E-52862

E-52862, also known as sigma-1 receptor antagonist (S1A, S1RA), as well as MR-309, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki. ^[1]

9 relations: Binding selectivity, Esteve, Ligand (biochemistry), List of investigational analgesics, Neuropathic pain, Pain, Receptor antagonist, Sigma-1 receptor, Sigma-2 receptor.

Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Esteve

Esteve is a Spanish international pharmaceutical company headquartered in Barcelona.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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List of investigational analgesics

This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved.

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Neuropathic pain

Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system.

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Pain

Pain is a distressing feeling often caused by intense or damaging stimuli.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Sigma-1 receptor

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor.

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The sigma-2 receptor (σ2R) is a sigma receptor subtype that has been found highly expressed in malignant cancer cells, and is currently under investigation for its potential diagnostic and therapeutic uses.

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Redirects here:

S1RA.

References

[1] https://en.wikipedia.org/wiki/E-52862

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