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Dopamine agonist

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A dopamine receptor agonist is a compound that activates dopamine receptors. [1]

103 relations: ACS Chemical Neuroscience, Adrenergic agonist, Agonist, Amphetamine, Anorexia (symptom), Antipsychotic, Apomorphine, Aripiprazole, Arrestin, Attention deficit hyperactivity disorder, Binge eating disorder, British Journal of Pharmacology, Bromocriptine, Bupropion, Cabergoline, Cathinone, Cell signaling, Ciladopa, Cocaine, Dexmethylphenidate, Dextroamphetamine, Dihydrexidine, Dinapsoline, Dizziness, Dopamine antagonist, Dopamine receptor, Dopamine receptor D1, Dopamine receptor D3, Dopamine releasing agent, Dopamine reuptake inhibitor, Dopaminergic, Doxanthrine, Drug, Drug class, Drugs & Aging, Dysphoria, EC50, Epicriptine, Euphoria, Fenoldopam, Functional selectivity, G protein, GABA receptor agonist, Hallucination, Histamine agonist, Human Reproduction (journal), In vitro fertilisation, Indirect agonist, Insomnia, Intrinsic activity, ..., Κ-opioid receptor, Lightheadedness, Lisdexamfetamine, Lisuride, Major depressive disorder, Methamphetamine, Methylphenidate, Narcolepsy, Nausea, Nicotine, NMDA receptor antagonist, Obesity, Orgasm, Orthostatic hypotension, Ovarian hyperstimulation syndrome, Parasympathomimetic drug, Parkinson's disease, Pergolide, Pericardial effusion, Perspiration, Phencyclidine, Phenethylamine, Piribedil, Post-acute-withdrawal syndrome, Pramipexole, Prolactinoma, Propylnorapomorphine, Psychosis, Quinagolide, Quinpirole, Raynaud syndrome, Restless legs syndrome, Ropinirole, Rotigotine, Roxindole, Salvia divinorum, Salvinorin A, Selective serotonin reuptake inhibitor, Serotonin receptor agonist, Sexual dysfunction, Smoking cessation, Somnolence, Stimulant, Sumanirole, Sympathomimetic drug, Syncope (medicine), Trace amine, Transcription (biology), Tyramine, United States National Library of Medicine, Vomiting, Weight loss, Withdrawal syndrome. Expand index (53 more) »

ACS Chemical Neuroscience

ACS Chemical Neuroscience is a peer-reviewed scientific journal published by the American Chemical Society.

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Adrenergic agonist

An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors.

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An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

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Anorexia (symptom)

Anorexia (from Ancient Greek ανορεξία: 'ἀν-' "without" + 'όρεξις', spelled 'órexis' meaning "appetite") is the decreased sensation of appetite.

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Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.

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Apomorphine (brand names Apokyn, Ixense, Spontane, Uprima) is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors.

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Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.

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Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors.

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Attention deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.

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Binge eating disorder

Binge eating disorder (BED) is an eating disorder characterized by frequent and recurrent binge eating episodes with associated negative psychological and social problems, but without subsequent purging episodes (e.g. vomiting).

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British Journal of Pharmacology

The British Journal of Pharmacology is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology.

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Bromocriptine (originally marketed as Parlodel, subsequently under many names) is an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

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Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used as an antidepressant and smoking cessation aid.

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Cabergoline (brand names Dostinex and others), an ergot derivative, is a potent dopamine receptor agonist on D2 receptors.

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Cathinone (also known as benzoylethanamine, or β-keto-amphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines.

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Ciladopa (AY-27,110) is a dopamine agonist with a similar chemical structure to dopamine.

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Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.

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Dexmethylphenidate, sold under the trade names Focalin among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

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Dextroamphetamine is a potent central nervous system (CNS) stimulant and amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

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Dihydrexidine (DAR-0100) is a moderately selective full agonist at the dopamine D1 and D5 receptors.

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Dinapsoline is a drug developed for the treatment of Parkinson's disease, that acts as a selective full agonist at the dopamine D1 receptor.

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Dizziness is an impairment in spatial perception and stability.

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Dopamine antagonist

A dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism.

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Dopamine receptor

Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).

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Dopamine receptor D1

Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.

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Dopamine receptor D3

Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.

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Dopamine releasing agent

A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain.

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Dopamine reuptake inhibitor

A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT).

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Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.

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Doxanthrine is a synthetic compound which is a potent and selective full agonist for the dopamine D1 receptor.

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A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.

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Drug class

A drug class is a set of medications that have similar chemical structures, the same mechanism of action (i.e., bind to the same biological target), a related mode of action, and/or are used to treat the same disease.

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Drugs & Aging

Drugs & Aging is a monthly peer-reviewed medical journal published by Springer Science + Business Media under their Adis International imprint.

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Dysphoria (from δύσφορος (dysphoros), δυσ-, difficult, and φέρειν, to bear) is a profound state of unease or dissatisfaction.

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Half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.

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Epicriptine or beta-dihydroergocryptine is a dopamine agonist of the ergoline class.

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Euphoria is an affective state in which a person experiences pleasure or excitement and intense feelings of well-being and happiness.

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Fenoldopam mesylate (Corlopam) is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.

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Functional selectivity

Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.

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G protein

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

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GABA receptor agonist

A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects.

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A hallucination is a perception in the absence of external stimulus that has qualities of real perception.

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Histamine agonist

A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.

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Human Reproduction (journal)

Human Reproduction is a peer-reviewed scientific journal covering all aspects of human reproduction, including reproductive physiology and pathology, endocrinology, andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, pregnancy, genetics, preimplantation genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics, and social issues.

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In vitro fertilisation

In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm outside the body, in vitro ("in glass").

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Indirect agonist

In pharmacology, an indirect agonist or indirect-acting agonist is a substance that enhances the release or action of an endogenous neurotransmitter but has no specific agonist activity at the neurotransmitter receptor itself.

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Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

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Intrinsic activity

Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.

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Κ-opioid receptor

The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.

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Lightheadedness is a common and typically unpleasant sensation of dizziness and/or a feeling that one may faint.

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Lisdexamfetamine (contracted from L-'''lys'''ine-'''dex'''tro'''amphetamine''') is a substituted amphetamine and an inactive prodrug of the central nervous system (CNS) stimulant dextroamphetamine that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and binge eating disorder.

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Lisuride, sold under the brand names Dopergin, Proclacam, and Revanil, is an antiparkinson agent of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Methamphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity.

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Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

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Narcolepsy is a long-term neurological disorder that involves a decreased ability to regulate sleep-wake cycles.

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Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.

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Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants.

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NMDA receptor antagonist

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor (NMDAR).

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Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Orgasm (from Greek ὀργασμός orgasmos "excitement, swelling"; also sexual climax) is the sudden discharge of accumulated sexual excitement during the sexual response cycle, resulting in rhythmic muscular contractions in the pelvic region characterized by sexual pleasure.

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Orthostatic hypotension

Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.

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Ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome (OHSS) is a medical condition that can occur in some women who take fertility medication to stimulate egg growth, and in other women in very rare cases.

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Parasympathomimetic drug

A parasympathomimetic drug, sometimes called a cholinomimetic drug, is a substance that stimulates the parasympathetic nervous system (PSNS).

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Pergolide (trade names Permax, Prascend) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease (PD).

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Pericardial effusion

Pericardial effusion ("fluid around the heart") is an abnormal accumulation of fluid in the pericardial cavity.

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Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals.

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Phencyclidine (PCP), also known as angel dust among other names, is a drug used for its mind altering effects.

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Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.

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Piribedil (trade names Pronoran, Trivastal Retard, Trastal, Trivastan, Clarium and others) is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist.

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Post-acute-withdrawal syndrome

Post-acute-withdrawal syndrome (PAWS) describe a set of persistent impairments that occur after withdrawal from alcohol, opiates, benzodiazepines, antidepressants and other substances.

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Pramipexole (Mirapex, Mirapexin, Sifrol) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

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A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called prolactin.

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N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine.

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Psychosis is an abnormal condition of the mind that results in difficulties telling what is real and what is not.

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Quinagolide (INN, BAN; brand name Norprolac) is a selective D2 receptor agonist that is used to reduce elevated levels of prolactin (hyperprolactinemia).

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Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist.

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Raynaud syndrome

Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which spasm of arteries cause episodes of reduced blood flow.

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Restless legs syndrome

Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one's legs.

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Ropinirole (INN; trade names Requip, Repreve, Ronirol, Adartrel) is a dopamine agonist of the non-ergoline class of medications.

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Rotigotine (Neupro) is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS).

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Roxindole (EMD-49,980) is a dopaminergic and serotonergic drug which was originally developed for the treatment of schizophrenia.

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Salvia divinorum

Salvia divinorum (also known as sage of the diviners, ska maría pastora, seer's sage, yerba de la pastora or simply salvia) is a plant species with transient psychoactive properties when its leaves are consumed by chewing, smoking or as a tea.

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Salvinorin A

Salvinorin A is the main active psychotropic molecule in Salvia divinorum, a Mexican plant which has a long history of use as an entheogen by indigenous Mazatec shamans.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Serotonin receptor agonist

A serotonin receptor agonist is an agonist of one or more serotonin receptors.

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Sexual dysfunction

Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.

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Smoking cessation

Smoking cessation (also known as quitting smoking or simply quitting) is the process of discontinuing tobacco smoking.

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Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

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Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.

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Sumanirole (PNU-95,666) is a highly selective D2 receptor full agonist, the first of its kind to be discovered.

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Sympathomimetic drug

Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system.

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Syncope (medicine)

Syncope, also known as fainting, is a loss of consciousness and muscle strength characterized by a fast onset, short duration, and spontaneous recovery.

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Trace amine

Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists – and hence, monoaminergic neuromodulators – that are structurally and metabolically related to classical monoamine neurotransmitters.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Tyramine (also spelled tyramin), also known by several other names is a naturally occurring trace amine derived from the amino acid tyrosine.

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United States National Library of Medicine

The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.

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Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.

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Weight loss

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue.

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Withdrawal syndrome

A withdrawal syndrome (also called a discontinuation syndrome) is a set of symptoms occurring in discontinuation or dosage reduction of some types of medications and recreational drugs.

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Dopamine agonists, Dopamine partial agonists, Dopamine receptor agonist, Dopamine receptor agonists, Dopaminergic agonists.


[1] https://en.wikipedia.org/wiki/Dopamine_agonist

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