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Dinaciclib

Index Dinaciclib

Dinaciclib (SCH-727965) is an experimental drug that inhibits cyclin-dependent kinases (CDKs). [1]

13 relations: Apoptosis, Bromodomain, Chronic lymphocytic leukemia, Cyclin-dependent kinase, Cyclin-dependent kinase 1, Cyclin-dependent kinase 5, Cytokine, Melanoma, Merck & Co., Orphan drug, Pancreatic cancer, Unfolded protein response, Xenotransplantation.

Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Bromodomain

A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones.

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Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).

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Cyclin-dependent kinase

Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle.

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Cyclin-dependent kinase 1

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation.

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Cyclin-dependent kinase 5

Cell division protein kinase 5 is an enzyme that in humans is encoded by the CDK5 gene.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Melanoma

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Merck & Co.

Merck & Company, Inc., d.b.a. Merck Sharp & Dohme (MSD) outside the United States and Canada, is an American pharmaceutical company and one of the largest pharmaceutical companies in the world.

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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.

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Pancreatic cancer

Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.

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Unfolded protein response

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress.

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Xenotransplantation

Xenotransplantation (xenos- from the Greek meaning "foreign"), is the transplantation of living cells, tissues or organs from one species to another.

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References

[1] https://en.wikipedia.org/wiki/Dinaciclib

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