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Drug of last resort

Index Drug of last resort

A drug of last resort (DoLR) is a pharmaceutical drug that is tried after all other drug options have failed to produce an adequate response in the patient. [1]

73 relations: Acinetobacter baumannii, Acute decompensated heart failure, Adverse drug reaction, Agranulocytosis, Alcohol withdrawal syndrome, Amikacin, Amphotericin B, Antibiotic, Anticonvulsant, Antimicrobial resistance, Antineoplastic resistance, Antiviral drug, Aplastic anemia, Benzodiazepine, Carbapenem, Ceftaroline fosamil, Ceftobiprole, Centers for Disease Control and Prevention, Cephalosporin, Chemotherapy, Chloramphenicol, Cisapride, Clomethiazole, Clozapine, Colistin, Conjunctivitis, Dexamethasone, Dose–response relationship, Doxycycline, Drug interaction, Drug resistance, Epilepsy, Epileptic seizure, Erythema nodosum, Felbamate, Food and Drug Administration, Gray baby syndrome, Heart failure, Hepatotoxicity, Hypertensive crisis, Imipenem/cilastatin, Intensive care medicine, Intravenous therapy, Levosimendan, Linezolid, Liver failure, Medication, Meningitis, Methicillin-resistant Staphylococcus aureus, Minoxidil, ..., Monoamine oxidase inhibitor, Multiple drug resistance, Multiple myeloma, Myocarditis, Parkinson's disease, Penicillin, Phocomelia, Polymyxin, Rocky Mountain spotted fever, Salvage therapy, Selective serotonin reuptake inhibitor, Sepsis, Septic shock, Serotonin syndrome, Serotonin–norepinephrine reuptake inhibitor, Thalidomide, Tigecycline, Tolcapone, Vancomycin, Vancomycin-resistant Enterococcus, Vancomycin-resistant Staphylococcus aureus, Vigabatrin, World Health Organization. Expand index (23 more) »

Acinetobacter baumannii

Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium.

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Acute decompensated heart failure

Acute decompensated heart failure (ADHF) is a sudden worsening of the signs and symptoms of heart failure, which typically includes difficulty breathing (dyspnea), leg or feet swelling, and fatigue.

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Adverse drug reaction

An adverse drug reaction (ADR) is an injury caused by taking a medication.

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Agranulocytosis

Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils causing a neutropenia in the circulating blood.

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Alcohol withdrawal syndrome

Alcohol withdrawal syndrome is a set of symptoms that can occur following a reduction in alcohol use after a period of excessive use.

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Amikacin

Amikacin is an antibiotic used for a number of bacterial infections.

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Amphotericin B

Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis.

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Antibiotic

An antibiotic (from ancient Greek αντιβιοτικά, antibiotiká), also called an antibacterial, is a type of antimicrobial drug used in the treatment and prevention of bacterial infections.

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Anticonvulsant

Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.

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Antimicrobial resistance

Antimicrobial resistance (AMR or AR) is the ability of a microbe to resist the effects of medication that once could successfully treat the microbe.

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Antineoplastic resistance

Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the multiple drug resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies.

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Antiviral drug

Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones.

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Aplastic anemia

Aplastic anaemia is a rare disease in which the bone marrow and the hematopoietic stem cells that reside there are damaged.

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Benzodiazepine

Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

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Carbapenem

Carbapenems are a class of highly effective antibiotic agents commonly used for the treatment of severe or high-risk bacterial infections.

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Ceftaroline fosamil

Ceftaroline fosamil (INN), brand name Teflaro in the US and Zinforo in Europe, is a fifth-generation cephalosporin antibiotic.

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Ceftobiprole

Ceftobiprole (Zevtera/Mabelio) is a new 5th-generation cephalosporine for the treatment of hospital-acquired pneumonia (HAP, excluding ventilator-associated pneumonia, VAP) and community-acquired pneumonia (CAP).

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Centers for Disease Control and Prevention

The Centers for Disease Control and Prevention (CDC) is the leading national public health institute of the United States.

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Cephalosporin

The cephalosporins (sg.) are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Chloramphenicol

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.

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Cisapride

Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract.

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Clomethiazole

Clomethiazole (also called chlormethiazole) is a sedative and hypnotic originally developed by Hoffmann-La Roche in the 1930s.

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Clozapine

Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.

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Colistin

Colistin, also known as polymyxin E, is an antibiotic produced by certain strains of the bacteria Paenibacillus polymyxa.

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Conjunctivitis

Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid.

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Dexamethasone

Dexamethasone is a type of corticosteroid medication.

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Dose–response relationship

The dose–response relationship, or exposure–response relationship, describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time, or to a food.

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Doxycycline

Doxycycline is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa.

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Drug interaction

A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together.

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Drug resistance

Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a disease or condition.

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Epilepsy

Epilepsy is a group of neurological disorders characterized by epileptic seizures.

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Epileptic seizure

An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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Erythema nodosum

Erythema nodosum (EN), also known as subacute migratory panniculitis of Vilanova and Piñol, is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins.

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Felbamate

Felbamate (marketed under the brand name Felbatol by MedPointe) is an anticonvulsant used in the treatment of epilepsy.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Gray baby syndrome

Gray baby syndrome (also termed Gray or Grey syndrome) is a rare but serious side effect that occurs in newborn infants (especially premature babies) following the accumulation of antibiotic chloramphenicol.

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Heart failure

Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

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Hypertensive crisis

Severely elevated blood pressure (equal to or greater than a systolic 180 or diastolic of 110—sometimes termed malignant or accelerated hypertension) is referred to as a hypertensive crisis, as blood pressure at this level confers a high risk of complications.

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Imipenem/cilastatin

Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections.

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Intensive care medicine

Intensive care medicine, or critical care medicine, is a branch of medicine concerned with the diagnosis and management of life-threatening conditions that may require sophisticated life support and monitoring.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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Levosimendan

Levosimendan (INN) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.

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Linezolid

Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics.

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Liver failure

Liver failure or hepatic insufficiency is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology.

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Medication

A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Meningitis

Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.

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Methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) refers to a group of gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus.

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Minoxidil

No description.

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Monoamine oxidase inhibitor

Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).

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Multiple drug resistance

Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to multiple antimicrobial drugs.

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Multiple myeloma

Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.

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Myocarditis

Myocarditis, also known as inflammatory cardiomyopathy, is inflammation of the heart muscle.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Penicillin

Penicillin (PCN or pen) is a group of antibiotics which include penicillin G (intravenous use), penicillin V (use by mouth), procaine penicillin, and benzathine penicillin (intramuscular use).

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Phocomelia

Phocomelia is a condition that involves malformations of the arms and legs.

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Polymyxin

Polymyxins are antibiotics.

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Rocky Mountain spotted fever

Rocky Mountain spotted fever (RMSF), also known as blue disease, is the most lethal and most frequently reported rickettsial illness in the United States.

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Salvage therapy

Salvage therapy, also known as rescue therapy, is a form of therapy given after an ailment does not respond to standard therapy.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

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Septic shock

Septic shock is a serious medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

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Serotonin syndrome

Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.

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Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.

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Thalidomide

Thalidomide, sold under the brand name Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs.

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Tigecycline

Tigecycline is an antibiotic used to treat a number of bacterial infections.

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Tolcapone

Tolcapone (brand name Tasmar) is a drug used to treat Parkinson's disease (PD).

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Vancomycin

Vancomycin is an antibiotic used to treat a number of bacterial infections.

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Vancomycin-resistant Enterococcus

Vancomycin-resistant Enterococcus, or vancomycin-resistant enterococci (VRE), are bacterial strains of the genus Enterococcus that are resistant to the antibiotic vancomycin.

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Vancomycin-resistant Staphylococcus aureus

Vancomycin-resistant Staphylococcus aureus are strains of Staphylococcus aureus that have become resistant to the glycopeptide antibiotic vancomycin.

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Vigabatrin

Vigabatrin, brand name Sabril, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of the enzyme GABA transaminase (GABA-T).

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World Health Organization

The World Health Organization (WHO; French: Organisation mondiale de la santé) is a specialized agency of the United Nations that is concerned with international public health.

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Redirects here:

Antibiotic of last resort, Antibiotics of last resort, Last-resort antibiotic.

References

[1] https://en.wikipedia.org/wiki/Drug_of_last_resort

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