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Dehydroepiandrosterone sulfate

Index Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate, abbreviated as DHEA sulfate or DHEA-S, also known as androstenolone sulfate, is an endogenous androstane steroid that is produced by the adrenal cortex. [1]

Table of Contents

  1. 90 relations: Adrenal cortex, Adrenal gland, Adrenal gland disorder, Adrenal insufficiency, Adrenarche, Adrenocorticotropic hormone, Agonist, Allosteric modulator, Androgen, Androstane, Bile salt sulfotransferase, Bioconjugation, Biological activity, Biological half-life, Blood–brain barrier, Brain-derived neurotrophic factor, Cause (medicine), Central nervous system, Cervical dilation, Cervical effacement, Childbirth, Cholesterol, Cholesterol side-chain cleavage enzyme, Congenital adrenal hyperplasia due to 21-hydroxylase deficiency, Cortisol, Cushing's syndrome, CYP17A1, Dehydroepiandrosterone, Depot injection, Dihydrotestosterone, EMedicine, Endocrine Society, Endogeny (biology), Enzyme, Ester, Estradiol, Estrogen, Estrone, Excretion, GABAA receptor, Glucocorticoid, Glycine receptor, Gonad, Hirsutism, Hormone, Human serum albumin, Hypopituitarism, Idiopathic disease, Japan, Kidney, ... Expand index (40 more) »

  2. NMDA receptor agonists
  3. Pregnane X receptor agonists

Adrenal cortex

The adrenal cortex is the outer region and also the largest part of the adrenal gland.

See Dehydroepiandrosterone sulfate and Adrenal cortex

Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

See Dehydroepiandrosterone sulfate and Adrenal gland

Adrenal gland disorder

Adrenal gland disorders (or diseases) are conditions that interfere with the normal functioning of the adrenal glands.

See Dehydroepiandrosterone sulfate and Adrenal gland disorder

Adrenal insufficiency

Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones.

See Dehydroepiandrosterone sulfate and Adrenal insufficiency

Adrenarche

Adrenarche is an early stage in sexual maturation that happens in some higher primates (including humans), typically peaks at around 20 years of age, and is involved in the development of pubic hair, body odor, skin oiliness, axillary hair, sexual attraction/sexual desire/increased libido and mild acne.

See Dehydroepiandrosterone sulfate and Adrenarche

Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

See Dehydroepiandrosterone sulfate and Adrenocorticotropic hormone

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

See Dehydroepiandrosterone sulfate and Agonist

Allosteric modulator

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

See Dehydroepiandrosterone sulfate and Allosteric modulator

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. Dehydroepiandrosterone sulfate and androgen are Anabolic–androgenic steroids.

See Dehydroepiandrosterone sulfate and Androgen

Androstane

Androstane is a C19 steroidal hydrocarbon with a gonane core. Dehydroepiandrosterone sulfate and Androstane are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone sulfate and Androstane

Bile salt sulfotransferase

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

See Dehydroepiandrosterone sulfate and Bile salt sulfotransferase

Bioconjugation

Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule.

See Dehydroepiandrosterone sulfate and Bioconjugation

Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

See Dehydroepiandrosterone sulfate and Biological activity

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Dehydroepiandrosterone sulfate and Biological half-life

Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.

See Dehydroepiandrosterone sulfate and Blood–brain barrier

Brain-derived neurotrophic factor

Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein found in the and the periphery.

See Dehydroepiandrosterone sulfate and Brain-derived neurotrophic factor

Cause (medicine)

Cause, also known as etiology and aetiology, is the reason or origination of something.

See Dehydroepiandrosterone sulfate and Cause (medicine)

Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

See Dehydroepiandrosterone sulfate and Central nervous system

Cervical dilation

Cervical dilation (or cervical dilatation) is the opening of the cervix, the entrance to the uterus, during childbirth, miscarriage, induced abortion, or gynecological surgery.

See Dehydroepiandrosterone sulfate and Cervical dilation

Cervical effacement

Cervical effacement or cervical ripening refers to the thinning and shortening of the cervix.

See Dehydroepiandrosterone sulfate and Cervical effacement

Childbirth

Childbirth, also known as labour, parturition and delivery, is the completion of pregnancy where one or more babies exits the internal environment of the mother via vaginal delivery or caesarean section.

See Dehydroepiandrosterone sulfate and Childbirth

Cholesterol

Cholesterol is the principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Dehydroepiandrosterone sulfate and Cholesterol are Neurosteroids.

See Dehydroepiandrosterone sulfate and Cholesterol

Cholesterol side-chain cleavage enzyme

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage.

See Dehydroepiandrosterone sulfate and Cholesterol side-chain cleavage enzyme

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is a genetic disorder characterized by impaired production of cortisol in the adrenal glands.

See Dehydroepiandrosterone sulfate and Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Cortisol

Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.

See Dehydroepiandrosterone sulfate and Cortisol

Cushing's syndrome

Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol.

See Dehydroepiandrosterone sulfate and Cushing's syndrome

CYP17A1

Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.

See Dehydroepiandrosterone sulfate and CYP17A1

Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone precursor. Dehydroepiandrosterone sulfate and Dehydroepiandrosterone are Anabolic–androgenic steroids, androstanes, GABAA receptor negative allosteric modulators, NMDA receptor agonists, Neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone sulfate and Dehydroepiandrosterone

Depot injection

A depot injection is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.

See Dehydroepiandrosterone sulfate and Depot injection

Dihydrotestosterone

Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition. Dehydroepiandrosterone sulfate and Dihydrotestosterone are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone sulfate and Dihydrotestosterone

EMedicine

eMedicine is an online clinical medical knowledge base founded in 1996 by doctors Scott Plantz and Jonathan Adler, and computer engineer Jeffrey Berezin.

See Dehydroepiandrosterone sulfate and EMedicine

Endocrine Society

The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions.

See Dehydroepiandrosterone sulfate and Endocrine Society

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See Dehydroepiandrosterone sulfate and Endogeny (biology)

Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

See Dehydroepiandrosterone sulfate and Enzyme

Ester

In chemistry, an ester is a functional group derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group of that acid is replaced by an organyl group.

See Dehydroepiandrosterone sulfate and Ester

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

See Dehydroepiandrosterone sulfate and Estradiol

Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics.

See Dehydroepiandrosterone sulfate and Estrogen

Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone.

See Dehydroepiandrosterone sulfate and Estrone

Excretion

Excretion is elimination of metabolic waste, which is an essential process in all organisms.

See Dehydroepiandrosterone sulfate and Excretion

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Dehydroepiandrosterone sulfate and GABAA receptor

Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

See Dehydroepiandrosterone sulfate and Glucocorticoid

Glycine receptor

The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine.

See Dehydroepiandrosterone sulfate and Glycine receptor

Gonad

A gonad, sex gland, or reproductive gland is a mixed gland that produces the gametes and sex hormones of an organism.

See Dehydroepiandrosterone sulfate and Gonad

Hirsutism

Hirsutism is excessive body hair on parts of the body where hair is normally absent or minimal.

See Dehydroepiandrosterone sulfate and Hirsutism

Hormone

A hormone (from the Greek participle ὁρμῶν, "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physiology and behavior.

See Dehydroepiandrosterone sulfate and Hormone

Human serum albumin

Human serum albumin is the serum albumin found in human blood.

See Dehydroepiandrosterone sulfate and Human serum albumin

Hypopituitarism

Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain.

See Dehydroepiandrosterone sulfate and Hypopituitarism

Idiopathic disease

An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin.

See Dehydroepiandrosterone sulfate and Idiopathic disease

Japan

Japan is an island country in East Asia, located in the Pacific Ocean off the northeast coast of the Asian mainland.

See Dehydroepiandrosterone sulfate and Japan

Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

See Dehydroepiandrosterone sulfate and Kidney

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

See Dehydroepiandrosterone sulfate and Ligand (biochemistry)

Low-affinity nerve growth factor receptor

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor.

See Dehydroepiandrosterone sulfate and Low-affinity nerve growth factor receptor

Medication

A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

See Dehydroepiandrosterone sulfate and Medication

Menopause

Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of reproduction.

See Dehydroepiandrosterone sulfate and Menopause

Metabolic intermediate

Metabolic intermediates are molecules that are the precursors or metabolites of biologically significant molecules.

See Dehydroepiandrosterone sulfate and Metabolic intermediate

Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

See Dehydroepiandrosterone sulfate and Metabolism

Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

See Dehydroepiandrosterone sulfate and Metabolite

Microgram

In the metric system, a microgram or microgramme is a unit of mass equal to one millionth of a gram.

See Dehydroepiandrosterone sulfate and Microgram

Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

See Dehydroepiandrosterone sulfate and Natural product

Nerve growth factor

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.

See Dehydroepiandrosterone sulfate and Nerve growth factor

Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Dehydroepiandrosterone sulfate and Neurosteroid are Neurosteroids.

See Dehydroepiandrosterone sulfate and Neurosteroid

Neurotrophin

Neurotrophins are a family of proteins that induce the survival, development, and function of neurons.

See Dehydroepiandrosterone sulfate and Neurotrophin

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.

See Dehydroepiandrosterone sulfate and NMDA receptor

Ovary

The ovary is a gonad in the female reproductive system that produces ova.

See Dehydroepiandrosterone sulfate and Ovary

P2X purinoreceptor

The P2X receptors, also ATP-gated P2X receptor cation channel family, is a protein family that consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP).

See Dehydroepiandrosterone sulfate and P2X purinoreceptor

Polycystic ovary syndrome

Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age.

See Dehydroepiandrosterone sulfate and Polycystic ovary syndrome

Prasterone sulfate

Prasterone sulfate (brand names Astenile, Mylis, Teloin, others), also known as dehydroepiandrosterone sulfate (DHEA-S), is a naturally occurring androstane steroid which is marketed and used in Japan and other countries as a labor inducer in the treatment of insufficient cervical ripening and dilation during childbirth. Dehydroepiandrosterone sulfate and Prasterone sulfate are Anabolic–androgenic steroids, androgen esters, androstanes, GABAA receptor negative allosteric modulators, glycine receptor antagonists, NMDA receptor agonists, Neurosteroids, pregnane X receptor agonists, sigma agonists and sulfate esters.

See Dehydroepiandrosterone sulfate and Prasterone sulfate

Pregnenolone

Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. Dehydroepiandrosterone sulfate and Pregnenolone are Neurosteroids, pregnane X receptor agonists and sigma agonists.

See Dehydroepiandrosterone sulfate and Pregnenolone

Prohormone

A prohormone is a committed precursor of a hormone consisting of peptide hormones synthesized together that has a minimal hormonal effect by itself because of its expression-suppressing structure, often created by protein folding and binding additional peptide chains to certain ends, that makes hormone receptor binding sites located on its peptide hormone chain segments inaccessible.

See Dehydroepiandrosterone sulfate and Prohormone

Prostate cancer

Prostate cancer is the uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder.

See Dehydroepiandrosterone sulfate and Prostate cancer

Reference range

In medicine and health-related fields, a reference range or reference interval is the range or the interval of values that is deemed normal for a physiological measurement in healthy persons (for example, the amount of creatinine in the blood, or the partial pressure of oxygen).

See Dehydroepiandrosterone sulfate and Reference range

Sex hormone-binding globulin

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to androgens and estrogens.

See Dehydroepiandrosterone sulfate and Sex hormone-binding globulin

Sigma-1 receptor

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.

See Dehydroepiandrosterone sulfate and Sigma-1 receptor

Sodium salts

Sodium salts are salts composed of a sodium cation and the conjugate base anion of some inorganic or organic acids.

See Dehydroepiandrosterone sulfate and Sodium salts

Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

See Dehydroepiandrosterone sulfate and Steroid

Steroid hormone receptor

Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.

See Dehydroepiandrosterone sulfate and Steroid hormone receptor

Steroid sulfatase

Steroid sulfatase (STS), or steryl-sulfatase (EC 3.1.6.2), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids.

See Dehydroepiandrosterone sulfate and Steroid sulfatase

Sulfate

The sulfate or sulphate ion is a polyatomic anion with the empirical formula.

See Dehydroepiandrosterone sulfate and Sulfate

Sulfation

Sulfation is the chemical reaction that entails the addition of SO3 group.

See Dehydroepiandrosterone sulfate and Sulfation

Sulfotransferase

In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine.

See Dehydroepiandrosterone sulfate and Sulfotransferase

SULT1E1

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.

See Dehydroepiandrosterone sulfate and SULT1E1

Tanner scale

The Tanner scale (also known as the Tanner stages or sexual maturity rating (SMR)) is a scale of physical development as children transition into adolescence and then adulthood.

See Dehydroepiandrosterone sulfate and Tanner scale

Testosterone

Testosterone is the primary male sex hormone and androgen in males. Dehydroepiandrosterone sulfate and Testosterone are Anabolic–androgenic steroids and androstanes.

See Dehydroepiandrosterone sulfate and Testosterone

Transient receptor potential channel

Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types.

See Dehydroepiandrosterone sulfate and Transient receptor potential channel

Tropomyosin receptor kinase A

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

See Dehydroepiandrosterone sulfate and Tropomyosin receptor kinase A

TRPC5

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.

See Dehydroepiandrosterone sulfate and TRPC5

TRPV1

The transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene.

See Dehydroepiandrosterone sulfate and TRPV1

Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

See Dehydroepiandrosterone sulfate and Urine

Zona reticularis

The zona reticularis (sometimes, reticulate zone) is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla.

See Dehydroepiandrosterone sulfate and Zona reticularis

17α-Hydroxypregnenolone

17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. Dehydroepiandrosterone sulfate and 17α-Hydroxypregnenolone are pregnane X receptor agonists.

See Dehydroepiandrosterone sulfate and 17α-Hydroxypregnenolone

See also

NMDA receptor agonists

Pregnane X receptor agonists

References

[1] https://en.wikipedia.org/wiki/Dehydroepiandrosterone_sulfate

Also known as DHEA sulfate, DHEA-S, DHEAS, Dehydroepiandrosterone sulphate.

, Ligand (biochemistry), Low-affinity nerve growth factor receptor, Medication, Menopause, Metabolic intermediate, Metabolism, Metabolite, Microgram, Natural product, Nerve growth factor, Neurosteroid, Neurotrophin, NMDA receptor, Ovary, P2X purinoreceptor, Polycystic ovary syndrome, Prasterone sulfate, Pregnenolone, Prohormone, Prostate cancer, Reference range, Sex hormone-binding globulin, Sigma-1 receptor, Sodium salts, Steroid, Steroid hormone receptor, Steroid sulfatase, Sulfate, Sulfation, Sulfotransferase, SULT1E1, Tanner scale, Testosterone, Transient receptor potential channel, Tropomyosin receptor kinase A, TRPC5, TRPV1, Urine, Zona reticularis, 17α-Hydroxypregnenolone.