ of the female genital tract.

See Dehydroepiandrosterone and Vagina

Zona reticularis

The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla.

See Dehydroepiandrosterone and Zona reticularis

1-Androsterone

1-Androsterone (also known as 1-andro, 1-dehydroepiandrosterone, 1-DHEA, δ1-epiandrosterone, or 5α-androst-1-en-3β-ol-17-one) is a synthetic, orally active anabolic-androgenic steroid (AAS). Dehydroepiandrosterone and 1-Androsterone are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone and 1-Androsterone

11β-Hydroxysteroid dehydrogenase type 1

11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.

See Dehydroepiandrosterone and 11β-Hydroxysteroid dehydrogenase type 1

15α-Hydroxy-DHEA

15α-Hydroxydehydroepiandrosterone, abbreviated as 15α-hydroxy-DHEA or 15α-OH-DHEA, is an endogenous metabolite of dehydroepiandrosterone (DHEA). Dehydroepiandrosterone and 15α-Hydroxy-DHEA are androstanes.

See Dehydroepiandrosterone and 15α-Hydroxy-DHEA

16α-Hydroxy-DHEA

16α-Hydroxydehydroepiandrosterone (16α-hydroxy-DHEA or 16α-OH-DHEA) is an endogenous metabolite of dehydroepiandrosterone (DHEA). Dehydroepiandrosterone and 16α-Hydroxy-DHEA are androstanes and estrogens.

See Dehydroepiandrosterone and 16α-Hydroxy-DHEA

17α-Hydroxypregnenolone

17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. Dehydroepiandrosterone and 17α-Hydroxypregnenolone are pregnane X receptor agonists.

See Dehydroepiandrosterone and 17α-Hydroxypregnenolone

3β-Methoxypregnenolone

3β-Methoxypregnenolone (developmental code name MAP-4343), or pregnenolone 3β-methyl ether, also known as 3β-methoxypregn-5-en-20-one, is a synthetic neuroactive steroid and derivative of pregnenolone. Dehydroepiandrosterone and 3β-Methoxypregnenolone are neurosteroids.

See Dehydroepiandrosterone and 3β-Methoxypregnenolone

4-Dehydroepiandrosterone

4-Dehydroepiandrosterone (4-DHEA) is a steroid that is an isomer of 5-dehydroepiandrosterone. Dehydroepiandrosterone and 4-Dehydroepiandrosterone are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone and 4-Dehydroepiandrosterone

7-Keto-DHEA

7-Ketodehydroepiandrosterone (7-keto-DHEA, 7-oxo-DHEA), also known as 7-oxoprasterone, is a steroid prohormone produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). Dehydroepiandrosterone and 7-Keto-DHEA are androstanes and estrogens.

See Dehydroepiandrosterone and 7-Keto-DHEA

7α-Hydroxy-DHEA

7α-Hydroxydehydroepiandrosterone (7α-hydroxy-DHEA; 7α-OH-DHEA), also known as 3β,7α-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a major metabolite of dehydroepiandrosterone (DHEA) that is formed by CYP7B1 (steroid 7α-hydroxylase) in tissues such as the prostate gland and by CYP3A4 in the liver. Dehydroepiandrosterone and 7α-Hydroxy-DHEA are androstanes and estrogens.

See Dehydroepiandrosterone and 7α-Hydroxy-DHEA

7α-Hydroxyepiandrosterone

7α-Hydroxyepiandrosterone (7α-OH-EPIA), also known as 3β,7α-dihydroxy-5α-androstan-17-one, is an endogenous, naturally occurring metabolite of epiandrosterone and dehydroepiandrosterone (DHEA) that is formed by the enzyme CYP7B1 in tissues such as the liver and brain. Dehydroepiandrosterone and 7α-Hydroxyepiandrosterone are androstanes.

See Dehydroepiandrosterone and 7α-Hydroxyepiandrosterone

7β-Hydroxy-DHEA

7β-Hydroxydehydroepiandrosterone (7β-hydroxy-DHEA; 7β-OH-DHEA), also known as 3β,7β-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a metabolite of dehydroepiandrosterone (DHEA). Dehydroepiandrosterone and 7β-Hydroxy-DHEA are androstanes.

See Dehydroepiandrosterone and 7β-Hydroxy-DHEA

7β-Hydroxyepiandrosterone

7β-Hydroxyepiandrosterone (7β-OH-EPIA), also known as 5α-androstan-3β,7β-diol-17-one, is an endogenous androgen, estrogen, and neurosteroid that is produced from dehydroepiandrosterone and epiandrosterone. Dehydroepiandrosterone and 7β-Hydroxyepiandrosterone are Anabolic–androgenic steroids, androstanes and neurosteroids.

See Dehydroepiandrosterone and 7β-Hydroxyepiandrosterone

See also

Hormones of the hypothalamus-pituitary-gonad axis

Muscle protectors

Muscle stabilizers

NMDA receptor agonists

Pheromones

Pregnane X receptor agonists

Sex hormones

References

[1] https://en.wikipedia.org/wiki/Dehydroepiandrosterone

Also known as 5,6-DHEA, 5,6-Dehydroepiandrosterone, 5,6-Didehydroepiandrosterone, 5-DHEA, 5-Dehydroepiandrosterone, DHEA, Dehydroisoandrosterone, Dehydropiandrosterone.

, Epigenetic clock, Epimer, Estetrol, Estradiol, Estriol, Estrogen, Estrogen receptor, Estrogen receptor alpha, Estrogen receptor beta, Evolution, Exogeny, Fetus, First pass effect, GABAA receptor, Gastrointestinal tract, Glucocorticoid, Glucocorticoid receptor, Gonad, Gonadotropin-releasing hormone, Growth inhibition, Hair follicle, Human serum albumin, IC50, IGFBP1, Immunotherapy, In vitro, In vivo, Injection (medicine), Intramuscular injection, Intravaginal administration, Intrinsic activity, Ketosteroid, Ligand (biochemistry), Lipid-lowering agent, Liver, Low-affinity nerve growth factor receptor, Membrane transport protein, Metabolic intermediate, Metabolism, Metabolite, Microtubule-associated protein 2, Mineralocorticoid receptor, Molar concentration, Molecular binding, Natural product, Nerve growth factor, Nervous system, Neurodegenerative disease, Neurosteroid, Neurotransmitter receptor, Neurotrophic factor receptor, Neurotrophic factors, Neurotrophin, NMDA receptor, Nuclear receptor, Oral administration, Over-the-counter drug, Ovulation, Partial agonist, Peptide, Peroxisome proliferator-activated receptor, Pharmacodynamics, Polycystic ovary syndrome, Potency (pharmacology), Prasterone, Prasterone enanthate, Prasterone sulfate, Precursor (chemistry), Pregnane X receptor, Pregnenolone, Progesterone, Progesterone receptor, Protein, Pubarche, Puberty, Pubic hair, Quest Diagnostics, Radical (chemistry), Sex hormone, Sex hormone-binding globulin, Sigma-1 receptor, Small molecule, Steroid, Steroid hormone, Steroid sulfatase, Structural analog, Sulfation, Sulfotransferase, SULT1E1, Suppository, Testosterone, Tissue (biology), Tropomyosin receptor kinase A, Tropomyosin receptor kinase B, Tropomyosin receptor kinase C, TRPV1, Tubulin, Uncompetitive inhibition, Underarm hair, Urine, Vagina, Zona reticularis, 1-Androsterone, 11β-Hydroxysteroid dehydrogenase type 1, 15α-Hydroxy-DHEA, 16α-Hydroxy-DHEA, 17α-Hydroxypregnenolone, 3β-Methoxypregnenolone, 4-Dehydroepiandrosterone, 7-Keto-DHEA, 7α-Hydroxy-DHEA, 7α-Hydroxyepiandrosterone, 7β-Hydroxy-DHEA, 7β-Hydroxyepiandrosterone.