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Dihydroartemisinin

Index Dihydroartemisinin

Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria. [1]

28 relations: Aldehyde, Apicomplexa, Artemether, Artemether/lumefantrine, Artemisinin, Artesunate, Bile, Borohydride, Combination drug, Diisobutylaluminium hydride, Epoxide, Excipient, Gary H. Posner, Heme, Hemozoin, Hypervalent molecule, Lactol, Lithium borohydride, Liver, Malaria, Mechanism of action, Oxidative stress, Piperaquine, Plasmodium falciparum, Radical (chemistry), Red blood cell, Sodium borohydride, Tu Youyou.

Aldehyde

An aldehyde or alkanal is an organic compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain.

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Apicomplexa

The Apicomplexa (also called Apicomplexia) are a large phylum of parasitic alveolates.

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Artemether

Artemether is a medication used for the treatment of malaria.

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Artemether/lumefantrine

Artemether/lumefantrine, sold under the trade name Coartem among others, is a combination of the two medications artemether and lumefantrine.

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Artemisinin

Artemisinin and its semi-synthetic derivatives are a group of drugs used against Plasmodium falciparum malaria.

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Artesunate

Artesunate (AS) is a medication used to treat malaria.

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Bile

Bile or gall is a dark green to yellowish brown fluid, produced by the liver of most vertebrates, that aids the digestion of lipids in the small intestine.

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Borohydride

Borohydride refers to the anion BH4− and its salts.

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Combination drug

A combination drug is a fixed-dose combination (FDC) that includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in fixed doses.

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Diisobutylaluminium hydride

Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2).

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Epoxide

An epoxide is a cyclic ether with a three-atom ring.

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Excipient

An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts (thus often referred to as "bulking agents", "fillers", or "diluents"), or to confer a therapeutic enhancement on the active ingredient in the final dosage form, such as facilitating drug absorption, reducing viscosity, or enhancing solubility.

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Gary H. Posner

Gary H. Posner (2 June 1943 - 26 February 2018) was Scowe Professor of Chemistry at Johns Hopkins University in Baltimore, Maryland.

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Heme

Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.

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Hemozoin

Haemozoin is a disposal product formed from the digestion of blood by some blood-feeding parasites.

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Hypervalent molecule

A hypervalent molecule (the phenomenon is sometimes colloquially known as expanded octet) is a molecule that contains one or more main group elements apparently bearing more than eight electrons in their valence shells.

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Lactol

In organic chemistry, a lactol is the cyclic equivalent of a hemiacetal or a hemiketal.

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Lithium borohydride

Lithium borohydride (LiBH4) is a tetrahydroborate and known in organic synthesis as a reducing agent for esters.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Malaria

Malaria is a mosquito-borne infectious disease affecting humans and other animals caused by parasitic protozoans (a group of single-celled microorganisms) belonging to the Plasmodium type.

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Mechanism of action

In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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Piperaquine

Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria.

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Plasmodium falciparum

Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that cause malaria in humans.

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Radical (chemistry)

In chemistry, a radical (more precisely, a free radical) is an atom, molecule, or ion that has an unpaired valence electron.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Sodium borohydride

Sodium borohydride, also known as sodium tetrahydridoborate and sodium tetrahydroborate, is an inorganic compound with the formula NaBH4.

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Tu Youyou

Tu Youyou (born 30 December 1930) is a Chinese pharmaceutical chemist and educator.

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Redirects here:

ATC code P01BE05, Artenimol, C15H24O5, Dihydroartemesinin, Dihydroartemisinine, Dihydroartemsinin.

References

[1] https://en.wikipedia.org/wiki/Dihydroartemisinin

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