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E-4031

Index E-4031

E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type. [1]

15 relations: C-terminus, Cardiac action potential, Chemoreceptor, Clinical trial, Guinea pig, Heart arrhythmia, HERG, Long QT syndrome, Myocyte, Pituitary adenoma, Potassium channel, Proceedings of the National Academy of Sciences of the United States of America, QT interval, Toxin, Voltage-gated potassium channel.

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cardiac action potential

The cardiac action potential is a brief change in voltage (membrane potential) across the cell membrane of heart cells.

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Chemoreceptor

A chemoreceptor, also known as chemosensor, is a specialized sensory receptor cell which transduces (responds to) a chemical substance (endogenous or induced) and generates a biological signal.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Guinea pig

The guinea pig or domestic guinea pig (Cavia porcellus), also known as cavy or domestic cavy, is a species of rodent belonging to the family Caviidae and the genus Cavia.

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Heart arrhythmia

Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.

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HERG

hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel.

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Long QT syndrome

Long QT syndrome (LQTS) is a condition which affects repolarization of the heart after a heartbeat.

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Myocyte

A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue.

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Pituitary adenoma

Pituitary adenomas are tumors that occur in the pituitary gland.

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Potassium channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America (PNAS) is the official scientific journal of the National Academy of Sciences, published since 1915.

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QT interval

In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.

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Toxin

A toxin (from toxikon) is a poisonous substance produced within living cells or organisms; synthetic toxicants created by artificial processes are thus excluded.

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Voltage-gated potassium channel

Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential.

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References

[1] https://en.wikipedia.org/wiki/E-4031

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